Effects of vacuum sealing drainage on the treatment of cranial bone-exposed wounds in rabbits

Abstract

This study was designed to assess the efficacy of vacuum sealing drainage (VSD) on skull exposure wounds in rabbits and to investigate the underlying mechanism of the process. Full-thickness excisional circular wounds 2×2 cm with or without periosteum involvement were created in 88 New Zealand white rabbits (mean body weight: 3.0±0.65 kg). Animals were randomly divided into 4 groups: periosteum-intact wounds treated with traditional dressing (p+control), periosteum-intact wounds treated with VSD (p+VSD), periosteum-lacking wounds treated with traditional dressing (p–control) and periosteum-lacking wounds treated with VSD (p–VSD). The wounds treated with traditional dressing were covered with Vaseline gauze, while VSD treatment was accompanied with continuous –120 mmHg pressure. Finally, wound tissues were harvested for analysis of hydroxyproline content and histologic detection. VSD hastened the wound healing process significantly (P<0.05) compared to the corresponding control groups. VSD alleviated the inflammation reaction, accelerated re-epithelialization and facilitated the organization of collagen fibers into neat rows. During the wound healing process, the hydroxyproline content increased overtime [i.e., postoperative days (POD) 7, POD 10 and POD 15] in all four groups, and it peaked in the p+VSD group. VSD also promoted angiogenesis via increasing number and quality of collagen. We concluded that VSD can promote healing in bone-exposed wounds via increasing hydroxyproline content and vessel density, reducing inflammatory responses and generating ordered collagen arrangement.

The efficacy of artificial dermis combined with continuous vacuum sealing drainage in deep neck multiple spaces infection treatment

“…VSD promotes angiogenesis by increasing the quantity and quality of collagen. [ 19 ] Additionally, VSD can increase the expression of transforming growth factor β1 (TGF-β1), which will promote granulation tissue growth and contribute to wound healing. [ 20 ] The duration of antibiotic use in the VSD group was lower than in the traditional group.…”

A novel treatment approach for traumatic scalp defects with exposed calvaria denuded of pericranium by combined application of low‐temperature plasma and negative pressure wound therapy: A case series

“…NPWT has been shown to promote tissue granulation and decrease wound volume by debriding devitalized tissue, promoting blood flow and tissue perfusion, decreasing bacterial colonization, and removing excess serous fluid 1,5,12,13 . However, in my experience of this and previous cases, patients report pain and discomfort throughout the NPWT treatment period; two required opioid medications for pain control.…”

Vacuum sealing drainage combined with naso-intestinal and gastric decompression tubes for the treatment of esophagogastrostomy neck fistula

“…Some studies have shown that adding medication irrigation, such as ozonated water and recombinant human epidermal growth factor, could accelerate wound healing [ 18 , 19 ]. Animal experiments have shown that VSD can effectively promote wound healing by increasing the vessel density with hydroxyproline content, reducing the inflammatory responses and generating an ordered collagen arrangement [ 20 ]. Compared with traditional wound debridement and dressing changes, VSDs theoretically have the potential to reduce the frequency of dressing changes, shorten the healing time, and increase the success rate of wound healing.…”