Advances
in cardiovascular materials have brought us improved artificial
vessels with larger diameters for reducing adverse responses that
drive acute thrombosis and the associated complications. Nonetheless,
the challenge is still considerable when applying these materials
in small-diameter blood vessels. Here we report the biomimetic design
of an acellular small-diameter vascular graft with specifically lamellar
nanotopography on the luminal surface via a modified freeze-cast technique.
The experimental findings verify that the well-designed nanolamellar
structure is able to inhibit the adherence and activation of platelets,
induce oriented growth of endothelial cells, and eventually remodel
a neovessel to maintain long-term patency in vivo. Furthermore, the results of numerical simulations in physically
mimetic conditions reveal that the regularly lamellar nanopattern
can manipulate blood flow to reduce the flow disturbance compared
with random topography. Our current work not only creates a freeze-cast
small-diameter vascular graft that employs topographic architecture
to direct the vascular cell fates for revasculature but also rekindles
confidence in biophysical cues for modulating in situ tissue regeneration.
Complete skin reconstruction is a hierarchically physiological assembly involving epidermis, dermis, vasculature, innervation, hair follicles, and sweat glands. Despite various wound dressings having been developed for skin regeneration, few works refer to the complete skin regeneration, particularly lacking for vasculatures and hair follicles. Herein, an instructive wound dressing that integrates the antibacterial property of quaternized chitin and the mechanical strength and biological multifunction of silk fibroin through layer-by-layer electrostatic self-assembly is designed and reported. The resultant dressings exhibit a nanofibrous structure ranging from 471.5 ± 212.1 to 756.9 ± 241.8 nm, suitable flexibility with tensile strength up to 4.47 ± 0.29 MPa, and broad-spectrum antibacterial activity against Escherichia coli and Staphylococcus aureus. More interestingly, the current dressing system remarkably accelerates in vivo vascular reconstruction within 15 days, and the number of regenerated hair follicles reaches up to 22 ± 4 mm −2 , which is comparable to the normal tissue (27 ± 2 mm −2). Those crucial functions might originate from the combination between quaternized chitin and silk fibroin and the hierarchical structure of electrospun nanofiber. This work establishes an easy but effective pathway to design a multifunctional wound dressing for the complete skin regeneration.
Deep neck abscesses are dangerous. Artificial dermis combined with seal negative pressure drainage is a new technique for treating refractory wounds.
To compare the efficacy of vacuum sealing drainage (VSD) with that of traditional incision drainage approaches for treating deep neck multiple spaces infections.
This retrospective analysis includes patient data from our hospital collected from January 2010 to March 2020. A total of 20 cases were identified. Based on the treatment methods, the patients were divided into the VSD group and the traditional group. Inflammation indicators (white blood count, WBC), duration of antibiotic use, hospitalization time, doctors’ workload (frequency of dressing changes) and treatment cost were analyzed and compared between the two groups.
Of the 20 patients, 11 patients underwent treatment with VSD, while the other 9 underwent traditional treatment. All patients were cured after treatment. Compared with the traditional group, the VSD group had a slower decline in the inflammation index, shorter duration of antibiotic use, shorter hospital stay, and lower doctor workloads (
P
< .001). There was no significant difference in treatment cost between the two groups (
P
> .05).
VSD technology can markedly improve the therapeutic effect of deep neck multiple spaces infection. This treatment method can be used to rapidly control infections and is valuable in the clinic (
P
> .05).
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