Effect of salt intake and potassium supplementation on brachial-ankle pulse wave velocity in Chinese subjects: an interventional study

Abstract

Accumulating evidence has suggested that high salt and potassium might be associated with vascular function. The aim of this study was to investigate the effect of salt intake and potassium supplementation on brachial-ankle pulse wave velocity (PWV) in Chinese subjects. Forty-nine subjects (28-65 years of age) were selected from a rural community of northern China. All subjects were sequentially maintained on a low-salt diet for 7 days (3.0 g/day NaCl), a high-salt diet for an additional 7 days (18.0 g/day NaCl), and a high-salt diet with potassium supplementation for a final 7 days (18.0 g/day NaCl+4.5 g/day KCl). Brachial-ankle PWV was measured at baseline and on the last day of each intervention. Blood pressure levels were significantly increased from the low-salt to high-salt diet, and decreased from the high-salt diet to high-salt plus potassium supplementation. Baseline brachial-ankle PWV in salt-sensitive subjects was significantly higher than in salt-resistant subjects. There was no significant change in brachial-ankle PWV among the 3 intervention periods in salt-sensitive, salt-resistant, or total subjects. No significant correlations were found between brachial-ankle PWV and 24-h sodium and potassium excretions. Our study indicates that dietary salt intake and potassium supplementation, at least in the short term, had no significant effect on brachial-ankle PWV in Chinese subjects.

The Relationships of the Fractional Excretion of Uric Acid with Brachial-Ankle Pulse Wave Velocity and Ankle Brachial Index in Chinese Young Adults

“…BaPWV and ABI were measured using a volume-plethysmographic apparatus (BP-203RPEII; Nihon Colin, Tokyo, Japan) [16, 17]. Participants were in the supine position with cuffs, which were connected to a plethysmographic sensor and an oscillometric pressure sensor, wrapped around both the brachium and ankles.…”

Current Data on Dietary Sodium, Arterial Structure and Function in Humans: A Systematic Review

“…Thirty-one (31) studies examining arteriosclerosis were identified-of which, 14 were observational [15][16][17][18][19][20][27][28][29][30][31][32][33][34] and 17 were interventional [22,23,[35][36][37][38][39][40][41][42][43][44][45][46][47][48][49].…”

“…From the 17 interventional studies investigating the association between arteriosclerosis [22,23,[35][36][37][38][39][40][41][42][43][44][45][46][47][48][49], seven of them showed statistically significant changes in arterial stiffness biomarkers after Na intake intervention [35,37,38,[44][45][46]49]. On the contrary, 10 out of the 17 interventional studies found no changes in arterial stiffness biomarkers with various levels of Na intake during the intervention [22,23,36,[39][40][41][42][43]47,48] ( Table 2).…”

Plasma Renalase is Not Associated with Blood Pressure and Brachial-Ankle Pulse Wave Velocity in Chinese Adults With Normal Renal Function

“…BP was measured by three trained staff members using a standard mercury sphygmomanometer, as previously described [23,24]. In brief, the subjects were instructed to rest in a sitting position for more than 5 min, and their right brachial pressure was measured while they were in a sitting position.…”

“…baPWV Measurement baPWV was measured by standard method using tonometry as previously described [23]. Briefly, cuffs with a plethysmographic sensor that acquired waveform data and BP measurements were placed around the arms and ankles bilaterally (BP-203RPEII; Nihon Colin, Tokyo, Japan).…”