The Relationships of the Fractional Excretion of Uric Acid with Brachial-Ankle Pulse Wave Velocity and Ankle Brachial Index in Chinese Young Adults

Abstract

Background/Aims: Elevated serum uric acid (UA) was intimately correlated with vascular stiffness and abnormal ankle brachial index (ABI) in various populations. These correlations lost significance after adjustment for estimated glomerular filtration rate (eGFR), indicating that the association of UA and brachial-ankle pulse wave velocity (baPWV) or ABI might be driven by kidney function. UA is predominantly eliminated through the kidneys, and metabolic disorders can influence the clearance of UA. In this study, we aimed to explore the putative correlation between FEUA and baPWV or ABI to determine to what extent the associations with UA were affected by renal function. Methods: This cross-sectional study enrolled 2351 participants, who underwent general health screening in Hanzhong people’s hospital from March to June of 2017. BaPWV and ABI were measured using a volume-plethysmographic apparatus (BP-203RPEII; Nihon Colin, Tokyo, Japan). FEUA was divided into quartiles: Q1:FEUA≤3.07; Q2: 3.07<FEUA≤5.32; Q3: 5.32<FEUA≤9.19; and Q4: FEUA> 9.19. Results: Lower FEUA predicted a higher prevalence of high baPWV and low ABI (p for trend <0.001). The respective ORs for high baPWV from the first to the third quartiles of FEUA were 1.777(1.323, 2.387); 1.561(1.158, 2.104); and 1.680 (1.250, 2.259). The prevalence of low ABI was greatly elevated with the decrement of FEUA [ORs for the first to third FEUA quartiles were 6.977(2.062, 23.610); 5.123(1.475, 17.790); and 2.685(0.709, 10.171), respectively]. The association of FEUA and ABI was independent of related confounding factors. However, the association between FEUA and baPWV was greatly influenced by corresponding confounders, especially gender. The efficacy of FEUA in the prediction of low ABI was stronger than that of serum UA. However, serum UA was more powerful in the prediction of high baPWV. Conclusion: Kidney function exerted a profound influence on the relationship between UA and baPWV or ABI, revealing complex interactions among cardiovascular risk factors.

Effect of metabolically healthy obesity on the development of arterial stiffness: a prospective cohort study

“…The assessment of baPWV was analyzed by a volumeplethysmographic apparatus (BP-203RPEII; Nihon Colin, Tokyo, Japan). Detailed collection information has been reported previously [25,26]. Individuals were asked to maintain a supine position without a pillow.…”

Association of Uric Acid in Serum and Urine with Arterial Stiffness: Hanzhong Adolescent Hypertension Study

“…BaPWV ≥ 1400 cm/s is an independent variable for risk stratification by Framingham score and for discrimination of subjects with cardiovascular disease. Therefore, high baPWV was defined as baPWV ≥ 1,400 cm/s [ 30 , 36 ].…”

“…Markers of Arterial Stiffness. BaPWV was measured using a volume-plethysmographic device (BP-203RPEII, Nihon Colin, Japan) as previously reported [25,30,[35][36][37]. The average value of baPWV values on both sides was used for analysis.…”

“…BaPWV ≥ 1400 cm/s is an independent variable for risk stratification by Framingham score and for discrimination of subjects with cardiovascular disease. Therefore, high baPWV was defined as baPWV ≥ 1,400 cm/s [30,36]. The CIMT, defined as the distance the distance from the intima-luminal interface to the media-adventitial interface, was measured as described elsewhere [25,38].…”

Predictors for progressions of brachial–ankle pulse wave velocity and carotid intima–media thickness over a 12-year follow-up

“…Brachial–ankle pulse wave velocity (baPWV) measurement is a validated method for quantifying arterial stiffness [9]. baPWV is easy and convenient to perform and can be widely used in large-scale populations and clinical settings [9–11]. Prior studies have suggested that the principal determinants of PWV progression are a number of cardiovascular risk factors, such as dyslipidemia, obesity, diabetes, elevated blood pressure (BP), higher heart rate (HR) and chronic kidney disease [12–16].…”