Association of Uric Acid in Serum and Urine with Arterial Stiffness: Hanzhong Adolescent Hypertension Study

Wang, Yang; Zhang, Xiaoyu; Gao, Weihua; Du, Ming-Fei; Chu, Chao; Wang, Dan; Chen, Chen; Yuan, Yue; Liao, Yue‐Yuan; Yu, Yinhua; Wang, Keke; Zhang, Jie; Gao, Ke; Li, Chunhua; Hao, Li; Ma, Qiang; Hu, Jiawen; Zou, Ting; Sun, Yue; Li, Min; Zhou, Hao-Wei; Jia, Hao; Mu, Jianjun

doi:10.1155/2020/1638515

Cited by 9 publications

(6 citation statements)

References 44 publications

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“…In 1987, we established the cohort of Hanzhong Adolescent Hypertension Study, which was an ongoing prospective, population-based cohort study of 4,623 adolescents aimed to screen for cardiovascular risk factors that originate in childhood and adolescence. Detailed information of study has been published elsewhere (25)(26)(27)(28)(29)(30). To explore the association of serum uromodulin levels with the risk of hypertension, we used cross-sectional analysis of the latest follow-up data in 2017.…”

Section: Protocol 2: a Cross-sectional Cohort Study To Examine The Relationships Between Serum Uromodulin Levels And The Incidence Of Hypmentioning

confidence: 99%

Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Wang

Shi

et al. 2021

Front. Cardiovasc. Med.

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Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/risk.Methods: A total of 514 participants from the original Baoji Salt-Sensitive Study cohort were genotyped to examine the associations of genetic variations in uromodulin gene with the longitudinal BP changes and the incidence of hypertension over 8 years of follow-up. In addition, 2,210 subjects from the cohort of Hanzhong Adolescent Hypertension Study were used to investigate the relationships between serum uromodulin levels and the risk of hypertension.Results: SNPs rs12917707 and rs12708631 in the uromodulin gene were significantly associated with the longitudinal BP changes over 8 years of follow-up. SNP rs12708631 was significantly associated with the incidence of hypertension over 8 years. In addition, gene-based analyses supported the associations of uromodulin gene with the longitudinal BP changes and hypertension incidence in Baoji Salt-Sensitive Study cohort. Furthermore, serum uromodulin levels in the hypertensive subjects were lower than in the normotensive subjects (25.5 ± 1.1 vs. 34.7 ± 0.7 ng/mL). Serum uromodulin levels decreased gradually as BP levels increased (34.6, 33.2, 27.8, and 25.0 ng/mL for subjects with normotension, high-normal, grade 1 hypertension, and grade 2 hypertension, respectively). Serum uromodulin was significantly associated with the lower risk of hypertension [0.978 (0.972–0.984)] in Hanzhong Adolescent Hypertension Study cohort.Conclusion: This study shows that uromodulin is associated with blood pressure progression and development of hypertension.

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Section: Protocol 2: a Cross-sectional Cohort Study To Examine The Relationships Between Serum Uromodulin Levels And The Incidence Of Hypmentioning

confidence: 99%

Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Wang

Shi

et al. 2021

Front. Cardiovasc. Med.

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“…However, hyperuricemia susceptible genes are racially specific: SLC22A11, SLC16A9 and SLC17A1 only exist in Caucasians [ 10 ] while RFX3 and KCNQ have only been found in Chinese [ 11 ]. In addition, the median SUA was 279.2 μmol/L in Chinese and was 329.3 μmol/L in Caucasians [ 9 , 12 ]. Therefore, the results from Caucasians cannot be extrapolated to Chinese; and (iii) the information on the associations of SUA with essential hypertension in Chinese has been primarily from health check-up populations [ 13 ], or from small sample sized studies [ 12 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the median SUA was 279.2 μmol/L in Chinese and was 329.3 μmol/L in Caucasians [ 9 , 12 ]. Therefore, the results from Caucasians cannot be extrapolated to Chinese; and (iii) the information on the associations of SUA with essential hypertension in Chinese has been primarily from health check-up populations [ 13 ], or from small sample sized studies [ 12 , 14 ]. These “looking-good” populations are often with miscellaneous comorbidities, leading to misclassification in patients with or without hypertension, and ultimately to the unreliability of the results.…”

Section: Introductionmentioning

confidence: 99%

Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population

et al. 2022

JCDD

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Background: The association of serum uric acid (SUA) with hypertension has been well established in Caucasian populations. However, its association with hypertension in Chinese remained to be clarified. Methods: Consecutive patients, homogeneous in Chinese Han ethnicity, aged ≥18 years, abstracted from the database, admitted from 1 January 2010 to 31 December 2013, were included for potential analysis. The patients were grouped according to the presence or absence of hypertension. Unconditional logistic regression was performed to estimate the association between SUA and hypertension. Its possible interactions with risk factors on hypertension were also explored. Results: A total of 9587 patients were finally analyzed in the current study, where 5692 were with hypertension and 3895 were without hypertension. Per 100 μmol/L higher SUA concentration was associated with multivariable-adjusted odds ratios (95% CI) of 1.25 (1.08–1.22) in males, 1.10 (1.01–1.20) in females, and 1.19 (1.13–1.24) in total. On a categorical scale, when compared with the first quintile, the multivariable-adjusted odds ratios (95% CI) were 1.40 (1.20–1.64) for the 2nd quintile, 1.48 (1.27–1.74) for the 3rd quintile, 1.55 (1.32–1.82) for the 4th quintile, and 1.92 (1.63–2.26) for the 5th quintile, with a p for trend < 0.01. Conclusions: SUA is associated with hypertension in a dose-response manner among the Chinese hospitalized population. Management of SUA could help to the prevention and control of hypertension.

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“…Additionally, in a few available studies no significant relationship was found between urate and both carotid-femoraland brachial-ankle-PWV in hypertensive patients (48). On the contrary, a recent study demonstrated an association between urinary, not serum urate, and arterial stiffness in adult men (49).…”

Section: Urate and Cardiovascular Riskmentioning

confidence: 91%

The Role of Urate in Cardiovascular Risk in Adolescents and Young Adults With Hypertension, Assessed by Pulse Wave Velocity

Močnik

Jančič

Filipič

et al. 2022

Front. Cardiovasc. Med.

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BackgroundUrate is increasingly recognized as a cardiovascular risk factor. It has been associated with hypertension, metabolic syndrome, obesity, chronic kidney disease and diabetes. Its prognostic role is less clear. The aim of our study was to evaluate the association between serum urate and pulse wave velocity, a measure of arterial stiffness in hypertensive adolescents and young adults.Methods269 adolescents and young adults with hypertension were included in the study. From all, anthropometric, blood pressure, pulse wave velocity and serum urate measurements were made. Variables were compared between sex, participants with or without obesity and with or without elevated urate.ResultsIn multiple regression analysis for urate as dependent variable gender and diastolic pressure were found to be statistically significant. The difference between urate levels were found between boys and girls (p < 0.001), obese and non-obese (p < 0.001); however, pulse wave velocity did not differ between hyper- and eu-uricemic group (p = 0.162).ConclusionAssociations between urate, gender, diastolic blood pressure and obesity were confirmed, however, no significant associations between pulse wave velocity and urate were detected.

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Association of Uric Acid in Serum and Urine with Arterial Stiffness: Hanzhong Adolescent Hypertension Study

Cited by 9 publications

References 44 publications

Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults

Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population

The Role of Urate in Cardiovascular Risk in Adolescents and Young Adults With Hypertension, Assessed by Pulse Wave Velocity

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