Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population

Abstract

Background: The association of serum uric acid (SUA) with hypertension has been well established in Caucasian populations. However, its association with hypertension in Chinese remained to be clarified. Methods: Consecutive patients, homogeneous in Chinese Han ethnicity, aged ≥18 years, abstracted from the database, admitted from 1 January 2010 to 31 December 2013, were included for potential analysis. The patients were grouped according to the presence or absence of hypertension. Unconditional logistic regression was performed to estimate the association between SUA and hypertension. Its possible interactions with risk factors on hypertension were also explored. Results: A total of 9587 patients were finally analyzed in the current study, where 5692 were with hypertension and 3895 were without hypertension. Per 100 μmol/L higher SUA concentration was associated with multivariable-adjusted odds ratios (95% CI) of 1.25 (1.08–1.22) in males, 1.10 (1.01–1.20) in females, and 1.19 (1.13–1.24) in total. On a categorical scale, when compared with the first quintile, the multivariable-adjusted odds ratios (95% CI) were 1.40 (1.20–1.64) for the 2nd quintile, 1.48 (1.27–1.74) for the 3rd quintile, 1.55 (1.32–1.82) for the 4th quintile, and 1.92 (1.63–2.26) for the 5th quintile, with a p for trend < 0.01. Conclusions: SUA is associated with hypertension in a dose-response manner among the Chinese hospitalized population. Management of SUA could help to the prevention and control of hypertension.

A novel nomogram for predicting risk of hypertension in US adults with periodontitis: National Health and Nutrition Examination Survey (NHANES) 2009–2014

“…[ 45 ] And a cross-sectional study based on a Chinese population also showed that UA was dose-response associated with hypertension in the Chinese hospitalized population. [ 46 ] Our results support the findings of prior studies showing UA content is positively correlated with the risk of hypertension. There are a number of mechanisms underlying the beneficial association between UA and hypertension, including decreased endothelial nitric oxide, activation of the renin-angiotensin system, and renal microvascular disease brought on by smooth muscle cell proliferation, inflammation, and local renin-angiotensin system activation.…”

“…[45] And a cross-sectional study based on a Chinese population also showed that UA was dose-response associated with hypertension in the Chinese hospitalized population. [46] Figure 2. Nomogram for the risk of hypertension for patients with periodontitis.…”

Large-scale cross-ancestry genome-wide meta-analysis of serum urate

“…This study found that individuals with very high (99 th percentile) SU cross-ancestry PRS had 7.00-, 1.37-, and 1.34-fold higher risks of gout, heart failure, and hypertension, respectively, than those with low (0–19 th percentile) SU cross-ancestry PRS. The association between SU and hypertension, shown in previous observational studies, was also confirmed using PRS in the East Asian population 54 . These results suggest that PRS can help identify individuals with a high genetic predisposition to specific diseases associated with SU, though the predictive ability should be improved.…”

Relationship between serum uric acid and hypertension in the general US population aged 20 years and older: A cross-sectional study based on NHANES 2007 to 2016

“…Serum UA was linked to hypertension in a dose-response manner in a Chinese hospitalized population in a sizable cross-sectional investigation based on a Chinese population. [ 29 ] Another Chinese cross-sectional study that included an analysis of prehypertension found that higher serum UA levels were positively associated with prehypertension and hypertension in Chinese adults. [ 30 ] Our research revealed that the association between UA and hypertension was influenced by race.…”