Pre- and postnatal evaluation of offspring rats exposed to Origanum vulgare essential oil during mating, gestation and lactation

Hollenbach, Clarissa Boemler; Stédile, Rafael; Mello, Fabíola Peixoto da Silva; Bing, Rafaela Scheer; Rosa, Patrícia Viana da; Rodrigues, Maria Regina Alves; Mello, Fernanda Bastos de; Zanette, Régis A.

doi:10.1590/0103-8478cr20150299

Cited by 3 publications

(1 citation statement)

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“…In rats, for example, it was shown that the EO of O. vulgare may cause signs of reproductive toxicity by interfering in sperm and affecting hormonal parameters, causing infertility in male Wistar rats but only at very high doses, while moderate doses were claimed safe [59]. Moreover, these concentrations also did not affect the physical, motor, and neuroendocrine parameters of rat dams and their offspring [60].…”

Section: Discussionmentioning

confidence: 99%

A Potential Anthelmintic Phytopharmacological Source of Origanum vulgare (L.) Essential Oil against Gastrointestinal Nematodes of Sheep

Štrbac

Krnjajić

Maurelli

et al. 2022

Animals

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The development of anthelmintic resistance in sheep gastrointestinal nematodes (GINs) requires novel strategies for the sustainable control of these parasites. This study aimed to evaluate the anthelmintic efficacy of the Origanum vulgare (L.) essential oil (EO) against sheep GINs and to evaluate the possibility of its use in control practice. The in vitro egg hatch test was conducted at eight different concentrations (50, 12.5, 3.125, 0.781, 0.195, 0.049, 0.025, and 0.0125 mg/mL) of the tested EO. For the in vivo fecal egg count reduction test, the EO of O. vulgare was administrated orally at a mean single dose of 150 mg/kg to sheep from two farms in Southern Italy, whereby potential toxic effects to the hosts were also evaluated. In the egg hatch test, the inhibition of egg hatchability varied from 71.3% to 93.7%, depending on the concentration used. The high anthelmintic potential was confirmed in the fecal egg count reduction test with an average reduction of nematode eggs in feces of 43.2% and 60.1% on days 7 and 14 after treatment, respectively. In addition, no toxic effects were noticed during the clinical examination of sheep or by observing blood count and liver or kidney function test results. The obtained results suggest the strong activity of the O. vulgare EO against sheep GINs, probably due to a high percentage of carvacrol (76.21%), whereby it can be considered safe for sheep at the dose tested in vivo. Therefore, it is suitable for use in veterinary practice as a part of an integrated strategy for the control of sheep GINs.

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Section: Discussionmentioning

confidence: 99%