Evaluation of embryotoxic and teratogenic effects of the oil extracted from Caryocar brasiliense Cambess pulp in rats

Traesel, Giseli Karenina; Lima, Fernando Freitas de; Santos, Ariany Carvalho dos; Souza, Roosevelt Isaías Carvalho; Cantadori, Daniela Torres; Kretschmer, Carlos Roberto; Navarini, Vinicius João; Oesterreich, Silvia Aparecida

doi:10.1016/j.fct.2017.10.018

Cited by 13 publications

(4 citation statements)

References 26 publications

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“…Toxicity assessment is a crucial aspect, especially when considering therapeutic applications of pequi oil. In a study conducted by Traesel (2017) to evaluate maternal, embryotoxic, and teratogenic effects, the oil was administered via gavage at concentrations ranging from 250 to 1000 mg/kg/day per group until the 15th day of gestation [ 72 ]. It exhibited no signs of toxicity and had no impact on rates of reproductive, embryonic, or fetal variables, suggesting that its consumption during pregnancy is safe for both the female and the fetus.…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Activity of Pequi Oil (Caryocar brasiliense): A Systematic Review

Silva,

Pinheiro,

Ombredane

et al. 2023

Pharmaceuticals

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Disorders in the inflammatory process underlie the pathogenesis of numerous diseases. The utilization of natural products as anti-inflammatory agents is a well-established approach in both traditional medicine and scientific research, with studies consistently demonstrating their efficacy in managing inflammatory conditions. Pequi oil, derived from Caryocar brasiliense, is a rich source of bioactive compounds including fatty acids and carotenoids, which exhibit immunomodulatory potential. This systematic review aims to comprehensively summarize the scientific evidence regarding the anti-inflammatory activity of pequi oil. Extensive literature searches were conducted across prominent databases (Scopus, BVS, CINAHL, Cochrane, LILACS, Embase, MEDLINE, ProQuest, PubMed, FSTA, ScienceDirect, and Web of Science). Studies evaluating the immunomodulatory activity of crude pequi oil using in vitro, in vivo models, or clinical trials were included. Out of the 438 articles identified, 10 met the stringent inclusion criteria. These studies collectively elucidate the potential of pequi oil to modulate gene expression, regulate circulating levels of pro- and anti-inflammatory mediators, and mitigate oxidative stress, immune cell migration, and cardinal signs of inflammation. Moreover, negligible to no toxicity of pequi oil was observed across the diverse evaluated models. Notably, variations in the chemical profile of the oil were noted, depending on the extraction methodology and geographical origin. This systematic review strongly supports the utility of pequi oil in controlling the inflammatory process. However, further comparative studies involving oils obtained via different methods and sourced from various regions are warranted to reinforce our understanding of its effectiveness and safety.

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Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Activity of Pequi Oil (Caryocar brasiliense): A Systematic Review

Silva,

Pinheiro,

Ombredane

et al. 2023

Pharmaceuticals

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“…Such parameters are of great importance as reduced body weight and food and water intake are clear signs of systemic general toxicity. 29,30 Besides, pubertal exposure to endocrine-disrupting substances might lead to metabolic disorders such as exacerbated weight gain and even obesity. 31,32 When it comes to pubertal development of male and female rats, it is well known that PPS and VO are external signs of such development.…”

Section: Discussionmentioning

confidence: 99%

Effects of Talinum paniculatum (Jacq.) Gaertn. leaf extract on general toxicity and pubertal development of rats

et al. 2020

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Talinum paniculatum (Jacq.) Gaertn. (Talinaceae), popularly known as “major gomes,” is a Brazilian Cerrado plant used in traditional medicine and as a food source. Recent studies have demonstrated its diuretic effects. However, no studies have been performed on its effects on the reproductive system. Therefore, we aimed to investigate the effects of the ethanol-soluble fraction of T. paniculatum leaves (ESTP) on general toxicity and on the pubertal development of male and female Wistar rats. For this purpose, the uterotrophic and the pubertal assays were performed. In the uterotrophic test, female immature rats were treated for three consecutive days with 30, 100, or 300 mg/kg of ESTP. Uterus without luminal fluid was weighed and the relative weight calculated. For the pubertal assay, male and female immature rats were submitted to 30-day treatment with 30 or 300 mg/kg of ESTP. Clinical signs of toxicity, biochemical, and histopathological parameters were evaluated. ESTP treatment did not promote estrogenic effects in female rats. In the pubertal test, no daily signs of toxicity or weight loss were observed. Moreover, ESTP did not affect the onset of vaginal opening and preputial separation and did not cause significant changes in biochemical parameters as well as in organ weight and histopathological analyses of animals.

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“…Moreover, pequi oil intake reduces hepatic triglycerides and improves cardiac function ex vivo in male rats (Oliveira et al 2017). Toxicological investigations have indicated that oil extracts of C. brasiliense pulp present no toxicity, genotoxicity, maternal-embryo-toxic or teratogenic effects in rats (Traesel et al 2016;Traesel et al 2017a;Traesel et al 2017b).…”

Section: Caryocar Brasiliense Camb (Caryocaraceae)mentioning

confidence: 99%

Food Composition Data: Edible Plants in Cerrado

et al. 2021

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181negative correlation between the in vitro potential of many molecules and their ADME/T (absorption, distribution, metabolism, excretion/toxicity) profile is generally noted (Gleeson et al. 2011). Synthetic compounds present a significantly lower number of chiral centers and are both smaller and present greater flexibility, which results in weaker, less specific activity (Feher and Schmidt 2003). In contrast, plantderived natural products present a diversity of bioactive compounds with differing chemical scaffolds (Atanasov et al. 2015). Plant-derived products possess properties, such as binding affinities for specific proteins, that are evolutionary optimized (Appendino et al. 2010;Hunter 2008). Such characteristics make plant-derived products more advantageous for conducting ADME/T tests (Atanasov et al. 2015). Another advantage in drug discovery using medicinal plants is the known good correlation between ethnopharmacological information (well documented) and the medical use of the plant. Around 80% of identified compounds present some ethnomedicinal use, whether identical or related to current usage of the active plant elements (Fabricant and Farnsworth 2001). Further, technological advances in systems biology, bioinformatics, plant specialized metabolism, and synthetic biology present opportunities through which the medicinal properties of plants are discovered, utilized, and expanded toward developing new herb-inspired medicines (Li and Weng 2017). Accordingly, plant-derived natural products still represent a valuable source for drug discovery, this, motivated by global public health challenges, such as COVID-19, HIV/AIDS, malaria, hypertension, diabetes, and cancer (Thomford et al. 2018). About a quarter of all Food and Drug Administration (FDA)-and/or European Medical Agency (EMA)-approved drugs are plant-derived (Patridge et al. 2016;Thomford et al. 2018).In this context, Brazil possesses various biomes with a great portion of the world's biodiversity and approximately 20% of the plants and microorganisms on the planet (Calixto 2000). Among these biomes, the Cerrado is a neotropical savanna with rich flora (Klink and Machado 2005). Over 13,127 highly endemic plant species have been recorded within this biome (Myers et al. 2000;Overbeck et al. 2015;Silva and Bates 2002;Silveira et al. 2016). Yet, in regard to environmental conservation, only 41% of the original Cerrado still remains as native vegetation (Soares-Filho et al. 2014). This reduction is due to anthropogenic activities, such as monoculture, pasture expansions, mineral extraction, and the growth of urban areas (Faleiro et al. 2013). Considering only agricultural activity between 2002 and 2009, an estimated loss of 92,712 km 2 of natural Cerrado area has occurred (Overbeck et al. 2015). Preservation policies in Brazil need improvement, yet only 7% of the Cerrado is under legal protection (Soares-Filho et al. 2014).Both the bio-prospecting potential of the Cerrado for medicinal species and knowledge concerning traditional medicines are disappear...

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Evaluation of embryotoxic and teratogenic effects of the oil extracted from Caryocar brasiliense Cambess pulp in rats

Cited by 13 publications

References 26 publications

Anti-Inflammatory Activity of Pequi Oil (Caryocar brasiliense): A Systematic Review

Anti-Inflammatory Activity of Pequi Oil (Caryocar brasiliense): A Systematic Review

Effects of Talinum paniculatum (Jacq.) Gaertn. leaf extract on general toxicity and pubertal development of rats

Food Composition Data: Edible Plants in Cerrado

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