Equine acute erythroid leukemia

Abstract

Acute erythroid leukemia (AML M6) is a hematopoietic neoplasm frequently described in cats and

A review of current knowledge of myeloproliferative disorders in the horse

“…It was also found numerous mitotic erythroid cells, some of which were atypical and megaloblastic. Later, Panziera et al [ 32 ] described a case of AML-M6B in a 1-year-old filly. Clinically, the animal showed progressive weight loss, markedly pale mucous membranes, and exercise intolerance.…”

“…> 50% of the total nucleated cells in bone marrow are of erythroid lineage; at least 30% myeloblast precursors Not reported AML-M6 Acute erythroid leukemia Subtype M6B Undifferentiated or pronormoblastic immature cells the erythroid lineage > 80%. M: E ratio < 0.02:1 Forbes et al [ 32 ] Panziera et al [ 32 ] AML M7 Megakaryocytic Blast cells > 20% of the circulating cells or bone marrow and at least 30% of the marrow cells is of megakaryocyte lineage Not reported AML-M8 Acute basophilic leukemia Stain with toluidine blue. Metachromatic granules typical of mast cells or basophils Furness et al [ 37 ] Myeloproliferative neoplasms CGL Chronic granulocytic leukemia Proliferation of cell lineages of relatively mature neutrophils, eosinophils or basophils Relatively mature granulocytes predominate in blood marrow Searcy and Orr [ 38 ] Johansson et al [ 39 ] CEL Chronic eosinophilic leukemia Proliferation of eosinophil precursors with high number of eosinophils in blood, bone marrow or peripheral tissues.…”