The histopathological and immunohistochemical features of lymphoma in two Holstein cows were studied. Histologically, both cases received a diagnosis of peripheral gamma-delta T-cell lymphoma, based on positive results for CD , CD , and WC , and negative results for terminal deoxynucleotidyl transferase (TdT). In case one, the neoplastic cells had round to oval nuclei, most of which contained cytoplasmic eosinophilic granules, and a diagnosis of gamma-delta T-cell lymphoma, hypergranular variant was made. In contrast, in case two, the neoplastic cells showing variation in cell size and marked nuclear irregularity (convolution) were cytologically distinct from those in previously repor ted histological subtypes of gamma-delta T-cell lymphoma, and a diagnosis of pleomorphic gamma-delta T-cell lymphoma was made. Because this lymphoma is relatively dif ficult to distinguish cytologically from pleomorphic B cell lymphoma, immunohistochemistr y is required for dif ferential diagnosis.
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