Relationship Between Donor Quality and Recipient Gravity in Liver Transplant

Freitas, Alexandre Coutinho Teixeira de; Coelho, Júlio Cézar Uili; Watanabe, Manoelle Risnei; Lima, Rachel Lins das Chagas

doi:10.1590/0102-672020190001e1499

Cited by 5 publications

(9 citation statements)

References 16 publications

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“…According to PROBAST, 20 studies included in the DRI analysis were rated low risk of bias, 10 studies were rated high risk of bias, and in 8 studies the risk of bias was rated unclear. The risk of bias was high in five studies (50%) in the domain “Participants” [21,31,41,52,54]. In the domain “Predictors,” the risk of bias was rated high in eight studies (80%) [11,31,37,41,44,51,52,55].…”

Section: Resultsmentioning

confidence: 99%

“…In the domain “Predictors,” the risk of bias was rated high in eight studies (80%) [11,31,37,41,44,51,52,55]. The risk of bias was rated high in the domain “Outcomes” in one study (10%) [54]. Also, in the domain “Analysis,” the risk of bias was rated high in only one study (10%) [52].…”

Section: Resultsmentioning

confidence: 99%

“…Thirty studies had high applicability concerns, and 8 studies had low applicability concerns. One study had high applicability concerns in the domain “Participants” (3%) [54]. In the remaining 29 studies (97%), high applicability concerns were observed only in the domain “Outcomes” [11,20,26–29,31,33–39,41,43–46,48–53,55–57].…”

Section: Resultsmentioning

confidence: 99%

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Prognostic role of the Donor Risk Index, the Eurotransplant Donor Risk Index, and the Balance of Risk score on graft loss after liver transplantation

et al. 2021

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This study aimed to identify cutoff values for donor risk index (DRI), Eurotransplant (ET)-DRI, and balance of risk (BAR) scores that predict the risk of liver graft loss. MEDLINE and Web of Science databases were searched systematically and unrestrictedly. Graft loss odds ratios and 95% confidence intervals were assessed by meta-analyses using Mantel-Haenszel tests with a random-effects model. Cutoff values for predicting graft loss at 3 months, 1 year, and 3 years were analyzed for each of the scores. Measures of calibration and discrimination used in studies validating the DRI and the ET-DRI were summarized. DRI ≥ 1.4 (six studies, n = 35 580 patients) and ET-DRI ≥ 1.4 (four studies, n = 11 666 patients) were associated with the highest risk of graft loss at all time points. BAR > 18 was associated with the highest risk of 3-month and 1-year graft loss (n = 6499 patients). A DRI cutoff of 1.8 and an ET-DRI cutoff of 1.7 were estimated using a summary receiver operator characteristic curve, but the sensitivity and specificity of these cutoff values were low. A DRI and ET-DRI score ≥ 1.4 and a BAR score > 18 have a negative influence on graft survival, but these cutoff values are not well suited for predicting graft loss.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Prognostic role of the Donor Risk Index, the Eurotransplant Donor Risk Index, and the Balance of Risk score on graft loss after liver transplantation

et al. 2021

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“…In Brazil in 2018 the mortality rate on waitlists was 45.7% 2 . Due to that, one of the strategies has been the use of donors known as non - ideals, adjacent, with expanded criteria or bordering, in search of increasing the number of transplants and decreasing the time spent on waitlists 5 , 6 . Yet, the rate of mortality on this list is high 2,7 .…”

Section: Introductionmentioning

confidence: 99%

Bar, Soft and Dri Post-Hepatic Transplantation: What Is the Best for Survival Analysis?

Torterolli

Watanabe

Tabushi

et al. 2021

ABCD, arq. bras. cir. dig.

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Background: Liver transplantation is the treatment of choice for patients with terminal liver disease. The Balance of Risk Score (BAR), Survival Outcomes Following Liver Transplantation (SOFT) and Donor Risk Index (DRI) scores are predictive systems for post-transplant survival. Aim: To evaluate the most accurate score and the best cutoff point for each predictor in the brazilian population. Method: Retrospective cross-sectional study of 177 patients. Data on the recipient, donor and transplant were analyzed and the prognostic scores BAR, SOFT and DRI were calculated for each transplant. To determine the BAR and SOFT cutoff points associated with death in three months, ROC curves were adjusted. Results: The best cutoff point for BAR was 9 points with an area under the ROC curve=0.69 and for SOFT it was 12 points with an area under the ROC curve=0.73. The DRI score did not discriminate survival (p = 0.139). Conclusion: The SOFT score proved to be better than BAR for survival analysis post-hepatic transplantation and the DRI was not effective.

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“…It is the 8 th most common cause of mortality in the United States and 13 th worldwide, with 45.6% increase in mortality. It is generally considered irreversible in its more advanced stages, for which the only definitive treatment is liver transplantation 7 .…”

Section: Introductionmentioning

confidence: 99%

Cirrhotic Patients With Acute Kidney Injury (Aki) Have Higher Mortality After Abdominal Hernia Surgery

Ducatti

Haddad

Meyer

et al. 2021

ABCD, arq. bras. cir. dig.

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Background: The incidence of abdominal hernia in cirrhotic patients is as higher as 20%; in cases of major ascites the incidence may increase up to 40%. One of the main and most serious complications in cirrhotic postoperative period (PO) is acute kidney injury (AKI). Aim: To analyze the renal function of cirrhotic patients undergoing to hernia surgery and evaluate the factors related to AKI. Methods: Follow-up of 174 cirrhotic patients who underwent hernia surgery. Laboratory tests including the renal function were collected in the PO.AKI was defined based on the consensus of the ascite´s club. They were divided into two groups: with (AKI PO) and without AKI . Results: All 174 patients were enrolled and AKI occurred in 58 (34.9%). In the AKI PO group, 74.1% had emergency surgery, whereas in the group without AKI PO it was only 34.6%.In the group with AKI PO, 90.4% presented complications, whereas in the group without AKI PO they occurred only in 29.9%. Variables age, baseline MELD, baseline creatinine, creatinine in immediate postoperative (POI), AKI and the presence of ascites were statistically significant for survival. Conclusions: There is association between AKI PO and emergency surgery and, also, between AKI PO and complications after surgery. The factors related to higher occurrence were initial MELD, basal Cr, Cr POI. The patients with postoperative AKI had a higher rate of complications and higher mortality.

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Relationship Between Donor Quality and Recipient Gravity in Liver Transplant

Cited by 5 publications

References 16 publications

Prognostic role of the Donor Risk Index, the Eurotransplant Donor Risk Index, and the Balance of Risk score on graft loss after liver transplantation

Prognostic role of the Donor Risk Index, the Eurotransplant Donor Risk Index, and the Balance of Risk score on graft loss after liver transplantation

Bar, Soft and Dri Post-Hepatic Transplantation: What Is the Best for Survival Analysis?

Cirrhotic Patients With Acute Kidney Injury (Aki) Have Higher Mortality After Abdominal Hernia Surgery

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