Use of surgical mesh of different compositions in the correction of the abdominal wall defect in rats

Isa, Ana Cristina; Matias, Jorge Eduardo Fouto; Yamamoto, Célia Toshie; Isa, Rosana Hapsi; Campos, Antônio Carlos Ligocki; Coelho, Júlio Cézar Uili

doi:10.1590/0100-69912015005011

Cited by 3 publications

(4 citation statements)

References 23 publications

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“…The dyes used in bone marrow smears are different from H&E of routine histological sections. The bone marrow in response to the continued release of cytokines presents an increase in reticular fibers, which can be highlighted by another classic coloring, picrosirius 11 . Often the immunophenotyping is essential for the differential diagnosis and evaluation of the megakariocytic lineage, since hematopoietic cells contain several antigens; the immunophenotyping by flow cytometry can identify various antigens using specific monoclonal antibodies, which receive the name of “clusters of differentiation” (CD), followed by a specific number.…”

Section: Discussionmentioning

confidence: 99%

“…Polypropylene is used since Usher pioneer work in 1958 and several options have been developed aiming at reducing inflammatory response to the implantation, like the diminishing used grammature of used material or the association of a smaller polypropylene framework to other absorbing material. However, triggered inflammatory response is significant, even with different materials available nowadays 2 , 3 , 11 , 16 , 22 , 25 , 29 .…”

Section: Introductionmentioning

confidence: 99%

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Stem Cells Hematopoietic Niches and Inflammatory Response to Different Synthetic Prosthesis Implanted in Rat With Incisional Hernias

Barbieri

Parreira

Studart

et al. 2017

ABCD, arq. bras. cir. dig.

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Background: Extramedullary hematopoiesis depends on complex pathophysiological mechanisms linked to hematopoietic stem cells and the proteins considered mediators of the inflammation. The identification of hematopoietic cells outside bone marrow in the adult is an occurrence that can occasionally follows the inflammatory response, was considered a secondary occurrence, but current biomolecular studies have changed that concept. Aim: Describe the presence of clusters of precursor cells of platelets (megakaryocytes), and cells of the inflammatory response in the abdominal wall and spleen of rats with experimentally induced incisional hernias and repaired with different synthetic prostheses. Methods: Twenty-five rats with incisional hernias previously performed, were divided into groups of five animals each: Group 1, repair of the hernia defect without prosthetic implant; Group 2, repair with polypropylene prosthesis; Group 3, repair using polypropylene with low weight; Group 4, the use of polypropylene and polyglecaprone prosthesis; Group 5, of polypropylene and polyglactin prosthesis. All prostheses were cut in rhombus format with area 2,625 cm². The animals were reoperated after 10 days, the abdominal walls were removed with the viscera attached to them and the material was processed for histological study. Results: Megakaryocyte niches in the abdominal wall and spleen, occasionally removed together with the adhesions produced in animals with implantation of prostheses and significant inflammatory reaction. Conclusion: The intense inflammatory reaction due to the prostheses with polypropylene in their composition was disproportionate to the expected response, indicating that further studies should be accomplished including immunophenotyping evaluation and specific panels of monoclonal antibodies to better understand the findings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stem Cells Hematopoietic Niches and Inflammatory Response to Different Synthetic Prosthesis Implanted in Rat With Incisional Hernias

Barbieri

Parreira

Studart

et al. 2017

ABCD, arq. bras. cir. dig.

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“…The search for adequate solutions for the lasting correction of hernias is frequent among surgeons, because, however small the defect, there will always be tension in the repair of the surgical wound. Thus, the reduction of this tension in the suture line is one of the objectives of the various techniques available for abdominal wall reconstruction 7 - 10 .…”

Section: Introductionmentioning

confidence: 99%

Relaxation incisions and tensile strength in the abdominal wall of pigs

Pedroso

Melo²,

Oliveira³

2019

Acta Cir. Bras.

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Purpose To analyze the resistance to medial traction of abdominal wall muscles, before and after performing relaxing incisions. Methods Seventeen live pigs were used. After a median laparotomy, the handles were made in the rectus abdominis muscles (RAM) to fit the dynamometer. Step 1 (control phase): tensile strength measured without performing relaxant incisions. Step 2: A curvilinear relaxant incision was made on the anterior blade of the right RAM sheath and then the tensile strength was measured by the edge of the wound. The same procedure was adopted after incision of the left posterior blade. Step 3: Relaxing incisions were made in the right posterior and left anterior blade, so that both sides were left with a relaxing incision on both blades. Measurements of resistance were performed. Results There was no statistically significant difference between the sides. On the right and left side, all treatments reduced the tensile strength when compared to each other and to the control. There was a reduction of 12% and 9.8% after incision of the anterior and posterior blade, respectively. Conclusion Relaxing incisions reduced tensile strength in the ventral abdominal wall.

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“…Among the main risk factors for its appearance, are wound infection and obesity, among others [1][2][3] .…”

Section: Introductionmentioning

confidence: 99%

Ventral abdominal wall defect correction in rats with contaminated meshes

et al. 2016

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Use of surgical mesh of different compositions in the correction of the abdominal wall defect in rats

Abstract: the meshes retain similarities in the final result and more studies with larger numbers of animals must be carried for better assessment.

Cited by 3 publications

References 23 publications

Stem Cells Hematopoietic Niches and Inflammatory Response to Different Synthetic Prosthesis Implanted in Rat With Incisional Hernias

Stem Cells Hematopoietic Niches and Inflammatory Response to Different Synthetic Prosthesis Implanted in Rat With Incisional Hernias

Relaxation incisions and tensile strength in the abdominal wall of pigs

Ventral abdominal wall defect correction in rats with contaminated meshes

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