Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.

Campos, Fernanda Fraga; Sales, Policarpo Ademar; Romanha, Álvaro J.; Araújo, Márcio Sobreira Silva; Siqueira, Ezequias Pessoa de; Resende, Jarbas M.; Alves, Tânia Maria de Almeida; Martins‐Filho, Olindo Assis; Santos, Vera Lúcia dos; Rosa, Carlos A.; Zani, Carlos L.; Cota, Betânia Barros

doi:10.1590/0074-02760140243

Cited by 52 publications

(25 citation statements)

References 40 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study also highlighted the relationship between phenolic and flavonoid content to the antioxidant nature of the natural products. Our study is in agreement with the studies reported earlier about the positive correlation between the phenolic content and the antioxidant potential of natural products (Ben et al 2009; Yadav et al 2014; Campos et al 2015). …”

Section: Discussionsupporting

confidence: 94%

Antiangiogenic, wound healing and antioxidant activity ofCladosporium cladosporioides(Endophytic Fungus) isolated from seaweed (Sargassum wightii)

et al. 2016

View full text Add to dashboard Cite

Endophytic fungi from marine seaweeds are the less studied group of organisms with vast medical applications. The aim of the present study was to evaluate antioxidant, antiangiogenic as well as wound healing potential of the endophytic fungus isolated from the seaweed Sargassum wightii. The morphological characters and the rDNA internal transcribed spacer sequence analysis (BLAST search in Gen Bank database) was used for the identification of endophytic fungus. The antioxidant potential of the ethyl acetate extract of endophytic fungus was assessed by, 1,1-diphenyl-2-picryl-hydrazyl radical scavenging method. The fungal extract was also analysed for reducing power, total phenolic and flavonoid content. Antiangiogenic activity of the fungal extract was studied in vitro by inhibition of wound healing scratch assay and in vivo by Chick chorioallantoic membrane assay. The endophytic fungus was identified as Cladosporium cladosporioides (Gen Bank ID – KT384175). The ethyl acetate extract of C. cladosporioides showed a significant antioxidant and angiosuppressive activity. The ESI-LC-MS analysis of the extract revealed the presence of wide range of secondary metabolites. Results suggest that C. cladosporioides extract could be exploited as a potential source for angiogenic modulators.

show abstract

Section: Discussionsupporting

confidence: 94%

Antiangiogenic, wound healing and antioxidant activity ofCladosporium cladosporioides(Endophytic Fungus) isolated from seaweed (Sargassum wightii)

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Fungi of the genus Xylaria are often isolated as endophytic from tropical plants and their metabolites have antibacterial activity, as observed in prospecting studies (Souza et al, 2004;Campos et al, 2015).…”

Section: Discussionmentioning

confidence: 96%

Antibacterial activity of endophytic fungi isolated from Croton lechleri (Euphorbiaceae)

Vargas¹,

Albuquerque²,

Ribeiro³

et al. 2018

J. Med. Plants Res.

View full text Add to dashboard Cite

Croton lechleri is a native species from the Amazon and used with relative frequency in folk medicine in Brazil and other countries. Diversity and antibacterial activity of endophytic fungi associated with this plant were studied here. Samples of leaves and stems were used and 575 endophytic fungi were isolated (307 from leaves and 268 from stems), comprising 284 morphotypes distributed in 13 genera and unknown. The most frequently isolated genera were Phomopsis (30.78%), Penicillium (21.57%) and Pestalotiopsis (16.70%). Diversity and richness of species were higher in leaf tissues. Fifty-five fungi presented antibacterial activity. The fungi with the highest activity were Phomopsis (6.34%), Penicillium (3.17%), and those unknown (5.28%). Penicillium sp. 9 showed the highest antibacterial activity against Enterococcus faecalis and Phomopsis sp. 8 and Phomopsis sp. 9 against Streptococcus pneumoniae and Staphylococcus aureus. Curvularia sp. 1 and a fungus that could not be identified (Unknown sp. 9), showed the highest antibacterial activity against Klebsiella pneumoniae and Escherichia coli, respectively. Only two fungi (Penicillium sp. 9 and Curvularia sp. 1) inhibited the five tested bacteria. Endophytic fungi of C. lechleri harbor a great diversity of endophytic fungi, which have the potential for producing antibacterial compounds.

show abstract

“…Asterosporium and Aureobasidium were isolated only at 18°C, while Guignardia, Aspergillus, Botrytis, and Didymostilbe only at 28°C. Studies on endophytic fungi generally use temperatures between 25 and 28°C (Premalatha and Kalra, 2013;Campos et al, 2015;Ferreira et al, 2015).…”

Section: Isolation and Identification Of Endophytic Fungimentioning

confidence: 99%

Antibacterial activity of endophytic fungi from the medicinal plant Uncaria tomentosa (Willd.) DC

Rodrigues¹,

Araujo²,

Cunha³

et al. 2018

J. Med. Plants Res.

View full text Add to dashboard Cite

This study was designed to determine the diversity and antibacterial activity of endophytic fungi isolated from Uncaria tomentosa. Leaf and stem were disinfected superficially and inoculated in PDA and SDA medium, with and without plant extract and incubated at 18 and 28°C for isolation of endophytic fungi. Endophytic fungi were inoculated in BD medium and the metabolites extracted with ethyl acetate. Endophytic fungi extracts were tested for antibacterial activity by the disk diffusion test. One hundred and seventy endophytic fungi were isolated and identified as Aspergillus, Asterosporium, Aureobasidium, Botrytis, Colletotrichum, Curvularia, Didymostilbe, Fusarium, Guignardia, Nigrospora, Penicillium, Pestalotiopsis, Phomopsis, and sterile mycelium. Staphylococcus aureus was the most resistant bacterium, with only two fungal extracts inhibiting its growth, while the most sensitive was Escherichia coli, with 23 extracts inhibiting its growth. Five extracts inhibited Enterococcus faecalis and four Klebsiella pneumoniae. No fungal extract was able to inhibit the four tested bacteria. Extracts from endophytic fungi isolated from U. tomentosa showed in vitro antibacterial activity against grampositive and gram-negative bacteria.

show abstract

Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.

Cited by 52 publications

References 40 publications

Antiangiogenic, wound healing and antioxidant activity ofCladosporium cladosporioides(Endophytic Fungus) isolated from seaweed (Sargassum wightii)

Antiangiogenic, wound healing and antioxidant activity ofCladosporium cladosporioides(Endophytic Fungus) isolated from seaweed (Sargassum wightii)

Antibacterial activity of endophytic fungi isolated from Croton lechleri (Euphorbiaceae)

Antibacterial activity of endophytic fungi from the medicinal plant Uncaria tomentosa (Willd.) DC

Contact Info

Product

Resources

About