Modifiable factors of vitamin D status among a Brazilian osteoporotic population attended a public outpatient clinic

Camargo, Marília Brasílio Rodrigues; Kunii, llda Sizue; Hayashi, Lilian Fukusima; Muszkat, Patricia; Anelli, Catherine Gusman; Marin-Mio, Rosângela Villa; Martini, Lígia Araújo; França, Natasha Aparecida Grande de; Lazaretti-Castro, Marise

doi:10.1590/0004-2730000003393

Cited by 5 publications

(3 citation statements)

References 40 publications

(61 reference statements)

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“…The present crosssectional study used the baseline data from all these women as they entered the study protocols, which were conducted by the same professionals and utilized the same methodology for measurement of antrhopometric and body composition parameteres. The selection criteria for choosing study participants are described in details in the publications resulting from these three studies (9)(10)(11). For further analysis, these women were divided into two groups: 430 that were undergoing treatment for osteoporosis (47 to 87 years old, average of 68.3 ± 8.2 years old) (10,11) and 513 never treated for osteoporosis (41 to 87 years old, average of 65.8 ± 7.4 years old) (9,11).…”

Section: Methodsmentioning

confidence: 99%

Lean mass as a determinant of bone mineral density of proximal femur in postmenopausal women

Marin-Mio¹,

Moreira²,

Camargo³

et al. 2018

Archives of Endocrinology and Metabolism

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Objective: To verify which component of body composition (BC) has greater influence on postmenopausal women bone mineral density (BMD). Subjects and methods: Four hundred and thirty women undergoing treatment for osteoporosis and 513 untreated women, except for calcium and vitamin D. Multiple linear regression analysis was performed in order to correlated BMD at lumbar spine (LS), total femur (FT), femoral neck (FN) with body mass (BM), total lean mass (LM) and total fat mass (FM), all determined by DXA. Results: BM significantly correlated with all bone sites in untreated and treated women (r = 0.420 vs 0.277 at LS; r = 0.490 vs 0.418 at FN, r = 0.496 vs 0.414 at FT, respectively). In untreated women, the LM correlated better than FM with all sites, explaining 17.9% of LS; 32.3% of FN and 30.2% of FT; whereas FM explained 13.2% of LS; 27.7% of FN, 23.4% of FT. In treated women, correlations with BC were less relevant, with the LM explaining 6.7% of BMD at LS; 15.2% of FN, 16% of FT, whereas the FM explained 8.1% of LS; 17.9% of FN and 17.6% of FT. Conclusion: LM in untreated women was better predictor of BMD than FM, especialy for distal femur, where it explained more than 30% of the BMD, suggesting that maintaining a healthy muscle mass may contribute to decrease osteoporosis risk. Treatment with anti-osteoporotic drugs seems to mask these relationships.

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Section: Methodsmentioning

confidence: 99%

Lean mass as a determinant of bone mineral density of proximal femur in postmenopausal women

Marin-Mio¹,

Moreira²,

Camargo³

et al. 2018

Archives of Endocrinology and Metabolism

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“…Many studies demonstrated that HIV positive population is more likely to have 25-OH-vitamin D deficiency in contrast to HIV negative subjects. Besides classic risk factors like reduced exposure to light, low vitamin D intake diet, female sex, high BMI, hyperparathyroidism, there may be some HIV-related factors for vitamin D levels disturbances [26,27]. The mechanism responsible for low vitamin D levels in HIV infected subjects is not clear.…”

Section: Resultsmentioning

confidence: 99%

Untitled

2019

FARMACIA

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The aim of this study was to determine the prevalence and risk factors for osteopenia and osteoporosis among HIV infected patients from the Romanian cohort. We performed a cross-sectional study over a three-year period on HIV positive patients from the Romanian cohort which were in National Institute of Infectious Diseases "Prof. Dr. Matei Balș", Bucharest, Romania evidences. We calculated patient`s body mass index (BMI), we determined CD4 cell count, HIV viral load and 25-OH-vitamin D plasma levels. All patients had whole body bone mineral density (BMD) measured by Dual X-Ray Absorptiometry (DXA) scan and 29 of them also had hip and lumbar spine DXA scan. We enrolled 46 patients, 25 females. According to the T score at whole body examination 14 and 3 patients were diagnosed with osteopenia and osteoporosis, respectively. Lumbar spine osteopenia and osteoporosis were diagnosed in 7 and 2 patients, respectively. Hip osteopenia and osteoporosis were diagnosed in 4 and 2 patients, respectively. Regarding the Z score, 3 patients had values below the expected range at whole body examination and 2 had low values at both hip and lumbar spine. In patients with detectable HIV viral load low whole-body BMD was negatively correlated with HIV viremia. Patients with low plasma 25-OH-vitamin D levels had lower whole-body Z score means and those with viral hepatitis co-infections had lower lumber spine T and Z score means. High HIV viral load, low vitamin D levels and viral hepatitis co-infections may be indicators for BMD disturbances in patients with HIV infection. RezumatObiectivul studiului a fost determinarea prevalenței și a factorilor de risc pentru instalarea osteopeniei și a osteoporozei la pacienții HIV pozitivi din cohorta românească. Am înrolat într-o perioadă de 3 ani pacienți infectați HIV din cohorta românească aflați în evidența Institutului Național de Boli Infecțioase "Prof. Dr. Matei Balș", București, România. Am calculat indicele de masă corporală (IMC) și am recoltat probe sangvine pentru a determina numărul celulelor CD4, viremia HIV și nivelul 25-OH-vitaminei D. Densitatea minerală osoasă (DMO) a fost evaluată prin Dual X-Ray Absorptiometry (DXA). Toți pacienții au efectuat whole body DXA, iar 29 au efectuat și DXA coloană lombară și șold bilateral. Am înrolat 46 de pacienți dintre care 25 de femei. Conform scorului T la examinarea whole body 14 aveau osteopenie și 3 osteoporoză, la examinarea coloanei lombare 7 aveau osteopenie și 2 osteoporoză. La examinarea șoldului 4 pacienți aveau osteopenie și 2 osteoporoză. Conform scorului Z la examinarea whole body, 3 pacienți au avut DMO scăzută, iar la examinarea șoldului și a coloanei lombare, 2 au avut DMO scăzută. La pacienții cu viremie detectabilă valoarea viremiei s-a corelat negativ cu DMO obținută la whole body DXA. Media scorurilor Z la examinarea whole body a fost mai scăzută la pacienții cu valori mici ale 25-OH-vitaminei D, iar pacienții co-infectați cu virusuri hepatitice au avut media scorurilor T și Z de la coloana lombară mai scăzută. Încărcatur...

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“…The evolution of osteoporosis and associated fractures are conditioned by some risk factors [5][6][7][8][9][10] , which lead to an osteometabolic imbalance caused by the deficiency of essential nutrients to maintain active bone metabolism, with the main nutrients being calcium and vitamin D 7,11,12 .…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and bone health in adults: a systematic review and meta-analysis

Segheto

Pereira

Silva

et al. 2021

Ciênc. saúde coletiva

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Low bone health is associated with vitamin D deficiency in older individuals; however, this association is not well established in adults. The aim of the study was to analyze the association between serum concentrations of 25-hydroxyvitamin D and bone health in adults by systematic review and meta-analysis. The search was carried out in the LILACS, PubMed, Scopus, Web of Science, ScienceDirect databases from March 2017 to October 2018 with adult individuals (20-59 years). Bone health was evaluation performed through dual X-ray absorptiometry and serum concentrations of 25(OH)D. The random effect model was used to analyze data from bone mineral content and bone mineral. Random effects models were used and the sources of heterogeneity were explored by means of meta-regression. Thirty-five articles were selected. There was positive correlation between vitamin D and bone health in most of the evaluated sites. Correlation was observed in the analysis of subgroups for lumbar spine among men. When stratified, the studies presented high heterogeneity, which was explained by the sample size, mean serum vitamin D levels and risk of bias. Vitamin D is positively correlated to bone health in adult individuals.

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Modifiable factors of vitamin D status among a Brazilian osteoporotic population attended a public outpatient clinic

Cited by 5 publications

References 40 publications

Lean mass as a determinant of bone mineral density of proximal femur in postmenopausal women

Lean mass as a determinant of bone mineral density of proximal femur in postmenopausal women

Untitled

Vitamin D and bone health in adults: a systematic review and meta-analysis

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