Vitamin D and bone health in adults: a systematic review and meta-analysis

Abstract

Low bone health is associated with vitamin D deficiency in older individuals; however, this association is not well established in adults. The aim of the study was to analyze the association between serum concentrations of 25-hydroxyvitamin D and bone health in adults by systematic review and meta-analysis. The search was carried out in the LILACS, PubMed, Scopus, Web of Science, ScienceDirect databases from March 2017 to October 2018 with adult individuals (20-59 years). Bone health was evaluation performed through dual X-ray absorptiometry and serum concentrations of 25(OH)D. The random effect model was used to analyze data from bone mineral content and bone mineral. Random effects models were used and the sources of heterogeneity were explored by means of meta-regression. Thirty-five articles were selected. There was positive correlation between vitamin D and bone health in most of the evaluated sites. Correlation was observed in the analysis of subgroups for lumbar spine among men. When stratified, the studies presented high heterogeneity, which was explained by the sample size, mean serum vitamin D levels and risk of bias. Vitamin D is positively correlated to bone health in adult individuals.

Association Between Vitamin D Level and Z-Score Changes of Bone Density in College-Age Saudi Girls: A Cross-Sectional Study

“…The majority of the results showed a positive correlation. 31 In our study, we measured only the total 25(OH)D. The free VD is a portion of VD in circulation that is unbound to protein. Around 85-90% of the total VD in circulation is bound to its specific binding protein (DBP) and (weakly) to plasma albumin (10-15%), leaving a small fraction (< 1%) in its "free form".…”

Vitamin D, Menopausal Health and COVID-19: Critical Appraisal of Current Data

“…Finally, the association of VDD with decreased bone mineral density (BMD) in adults is clear at any skeletal site (i.e., hip and spine) where BMD was assessed [17]. This association has also been found in postmenopausal women, independent of ethnic origin [18,19].…”

Vitamin D: The Challenge of Bridging the Gap and the Rationale for Supplementation

“…Table 2 presents summary data by health condition from key randomised controlled trials (RCTs) and meta-analyses over the past 10 years. Whilst findings from RCTs are often used to infer causation, it is important to consider that epidemiological studies evaluate links across longer time frames, without such large differences in vitamin D intake and can better represent a With regards to bone health and bone density, many studies indicate a positive effect of vitamin D supplementation on bone density [66][67][68] but inconsistencies exist across a few studies [69]. Again, findings with regards to falls and fractures are inconsistent, but vitamin D supplementation in doses of 800-1000 IU (20-25mcg) daily with adequate calcium intake can decrease the incidence of fractures in elderly, vitamin D deficient subjects [70,71].…”