Zingiber officinale formulation reduces hepatic injury and weight gain in rats fed an unhealthy diet

Abstract

this study investigated the ability of formulation containing Zingiber officinale (ginger) to reverse health changes promoted by unhealthy diet in Wistar rats. Five compounds from the gingerol family and three from the shogaol family were identified in the chromatographic analyzes of the extract. the animals were fed a combination of unhealthy foods, the cafeteria diet, which promoted increases in body weight, hepatocyte nucleus area, total hepatocyte area and liver fat accumulation, as well as reduced hepatic glutathione S-transferase concentration, compared to the control group, which received commercial chow. the treatment with ginger improved all these results, highlighting the reduction of 10% of body weight and 66% of the total area of lipid droplets deposited, compared to the group that received the cafeteria diet. Ginger treatments also attenuated lipid peroxidation, with a mean reduction of 41% in malondialdehyde levels and a mean increase of 222% in glutathione S-transferase activity in the liver. the cafeteria diet and ginger extract did not promote significant changes in glycemic and lipid profile, liver weight and liver enzymes compared to the control group. We suggest that ginger can have beneficial effects on health complications associated with unhealthy diet, such as excessive adiposity, oxidative stress and hepatic injury.

Zingerone ameliorates non‐alcoholic fatty liver disease in rats by activating AMPK

“…In addition, Zingerone prevented hepatic steatosis attenuated dyslipidemia and the increase in the levels of the circulatory transaminases in HFD and sucrose‐induced NAFLD in rodents, as well as in alcohol‐fed rats (Muhammad et al, 2021b). Daily consumption of the ginger power also attenuated dyslipidemia and improved levels of liver marker enzymes in patients with NAFLD (Leal et al, 2019; Rafie et al, 2020). In addition, the treatment with ginger prevented weight gain, reduced fat deposits, and attenuated liver injury by suppressing lipid peroxidation and upregulating antioxidant enzymes in rats fed unhealthy diet.…”

A systematic review and meta‐analysis of preclinical and clinical studies on the efficacy of ginger for the treatment of fatty liver disease

“…Finally, 20 eligible studies were identified, of which 17 in-vivo experiments were included in the quantitative analysis/meta-analysis (Bin-Meferij, Shati, Eid, & El-Kott, 2017;Chang, Liou, Tzeng, & Liu, 2014;Faran et al, 2019;H. Gao et al, 2012;Heeba & Abd-Elghany, 2010;Kandeil, Hashem, Mahmoud, Hetta, & Tohamy, 2019;Lai et al, 2016;Leal et al, 2019;Lee, Ahn, Jang, Ha, & Jung, 2016;Liu, Huo, Zhang, & Zhang, 2003;Nammi et al, 2010 Abbreviations: C57BL/6, C57 black 6, NAFLD, non-alcoholic fatty liver disease; TC, total cholesterol; TG, triglycerides.…”

“…When full‐text articles were assessed for eligibility criteria, a total of 75 studies were excluded. Finally, 20 eligible studies were identified, of which 17 in‐vivo experiments were included in the quantitative analysis/meta‐analysis (Bin‐Meferij, Shati, Eid, & El‐Kott, 2017; Chang, Liou, Tzeng, & Liu, 2014; Faran et al, 2019; H. Gao et al, 2012; Heeba & Abd‐Elghany, 2010; Kandeil, Hashem, Mahmoud, Hetta, & Tohamy, 2019; Lai et al, 2016; Leal et al, 2019; Lee, Ahn, Jang, Ha, & Jung, 2016; Liu, Huo, Zhang, & Zhang, 2003; Nammi et al, 2010; Nwozo, Osunmadewa, & Oyinloye, 2014; Sakr, Mahran, & Lamfon, 2011; Sharma & Singh, 2012; Shirpoor et al, 2018; Tzeng, Liou, Chang, & Liu, 2013; Seo, Fang, & Kang, 2021). 3 clinical trials were included in the qualitative analysis (Nayebi Far & Ghasemi, 2021; Rafie, Hosseini, Hajiani, Saki Malehi, & Mard, 2020; Rahimlou, Yari, Hekmatdoost, Alavian, & Keshavarz, 2016).…”

Is 6-Shogaol a Beneficial Phytochemical for Patients with Lower-Risk Myelodysplastic Syndrome? A Narrative Review

“…The hepatoprotective effects of ginger were seen in ameliorating age-related changes (Mahmoud & Hegazy, 2016), reducing liver injury due to unhealthy diet and alcohol (Leal et al, 2019;Zhuang et al, 2015), and improving chemicalinduced hepatotoxicity and liver fibrosis in many in vivo studies (Badawi, 2019;El-Sharaky et al, 2009;Elzwi, 2019;Essawy et al, 2018;Motawi et al, 2011;Mukherjee et al, 2015;Sabina et al, 2011). These studies commonly reported improved aspartate aminotransferase and alanine aminotransferase enzyme levels and preserved hepatocyte structure after ginger administration (Badawi, 2019;Elzwi, 2019;Motawi et al, 2011).…”