A systematic review and meta‐analysis of preclinical and clinical studies on the efficacy of ginger for the treatment of fatty liver disease

Abstract

Fatty liver disease (FLD) is the most common chronic liver disease worldwide. The pathogenesis of this disease is closely related to obesity and insulin resistance.Ginger has hypolipidemic and antioxidant effects and acts as an insulin sensitizer.This study aims to evaluate the effect of ginger supplementation on the fatty liver.A comprehensive search of Medline/PubMed, Embase, Scopus, Web of Science/ ISI, and Cochrane databases was conducted without time or language restrictions. Eighteen eligible studies were identified, including 17 in-vivo experiments in quantitative analysis and 3 clinical trials in qualitative analysis. The present study provides comprehensive evidence of the efficacy of ginger to improve the liver levels of cholesterol (À5.60 mg/g), triglycerides (TG, À4.28 mg/g), malondialdehyde (À3.16 nmol/mg), catalase (CAT) (3.35 nmol/mg), superoxide dismutase (SOD, 3.01 U/mg), serum levels of alanine aminotransferase (ALT, À2.85 U/L), aspartate aminotransferase (AST, À0.98 U/L), TG (À4.98 mg/dL), low-density lipoprotein (LDL, À3.94 mg/dL), total cholesterol (TC, À3.45 mg/dL), high-density lipoprotein (HDL, 1.27 mg/dL), and fasting blood sugar (FBS, À2.54 mg/dL). Ginger administration may reduce many clinical aspects of FLD by several mechanisms, including insulin-sensitive effects, stimulating the expression of antioxidant enzymes, reducing the generation of reactive oxygen species (ROS), having antidyslipidemic activities, and reducing hepatic fat content. However, future clinical trials are essential to investigate the clinical application of ginger in this area.

The effects of medicinal and food homologous substances on blood lipid and blood glucose levels and liver function in patients with nonalcoholic fatty liver disease: a systematic review of randomized controlled trials

“…Currently, there is a growing trend of systematic evaluations being conducted on medicinal and food homologous substances both domestically and internationally [ 31 – 33 ]. However, they are all focused on a single substance and have not been discussed and analyzed from the category of medicinal and food homologous substances.…”

Natural products from food sources can alter the spread of AMR plasmids inEnterobacterales

“…Certain food products and their bioactive constituents possess diverse physiological effects. For example, ginger has been reported to have protective effects on gastrointestinal, nervous, and cardiovascular systems (13), displays antimicrobial effects (14), and has been associated with improved outcomes in fatty liver diseases (15). Similarly, black pepper and turmeric extracts have been reported to have diverse physiological effects in vitro and in vivo , including anti-tumorigenic, anti-diarrhoeal, antioxidant, and antimicrobial effects (16, 17).…”

Nonalcoholic steatohepatitis: A comprehensive updated review of risk factors, symptoms, and treatment

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