Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio in Missed Abortion

Abstract

Objective Missed abortion occurs in ∼ 15% of all clinical pregnancies. The pathogenesis is not clearly known. However, defective placentation resulting in maternal systemic inflammatory response is considered responsible for missed abortion. Platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) are increasingly cited parameters of inflammation in the literature. However, no study evaluated the PLR and NLR rates in missed abortions so far. The aim of the present study is to investigate whether complete blood count (CBC) inflammatory parameters such as NLR and PLR are increased in patients with missed abortion. Methods Medical records of 40 pregnant women whose gestation ended in missed abortion at between 6 and14 weeks of gestation and of 40 healthy pregnant women were collected and compared retrospectively. The groups were compared regarding hemoglobin, hematocrit, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), PLR and NLR. Results Platelet distribution width, NLR and PLR values were higher in the missed abortion group compared with the healthy pregnant women group (rates are p = 0.043; p = 0.038; and p = 0.010, respectively). Hematocrit, MPV, and lymphocyte values were found to be lower in the missed abortion group compared with the healthy pregnant women group (p = 0.027, p = 0.044 and p = 0.025, respectively). Conclusion The PDW, NLR and PLR values of the missed abortion group were reported high; and MPV values were reported low in the present study. These findings may help to speculate a defective placentation in the pathogenesis of missed abortion.

Clinical Efficacy and Safety Study of Mifepristone with Misoprostol Treatment in Patients with Missed Abortion

“…The incidence of MA in China has been on the rise in recent years due to factors such as rising life stress and deterioration of living environment [ 2 ]. Clearance is the main treatment for MA, but the death of the embryo absorbs a large amount of amniotic fluid causing organization of the tissue, and the necrotic tissues may form a tight connection with the uterine wall and cannot be completely detached from the uterine wall, which can lead to difficulty in scraping or hemorrhage after the scraping procedure [ 3 ]. If the pregnancy tissue remains in the uterine cavity for a longer period of time, it can also lead to tissue lysis and release of large amounts of hemolysin into the blood circulation of the pregnant woman, causing a coagulation disorder, which can cause massive uterine bleeding and even lead to diffuse intravascular coagulation [ 4 ].…”

Kisspeptin and Hematologic Parameters as Predictive Biomarkers for First-Trimester Abortions

“…The associations of hematologic markers with abortion status of early pregnancy were published in previous studies. In a study performed by Biyik et al 34 , NLR and PLR values of a missed abortion group were found to be increased compared with healthy pregnant women. Ata et al 35 also noticed that PLR was a significant predictor for early pregnancy loss and threatened miscarriage, whereas NLR was not.…”

The value of Neutrophil gelatinase-associated lipocalin and Neutrophil / Lymphocyte Ratio in the diagnosis of preeclampsia and its severity

“…The value of N / L in pregnancy was discussed in terms of predicting pregnancy outcomes in the first trimester. A study by Biyik I et al showed a higher ratio in cases with missed miscarriage comparing to normal pregnancy (27). High ratio suggested an imbalance in the inflammatory reaction and it is assigned as a marker of severity in sepsis and inflammatory diseases (28).…”

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