The value of Neutrophil gelatinase-associated lipocalin and Neutrophil / Lymphocyte Ratio in the diagnosis of preeclampsia and its severity

Ali, Eham Amer; Hameed, Ban Hadi; Salman, Alea Farhan

doi:10.2152/jmi.68.321

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Of the fourteen studies, two were cross-sectional studies, five were cohort studies, and seven were case-control studies. 13,14,[19][20][21][22][23][24][25][26][27][28][29][30] The studies included samples of women with median age of 17.4 to 35.5 years and a range of 101 to 1481. This systematic review revealed that NLR and MEOWS had the ability to detect the incidence and severity of preeclampsia.…”

Section: Resultsmentioning

confidence: 99%

“…From these three comparisons, significant differences in NLR between the groups studied were obtained (p=0.027). 14 Furthermore, starting with a discussion of MEOWS parameters a study conducted by Singh et al (2016) found that as many as two eighty-four patients (26.60%) met the abnormal criteria after admission and the greatest morbidity due to hypertension (69.4%). 21 ) of all patients who met the maternal morbidity criteria.…”

Section: Resultsmentioning

confidence: 99%

“…The combination of two essential mechanisms in PE pathogenesis, the abnormal immune and inflammatory responses is the basis for evaluating the value of NLR as a prognostic modality to determine the severity of PE. 14 Good confectionery management including the duration of identification time can prevent the severity of obstetric complications so that the burden of maternal death and long-term complications can be prevented.…”

Section: Introductionmentioning

confidence: 99%

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The combination of NLR and MEOWS as a potential modality for detecting the severity of preeclampsia: A systematic review

Singgih,

Kwary,

Tamara

2023

MOG

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HIGHLIGHTS PE is still one of the contributors to morbidity and mortality which is quite high for pregnant women in Indonesia. The use of NLR and MEOWS modalities as predictors of preeclampsia incidence shows significant potential and can be applied especially in facilities with limited resources. ABSTRACT Objective: Describe modalities of detecting the severity of preeclampsia (PE) between neutrophil-to-lymphocyte ratio (NLR) levels and Modified Obstetric Early Warning Systems (MEOWS). Materials and Methods: We used a systematic search in PubMed, ScienceDirect, and Google Scholar for English articles, full access, published between 2015 – 2023 that evaluated modalities between NLR levels and MEOWS for detecting the severity of preeclampsia which resulted in 208 works of literature. Among the studies we found 14 works of literature that met the PICO inclusion criteria were included in this study. Results: PE is still one of the high morbidities and mortality in maternal patients. It takes tools to predict the possible risk of PE events that can occur. NLR is one of the markers that become a prognostic modality to determine the severity of PE. MEOWS is one of the tools to assess the level of care of patients who carry out the treatment. NLR and MEOWS can be modalities for predicting PE severity. Conclusion: NLR and MEOWS can be used even with limited resources. The combined use of NLR and MEOWS can be an alternative and potential modality in detecting PE severity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The combination of NLR and MEOWS as a potential modality for detecting the severity of preeclampsia: A systematic review

Singgih,

Kwary,

Tamara

2023

MOG

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Circulating neutrophil gelatinase-associated lipocalin and preeclampsia: a meta-analysis

Wei

Wang

et al. 2023

The Journal of Maternal-Fetal & Neonatal Medicine

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Serum Elabela Level as a Reliable Biomarker for Predicting of Liver Fibrosis in Iraqi Patients with Chronic Hepatitis C

Ali,

Al-Bayati,

Farhan Salman

2024

Med J Babylon

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Background: Elabela is a newly discovered peptide hormone that has been implicated in liver disease. Objective: The main objective of the current work is to assess whether variations in blood Elabela levels among chronic hepatitis C (CHC) patients from Iraq might be used as a biomarker for liver fibrosis. Materials and Methods: A case-control study was conducted in Baghdad, Iraq. The overall sample size (n = 80) that met the inclusion criteria was divided into two groups as follows: 40 patients who were diagnosed with CHC and 40 healthy matched individuals. The aspartate aminotransferase-to-platelet ratio index (APRI) was used to identify the group of patients at risk for liver fibrosis. The routine complete blood count, liver function, and serum Elabela tests were performed. Serum Elabela level was evaluated by using the enzyme-linked immunosorbent assay technique. Results: Serum Elabela was significantly higher in the CHC group (33.89 ± 8.51 ng/mL) than in the control group (18.11 ± 5.27 ng/mL). In addition, the percentage of CHC patients at a high risk of developing fibrosis was 42.5%. Also, the high-risk fibrosis group showed a significantly higher concentration of Elabela and APRI than the other groups (low-risk and control) at P < 0.0001. Alanine aminotransaminase and aspartate aminotransaminase showed a high increase while a low decrease in both Hb and platelet count against the healthy group (P < 0.0001). Conclusion: High serum Elabela level in CHC patients compared to the control group was associated with liver fibrosis and could be used clinically as a reliable biomarker to determine the high-risk patient in need of invasive liver biopsy and hazardous therapeutics.

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The value of Neutrophil gelatinase-associated lipocalin and Neutrophil / Lymphocyte Ratio in the diagnosis of preeclampsia and its severity

Cited by 4 publications

References 24 publications

The combination of NLR and MEOWS as a potential modality for detecting the severity of preeclampsia: A systematic review

The combination of NLR and MEOWS as a potential modality for detecting the severity of preeclampsia: A systematic review

Circulating neutrophil gelatinase-associated lipocalin and preeclampsia: a meta-analysis

Serum Elabela Level as a Reliable Biomarker for Predicting of Liver Fibrosis in Iraqi Patients with Chronic Hepatitis C

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