Inadequate pain relief among patients with primary knee osteoarthritis

Laires, PA; Miranda, Luís Cunha; Cernadas, Rui; Rajagopalan, Srini; Taylor, Stephanie; Silva, José C.

doi:10.1016/j.rbre.2016.11.005

Cited by 11 publications

(8 citation statements)

References 30 publications

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“…Although OA shows local inflammation, the reduced strength and muscle mass also are observed in OA patients, as well as in RA patients. Due to theses alterations, OA patients may show reduction of functionality [ 12 , 15 , 17 , 18 ], increase in risk of falls and fractures [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of resistance training with blood flow restriction on muscle strength, muscle hypertrophy and functionality in patients with osteoarthritis and rheumatoid arthritis: A systematic review with meta-analysis

et al. 2021

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Introduction Rheumatoid arthritis(RA) and osteoarthritis(OA) patients showed systemic manifestations that may lead to a reduction in muscle strength, muscle mass and, consequently, to a reduction in functionality. On the other hand, moderate intensity resistance training(MIRT) and high intensity resistance training(HIRT) are able to improve muscle strength and muscle mass in RA and OA without affecting the disease course. However, due to the articular manifestations caused by these diseases, these patients may present intolerance to MIRT or HIRT. Thus, the low intensity resistance training combined with blood flow restriction(LIRTBFR) may be a new training strategy for these populations. Objective To perform a systematic review with meta-analysis to verify the effects of LIRTBFR on muscle strength, muscle mass and functionality in RA and OA patients. Materials and methods A systematic review with meta-analysis of randomized clinical trials(RCTs), published in English, between 1957–2021, was conducted using MEDLINE(PubMed), Embase and Cochrane Library. The methodological quality was assessed using Physiotherapy Evidence Database scale. The risk of bias was assessed using RoB2.0. Mean difference(MD) or standardized mean difference(SMD) and 95% confidence intervals(CI) were pooled using a random-effects model. A P<0.05 was considered statistically significant. Results Five RCTs were included. We found no significant differences in the effects between LIRTBFR, MIRT and HIRT on muscle strength, which was assessed by tests of quadriceps strength(SMD = -0.01[-0.57, 0.54], P = 0.96; I² = 58%) and functionality measured by tests with patterns similar to walking(SMD = -0.04[-0.39, 0.31], P = 0.82; I² = 0%). Compared to HIRT, muscle mass gain after LIRTBFR was reported to be similar. When comparing LIRTBFR with low intensity resistance training without blood flow restriction(LIRT), the effect LIRTBFR was reported to be higher on muscle strength, which was evaluated by the knee extension test. Conclusion LIRTBFR appears to be a promising strategy for gains in muscle strength, muscle mass and functionality in a predominant sample of RA and OA women.

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Section: Introductionmentioning

confidence: 99%

The effects of resistance training with blood flow restriction on muscle strength, muscle hypertrophy and functionality in patients with osteoarthritis and rheumatoid arthritis: A systematic review with meta-analysis

et al. 2021

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“…13 Studies have reported dissatisfaction among NSAID users with respect to adequate pain relief. 14,15 Also, NSAIDs, while causing the known adverse effects, do not halt disease progression. 16 In this scenario, supplementation of nutrients, natural or synthetic, is a recent strategy for managing and preventing OA.…”

Section: Introductionmentioning

confidence: 99%

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Assessing Efficacy and Safety of a Novel Low-Dose Turmeric Extract Formulation in Healthy Adults with Chronic Knee Pain

Thanawala¹,

Shah²,

Venkateswarlu³

et al. 2021

CPAA

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Background: Knee pain causes functional limitations, eventually compromising the quality of life. We evaluated the efficacy of our water-dispersible turmeric formulation (60% natural curcuminoids, TurmXTRA 60N ® -WDTE60N), which exhibited better PK profile at low dose (250 mg) than standard turmeric extract, in alleviating symptoms of chronic knee pain. Methods: In this randomized, double-blind, placebo-controlled trial, subjects received either 250 mg WDTE60N capsule (150 mg curcuminoids; n = 53) or appearance-matched placebo capsule (n = 53) once daily for 90 days. Primary endpoint was change in pain score on the visual analogue scale (VAS) after 80-m fast-paced walk test. Results: A total of 96 subjects completed the study. WDTE60N reduced VAS score from baseline (5.4 ± 0.9) to day 90 (3.8 ± 0.8) with greater mean reduction than placebo (−1.5 ± 0.7 vs −0.6 ± 0.8, p < 0.0001; 2.5 times). It also significantly improved the time taken for 80m fast-paced walk test and 9-step stair-climb test; and improved all biomarkers compared to placebo (p > 0.05). Three adverse events occurred but were unrelated to study products. Conclusion: WDTE60N 250 mg administered once daily for 3 months, alleviated knee pain, improved joint function in healthy subjects with chronic knee pain, was well tolerated and safe.

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“…La alteración de todos esos tejidos, activa el sistema nociceptivo que genera dolor. [22][23][24] Debido a ese estímulo, se vierten dentro de la articulación mediadores de tipo inflamatorio como: bradicinina, histamina, prostaglandinas, ácido láctico, sustancia P y péptido C, que desde el punto de vista genético está relacionado con la calcitonina. Todos esos mediadores, disminuyen el umbral doloroso de los tejidos dentro de la articulación y hacen que los mismos sean más sensibles a la respuesta dolorosa.…”

Section: Características Generales Del Dolor En La Artrosis De Rodillaunclassified

Dolor en la Artrosis de Rodilla

López

Soto-Carrasco²,

Lorenzo

2019

Rev Chil Ortop Traumatol

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Pain is the main symptom of osteoarthritis. Determining the distinctive features of pain in knee osteoarthritis allows for an accurate diagnosis. This article gives a review of the results from research work on the typical features of knee osteoarthritic pain. The mechanics and biochemical causes of pain are described including both bone and synovial biochemical symptom-related factors. The relationships between knee pain, various imaging techniques and pain mechanism are also identified. Finally, the used pain scales are presented.

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Inadequate pain relief among patients with primary knee osteoarthritis

Abstract: Our findings indicate that improvements are needed in the management of pain in knee OA in order to achieve better outcomes in terms of pain relief, function and quality of life.

Cited by 11 publications

References 30 publications

The effects of resistance training with blood flow restriction on muscle strength, muscle hypertrophy and functionality in patients with osteoarthritis and rheumatoid arthritis: A systematic review with meta-analysis

The effects of resistance training with blood flow restriction on muscle strength, muscle hypertrophy and functionality in patients with osteoarthritis and rheumatoid arthritis: A systematic review with meta-analysis

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Assessing Efficacy and Safety of a Novel Low-Dose Turmeric Extract Formulation in Healthy Adults with Chronic Knee Pain

Dolor en la Artrosis de Rodilla

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