Schinus terebinthifolius administration prevented behavioral and biochemical alterations in a rotenone model of Parkinson's disease

Schinus terebinthifoliusEssential Oil Attenuates Scopolamine-Induced Memory Deficits via Cholinergic Modulation and Antioxidant Properties in a Zebrafish Model

“…Also, the treatment with scopolamine promoted decreased locomotion tracking plots that were prevented by STF treatment nearly to the donepezil group. Our results suggested that Schinus terebinthifolius essential oil possesses anxiolytic and memory supporting profile, which is in agreement with the literature where Schinus terebinthifolius administration exhibited the neuroprotective effects possibly mediated by its antioxidant activity in a rotenone rat model of Parkinson's disease [7]. In addition, the improvement of memory deficits as a result of STF administration could be attributed to not only the presence in high amounts of the active compounds such as β -phellandrene, α -pinene, terpinen-4-ol, and α -phellandrene but also to the presence of other components in small amounts but with high activity such as β -pinene, followed by dl-limonene, γ -terpinene, α -terpineol, and α -terpinene or synergy between them.…”

“…In recent years, the anti-Alzheimer's potential for natural products from medicinal plants has been recognized by the scientific community [7, 8]. Hence, a great deal of research studies focus recently on plants and other natural products used around the world for age-related central nervous system (CNS) diseases [9].…”

Phenolic Compounds Present Schinus terebinthifolius Raddi Influence the Lowering of Blood Pressure in Rats

“…Treatment with G5 produced hypolocomotion, increased immobility and muscular incoordination, with activity mainly observed on the central nervous system of the mice. These findings contradict previous studies reporting that the extract from the S. terebinthifolius stem bark alleviated the effects of rat motor incoordination caused by the administration of rotenone in the rotarod test [ 15 ], and that mangiferin isolated from the bark of Mangifera indica L. (Anacardiaceae) did not produce any significant effect on motor coordination in rotarod in rats indicating that the observed antinociception was not related to sedation or motor anomaly, but to the peripheral antinociceptive activity [ 35 ].…”

“…Other researchers have identified gallic acid in leaves and stem bark of S. terebinthifolius [ 14 , 15 ], but there are no reports on the presence of naringenin flavanone in this species. The presence of I30′,II8-binaringenin in S. terebinthifolius was confirmed and allocated to the internal part of the fruit [ 16 ].…”

“…The brain is highly susceptible to free radical damage due to its high rate of oxygen utilization and the relatively low presence of antioxidant enzymes and free radical scavengers. There is growing interest in the establishment of therapeutic and dietary strategies to combat oxidative stress induced by damage mainly to the central nervous system [ 15 ]. Oxidative stress is a result of an imbalance between free radicals and may be ameliorated by the endogenous action of antioxidant defense systems [ 21 ].…”