Evaluation of anti-inflammatory, immunomodulatory, chemopreventive and wound healing potentials from Schinus terebinthifolius methanolic extract

Fedel-Miyasato, Lis E.S.; Kassuya, Cândida Aparecida Leite; Auharek, Sarah Alves; Formagio, Anelise Samara Nazari; Cardoso, Cláudia Andréa Lima; Mauro, M O; Cunha-Laura, Andréa Luiza; Monreal, Antônio Carlos Duenhas; Vieira, M.C.; Oliveira, Rodrigo Juliano

doi:10.1016/j.bjp.2014.08.004

Cited by 26 publications

(8 citation statements)

References 29 publications

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“…Prolonged inflammation can be detrimental to wound healing, because it may cause new tissue damage and delays the proliferation of skin cells. Therefore, reduced leukocyte migration and plasma leakage after luteolin treatment 51 might be beneficial after the initial immune response in wounds. In the proliferative phase, angiogenesis is one of the key steps to achieve an efficient wound healing response.…”

Section: Wound Healingmentioning

confidence: 99%

Luteolin as a modulator of skin aging and inflammation

et al. 2020

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Luteolin belongs to the group of flavonoids and can be found in flowers, herbs, vegetables and spices. It plays an important role in defending plants, for example against UV radiation by partially absorbing UVA and UVB radiation. Thus, luteolin can also decrease adverse photobiological effects in the skin by acting as a first line of defense. Furthermore, anti-oxidative and anti-inflammatory activities of luteolin were described on keratinocytes and fibroblasts as well as on several immune cells (e.g., macrophages, mast cell, neutrophils, dendritic cells and T cells). Luteolin can suppress proinflammatory mediators (e.g., IL-1β, IL-6, IL-8, IL-17, IL-22, TNF-α and COX-2) and regulate various signaling pathway (e.g., the NF-κB, JAK-STAT as well as TLR signaling pathway). In this way, luteolin modulates many inflammatory processes of the skin. The present review summarizes the recent in vitro and in vivo research on luteolin in the field of skin aging and skin cancer, wound healing as well as inflammatory skin diseases, including psoriasis, contact dermatitis and atopic dermatitis.In conclusion, luteolin might be a promising molecule for the development of topic formulations and systemic agents against inflammatory skin diseases.

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Section: Wound Healingmentioning

confidence: 99%

Luteolin as a modulator of skin aging and inflammation

et al. 2020

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“…Tabaldi et al (2016) found a value lower than that of our work for total flavonoids in the methanolic extract from Aroeira leaves: 111.81 mg of quercetin equivalent (QE)/g extract [ 23 ]. Fedel-Miyasato et al (2014) studied the same type of extract and reported a much higher value: 460.20 mg QE/g [ 24 ]. This value is higher than that found by Uliana et al (2016) for ethanolic extract from leaves of S. terebinthifolius : 69.67 mg QE/g of macerated extract and 243.09 mg QE/g of extract obtained with the use of assisted ultrasound technique [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

Phenolic Compounds Present Schinus terebinthifolius Raddi Influence the Lowering of Blood Pressure in Rats

et al. 2017

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This study identified two phenolic compounds in Schinus terebinthifolius Raddi fruits: naringenin (first report in this species) and gallic acid. Their structures were elucidated by nuclear magnetic resonance (NMR) data (1H-, 13C-NMR) and a high-performance liquid chromatography (HPLC) technique. A high content of phenolics (659.21 mg of gallic acid equivalents/g of sample—Folin-Ciocalteau method) and total flavonoids (140.69 mg of rutin equivalents/g of sample—aluminum chloride method) were quantified in S. terebinthifolius, as well as high antioxidant activity (77.47%—2,2-diphenyl-1-picrylhydrazyl, DPPH method). The antihypertensive activity related to its phenolic content was investigated. After intravenous infusion in Wistar rats, these phenolics significantly reduced (p < 0.05) the systolic, median, and diastolic arterial pressures of individuals. The rotarod test was performed to determine the mechanism of action of the sample vasorelaxant effect. It was found that its action exceeded that of the positive control used (diazepam). This confirmed the vasodilatory activity exerted by S. terebinthifolius fruits is related to the phenolic compounds present in the plant, which are potent antioxidants and inhibit oxidative stress, mainly in the central nervous system.

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“…However, spleen phagocytic activity is increased without an increase in the number of cells with DNA damage when the oils were administered, since the oils do not exhibit toxicogenetic activity (neither genotoxicity nor mutagenicity). This finding suggests that the increase in spleen phagocytic activity might be mediated by immunomodulating mechanisms, rather than only being a response to genotoxic and mutagenic damage leading to an increase of the number of active macrophages in the spleen (Ishii et al, 2011;Fedel-Miyasato et al, 2014b;Gonçalves et al, 2014). When cyclophosphamide was combined with the oils using various doses and protocols, the levels of spleen phagocytic activity were intermediate between the levels exhibited by the groups treated with the oils alone and the group treated only with cyclophosphamide.…”

Section: Discussionmentioning

confidence: 96%

Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide

Magosso¹,

Carvalho

Shneider³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Acrocomia aculeata is a plant rich in antioxidant compounds. Studies suggest that this plant has anti-inflammatory, antidiabetic, and diuretic potential. We assessed the antigenotoxic, antimutagenic, immunomodulation, and apoptotic potentials of A. aculeata alone and in combination with an antitumor agent, cyclophosphamide. Swiss male mice (N = 140) were used. The animals were divided into 14 experimental groups as follows: a negative group, a positive group (100 mg/kg cyclophosphamide), groups that only received the oil extracted from the almond (AO) and from the pulp (PO) of A. aculeata at doses of 3, 15, and 30 mg/kg, and the associated treatment groups (oils combined with cyclophosphamide) involving pretreatment, simultaneous, and post-treatment protocols. Data suggest that both oils were chemopreventive at all doses, based on the tested protocols. The highest damage reduction percentages, observed for AO and PO were 88.19 and 90.03%, respectively, for the comet assay and 69.73 and 70.93%, respectively, for the micronucleus assay. Both AO and PO demonstrated immunomodulatory activity. The oils reduced the capacity of cyclophosphamide to trigger apoptosis in the liver, spleen, and kidney cells. These results suggest that A. aculeate AO and PO can be classified as a functional food and also enrich other functional foods and nutraceuticals with chemopreventive features. However, they are not appropriate sources for chemotherapeutic adjuvants, in particular for those used in combination with cyclophosphamide.

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Evaluation of anti-inflammatory, immunomodulatory, chemopreventive and wound healing potentials from Schinus terebinthifolius methanolic extract

Cited by 26 publications

References 29 publications

Luteolin as a modulator of skin aging and inflammation

Luteolin as a modulator of skin aging and inflammation

Phenolic Compounds Present Schinus terebinthifolius Raddi Influence the Lowering of Blood Pressure in Rats

Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide

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