Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide

Abstract

ABSTRACT. Acrocomia aculeata is a plant rich in antioxidant compounds. Studies suggest that this plant has anti-inflammatory, antidiabetic, and diuretic potential. We assessed the antigenotoxic, antimutagenic, immunomodulation, and apoptotic potentials of A. aculeata alone and in combination with an antitumor agent, cyclophosphamide. Swiss male mice (N = 140) were used. The animals were divided into 14 experimental groups as follows: a negative group, a positive group (100 mg/kg cyclophosphamide), groups that only received the oil extracted from the almond (AO) and from the pulp (PO) of A. aculeata at doses of 3, 15, and 30 mg/kg, and the associated treatment groups (oils combined with cyclophosphamide) involving pretreatment, simultaneous, and post-treatment protocols. Data suggest that both oils were chemopreventive at all doses, based on the tested protocols. The highest damage reduction percentages, observed for AO and PO were 88.19 and 90.03%, respectively, for the comet assay and 69.73 and 70.93%, respectively, for the micronucleus assay. Both AO and PO demonstrated immunomodulatory activity. The oils reduced the capacity of cyclophosphamide to trigger apoptosis in the liver, spleen, and kidney cells. These results suggest that A. aculeate AO and PO can be classified as a functional food and also enrich other functional foods and nutraceuticals with chemopreventive features. However, they are not appropriate sources for chemotherapeutic adjuvants, in particular for those used in combination with cyclophosphamide.

Prevention of DNA damage and anticarcinogenic activity of Activia^® in a preclinical model

“…In a systematic analysis, biometric parameters do not indicate excessive weight loss that would correlate to toxicity (Magosso et al, 2016). Also, no changes were observed in the behavior or in variations in feed intake or water.…”

Acrocomia aculeataoil: Beneficial effects on cyclophosphamide-induced reproductive toxicity in male rats

“…In a recent study, Magosso et al. () reported that A. aculeata prevented toxicogenetic damage caused by CP in mice. However, it is necessary to do more investigation about this fruit before its incorporation as an oil source and functional food, as little pharmacological information is known about this species.…”

Effect of Nicotine on CYP2B1 Expression in a Glioma Animal Model and Analysis of CYP2B6 Expression in Pediatric Gliomas

“…Several side effects have been associated to CPA use such as nephrotoxicity, gonadotoxicity, and possible cardiotoxic effects. In order to reduce CPA toxicity, different chemotherapy schemes and strategies have been proposed, as well as adjuvants [ 16 , 17 , 25 ]. Among these strategies, the sensitization of cancer cells to CPA antitumor effect by increasing the expression of enzymes related to its activation [ 7 , 8 , 9 , 15 ] has been addressed.…”