AIM2 inflammasome activation may mediate high mobility group box 1 release in murine allergic rhinitis

Wang, Yan; Chen, Shan; Yang, Pingli; Chen, Jianjun; Kong, Weijia; Wang, Yanjun

doi:10.1016/j.bjorl.2020.12.014

Cited by 3 publications

(2 citation statements)

References 39 publications

(32 reference statements)

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“…On the other hand, it was estimated that 48%-74% of the population is affected by heat waves all the world. Therefore, identifying the AR risk factors is important (13,14).…”

Section: Discussionmentioning

confidence: 99%

Study effect of weather conditions on the allegro-inflammatory factors and clinical symptoms of allergic rhinitis

Yonghua

Nasab

Liuo

2022

Preprint

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Purpose: Allergic rhinitis (AR) is one of the allergic diseases that initiated by T helper lymphocyte (Th)2 immune response and mediators are main reason of clinical symptoms. In the genetically predisposed AR patients, environmental factors are main triggers of allergic reactions. Therefore, effects of climate conditions (warm, cold, humid and dry) on allergic rhinitis were evaluated.Methods: AR model was produced in mice under the four different conditions. Then, Clinical symptoms (sneezing and nasal rubbing), total immunoglobulin (Ig)E, histamine, interleukin (IL)-4 leukotriene (LT)B4, LTC4 levels and gene expression of CysLT1R, HRH1, and MUC5a were studied.Results: Nasal rubbing, histamine level, expression of MUC5a and HRH1 genes in the AR-C, sneezing in the AR-D, LTB4 and LTC4 levels and expression of CysLT1R gene in the AR-W groups were significantly (P<0.05) increased compared to the AR group. The levels of total IgE and IL-4 had no significant changes (P>0.05). Conclusions: Air temperature and humidity had effect on AR pathophysiology and, weather conditions can be an important factor in control of AR.

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“…On the other hand, it was estimated that 48%-74% of the population is affected by heat waves all the world. Therefore, identifying the AR risk factors is important (13,14).…”

Section: Discussionmentioning

confidence: 99%

Study effect of weather conditions on the allegro-inflammatory factors and clinical symptoms of allergic rhinitis

Yonghua

Nasab

Liuo

2022

Preprint

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“…Moreover, NLRC4 was also found to be up-regulated in neutrophilic asthma, 133 and Wang et al reported that AIM2 inflammasome was activation in murine allergic rhinitis (AR) and might mediate HMGB1 release. 134 What’s more, honey bee venom could induce AIM2 inflammasome activation in human keratinocytes, which might promote subsequent allergic responses. 135 Therefore, targeting the activation of these inflammasomes helps to reduce the inflammatory response, thereby reducing the damage caused by allergies.…”

Section: The Roles Of Ncrnas In Inflammasomes Activation In Inflammatory Diseasesmentioning

confidence: 99%

Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases

Wang¹,

Yang²,

Yang³

et al. 2021

JIR

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Emerging data indicates that non-coding RNAs (ncRNAs) represent more than just “junk sequences” of the genome and have been found to be involved in multiple diseases by regulating various biological process, including the activation of inflammasomes. As an important aspect of innate immunity, inflammasomes are large immune multiprotein complexes that tightly regulate the production of pro-inflammatory cytokines and mediate pyroptosis; the activation of the inflammasomes is a vital biological process in inflammatory diseases. Recent studies have emphasized the function of ncRNAs in the fine control of inflammasomes activation either by directly targeting components of the inflammasomes or by controlling the activity of various factors that control the activation of inflammasomes; consequently, ncRNAs may represent potential therapeutic targets for inflammatory diseases. Understanding the precise role of ncRNAs in controlling the activation of inflammasomes will help us to design targeted therapies for multiple inflammatory diseases. In this review, we summarize the regulatory role and therapeutic potential of ncRNAs in the activation of inflammasomes by focusing on a range of inflammatory diseases, including microbial infection, sterile inflammatory diseases, and fibrosis-related diseases. Our goal is to provide new ideas and perspectives for future research.

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Understanding the role of NLRP3-mediated pyroptosis in allergic rhinitis: A review

Cheng

Wang

2023

Biomedicine & Pharmacotherapy

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AIM2 inflammasome activation may mediate high mobility group box 1 release in murine allergic rhinitis

Cited by 3 publications

References 39 publications

Study effect of weather conditions on the allegro-inflammatory factors and clinical symptoms of allergic rhinitis

Study effect of weather conditions on the allegro-inflammatory factors and clinical symptoms of allergic rhinitis

Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases

Understanding the role of NLRP3-mediated pyroptosis in allergic rhinitis: A review

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