Study effect of weather conditions on the allegro-inflammatory factors and clinical symptoms of allergic rhinitis

Abstract

Purpose: Allergic rhinitis (AR) is one of the allergic diseases that initiated by T helper lymphocyte (Th)2 immune response and mediators are main reason of clinical symptoms. In the genetically predisposed AR patients, environmental factors are main triggers of allergic reactions. Therefore, effects of climate conditions (warm, cold, humid and dry) on allergic rhinitis were evaluated.Methods: AR model was produced in mice under the four different conditions. Then, Clinical symptoms (sneezing and nasal rubbing), total immunoglobulin (Ig)E, histamine, interleukin (IL)-4 leukotriene (LT)B4, LTC4 levels and gene expression of CysLT1R, HRH1, and MUC5a were studied.Results: Nasal rubbing, histamine level, expression of MUC5a and HRH1 genes in the AR-C, sneezing in the AR-D, LTB4 and LTC4 levels and expression of CysLT1R gene in the AR-W groups were significantly (P<0.05) increased compared to the AR group. The levels of total IgE and IL-4 had no significant changes (P>0.05). Conclusions: Air temperature and humidity had effect on AR pathophysiology and, weather conditions can be an important factor in control of AR.