Study of the relationship between human MIF level, MIF-794CATT5-8 microsatellite polymorphism, and susceptibility of tuberculosis in Southwest China

Li, Yanlin; Zeng, Zhaofang; Deng, Shaoli

doi:10.1016/j.bjid.2012.06.018

Cited by 17 publications

(14 citation statements)

References 11 publications

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“…Additionally, they suggested that the circulating MIF values significantly correlated with serum interferon-γ, which is one of the most important cytokines contributing to protective immunity against Mtb 12 . Similar results were found by Li and co-colleagues in a Chinese population 24 . Fortunately, our meta-analysis results were consistent with the previous consequences, suggesting that MIF may played a crucial role in immune responses to individual infection with Mtb .…”

Section: Discussionsupporting

confidence: 90%

“…Finally, 11 eligible articles 12, 18–27 were included in the current meta-analysis. Nine of the 11 included articles were in English 12, 18–24, 27 and two were in Chinese 25, 26 . Among the studies, seven articles 12, 19, 23–27 were conducted in Asian populations, three studies 18, 20, 21 were conducted in Caucasians and one study 22 was conducted in Africans.…”

Section: Resultsmentioning

confidence: 99%

“…The included subjects in the four studies were free of HIV 12, 18, 20, 26 , whereas the comorbidity (HIV) was not addressed in another six studies 19, 21, 23–25, 27 . Additionally, three articles were of moderate quality (score = 6) 24, 26, 27 , and the other included studies were of high quality according to the Newcastle-Ottawa Scale quality score evaluation (see Methods) 12, 18–23, 25 . The characteristics of the collected studies are listed in Tables 1 and 2.

Figure 1The flow diagram of the included and excluded studies. …”

Section: Resultsmentioning

confidence: 99%

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Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis

Xiang

Yan

Qin

et al. 2017

Sci Rep

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Many studies have indicated that Macrophage migration inhibitory factor (MIF)-173G/C gene polymorphisms are associated with susceptibility to pulmonary tuberculosis (PTB). Additionally, some studies have suggested that there are higher levels of serum MIF in patients with PTB than the controls. However, the results of these studies were underpowered. The current study aimed to precisely evaluate the association between the MIF-173G/C polymorphism and serum MIF concentrations with PTB. Therefore, a systematic literature search was preformed to identify studies involving the indicated association. Eleven articles (1316 cases and 1272 controls) were included in the study. The results indicated that the MIF-173G/C polymorphism was significantly associated with PTB susceptibility, especially in Asians. Interestingly, the results further detected that circulating MIF levels were significantly higher in patients with PTB than in healthy controls, but this was only the case among Asians. Moreover, the statistical significance was also similar to that of the high quality group. The present study indicated that the MIF-173G/C polymorphism may contribute to the development of PTB. Furthermore, significantly higher serum MIF levels were observed in PTB patients than in controls, which further indicated that the MIF may play an important role in PTB progression, particularly in Asians.

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Section: Discussionsupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Figure 1The flow diagram of the included and excluded studies. …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis

Xiang

Yan

Qin

et al. 2017

Sci Rep

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“…Polymorphism of MIF on the −173 position has been reported in several inflammatory diseases, including ulcerative colitis (UC) [10], psoriasis [9] and tuberculosis (TB) [11]. Several studies have reported the association between MIF794CATT gene polymorphism, MIF protein level and CAD.…”

Section: Discussionmentioning

confidence: 99%

“…Loci rs2096525 and rs2070766 are located in introns, whereas rs755622 and −794CATT5–8 are located in the promoter region of MIF [9] . Earlier studies have found that circulating MIF levels are elevated in ulcerative colitis (UC) [10], psoriasis [9] and tuberculosis (TB) [11]. Since these diseases are accompanied by persistent inflammation of varying degrees, it is possible that MIF may play a role in the development of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Macrophage migration inhibitory factor promoter polymorphisms (−794 CATT5–8): Relationship with soluble MIF levels in coronary atherosclerotic disease subjects

Qian

Wang

Thapa

et al. 2017

BMC Cardiovasc Disord

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BackgroundWe analyzed the relationship of −794 CATT5–8 MIF polymorphisms with soluble MIF in Coronary Atherosclerotic Disease (CAD) patients.MethodsA total of 256 patients selected, on which 186 normal-coronary and 70 Coronary artery disease subjects, were recruited in the study (Retrospectively registered). Genotyping of −794 CATT5–8 polymorphisms were performed by PCR and DNA sequencing. Serum MIF levels were measured using an ELISA kit. Patients were classified by coronary angiogram, and CAD based on Gensini’s integral degree (angiographic scoring system).ResultsThe allele frequency and genotype frequency of −794 CATT5–8 did not show any differences in normal-coronary subjects and CAD subjects. In CAD patients, serum MIF levels was lower in CATT (5) subjects than in CATT (7) subjects, while the genotype of −794 CATT5–8 did not show differences in serum MIF levels. In addition, we found a decrease in serum MIF levels in carriers of the (5/5) genotypes the −794 CATT5–8 MIF polymorphisms, although it was not significant. There was no relationship of CAD class and the allele frequency of −794 CATT5–8.ConclusionsThis study found no association between CAD class and −794 CATT5–8 MIF polymorphisms with soluble MIF levels in CAD Subjects.Trial registrationNCT01750502 (November 2012, Retrospectively registered).

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Macrophage migration inhibitory factor − 794 CATT5−8 microsatellite polymorphism and susceptibility of tuberculosis

et al. 2021

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Study of the relationship between human MIF level, MIF-794CATT5-8 microsatellite polymorphism, and susceptibility of tuberculosis in Southwest China

Abstract: The appearance of MIF-794CATT 7/7 and 7/8 is associated with susceptibility to TB, and may play an important role in the occurrence and development of TB in Southwest China.

Cited by 17 publications

References 11 publications

Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis

Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis

Macrophage migration inhibitory factor promoter polymorphisms (−794 CATT5–8): Relationship with soluble MIF levels in coronary atherosclerotic disease subjects

Macrophage migration inhibitory factor − 794 CATT5−8 microsatellite polymorphism and susceptibility of tuberculosis

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