Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis

Xiang, Tong; Yan, Zhipeng; Qin, Zhou; Liu, Sitong; Han, Jing; Ma, Yao; Yang, Xue; Fan, Hong

doi:10.1038/s41598-017-00299-1

Cited by 11 publications

(9 citation statements)

References 35 publications

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“…In addition, Xiang et al have found that the level of MIF plasma in Asian patients with pulmonary TB was significantly higher than that in the control group, but there was no significant difference among Africans. [ 15 ] We also showed that the GG genotype may be associated with a higher serum concentration of MIF in spinal TB patients. Based on a review of the correlation between the expression of mRNA transcription and protein levels in many cases is not good.…”

Section: Discussionmentioning

confidence: 68%

“…[ 13 , 14 ] In fact, some researchers have found that MIF-173G/C polymorphism may be involved in the development of pulmonary TB in Asians and Caucasians and the frequency of MIF-173CC homozygote and C allele in pulmonary TB group are significantly higher than that in healthy control group. [ 15 ] Liu et al have found that the frequency of MIF-173CC homozygote and C allele in pulmonary TB group in Southwest China were significantly higher than that in healthy control group. Similarly, according to our data, the MIF C minor allele and MIF C carriers are more frequent in spinal TB patients than controls.…”

Section: Discussionmentioning

confidence: 99%

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Migration inhibitory factor in spinal tuberculosis: -173G/C polymorphisms, and transcript and protein levels in a northern province of China

Wang

Sheng

et al. 2020

Medicine

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The aim of this study was to elucidate the possible association between migration inhibitory factor (MIF)-173G/C gene polymorphisms and transcript and plasma levels of MIF in spinal tuberculosis (TB) patients. Clinical data were collected from 254 spinal TB patients and 262 healthy controls participating in the study. The genotype of the MIF-173G/C gene was amplified by polymerase chain reaction and genotyped by DNA sequencing technology. The level of mRNA expression was determined by real-time polymerase chain reaction and MIF plasma levels were measured by a solid-phase enzyme-linked immunosorbent assay. The frequency of the C allele and GC+CC genotype in MIF-173G/C was over-represented in spinal TB patients. The mean MIF mRNA level in spinal TB patients and patients with the GG and GC+CC genotype were significantly lower than controls; however, our study also indicated that the MIF concentration in spinal TB patients and patients with the GG and GC+CC genotypes were significantly higher than controls. Spinal TB patients with the GG genotype had higher MIF plasma levels than patients with the GC+CC genotype. The C-reactive protein level and erythrocyte sedimentation rate was correlated with the MIF plasma level. In summary, the association between the MIF-173G/C genetic polymorphism, reduced transcript and increased plasma levels of MIF in spinal TB patients, and MIF may play an important role in the occurrence, development, and damage of spinal TB in the northern Province population of China.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Migration inhibitory factor in spinal tuberculosis: -173G/C polymorphisms, and transcript and protein levels in a northern province of China

Wang

Sheng

et al. 2020

Medicine

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“…Another genetic variant, a −794 (rs5844572) CATT 5–8 microsatellite not yet investigated in Moroccan population, was identified to be associated with TB in Chinese population (Kuai et al., ; Li et al., ; Tong et al., ; Wang et al., ).…”

Section: Candidate Genes and The Risk Of Developing Tbmentioning

confidence: 99%

“…lite not yet investigated in Moroccan population, was identified to be associated with TB in Chinese population (Kuai et al, 2016;Tong et al, 2017;Wang et al, 2016).…”

Section: Macrophage Migration Inhibitory Factor (Mif)mentioning

confidence: 99%

Current immunogenetic predisposition to tuberculosis in the Moroccan population

Qrafli

Najimi

Elaouad

et al. 2017

Int J Immunogenetics

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Tuberculosis (TB) is a serious infectious disease that kills approximately two million people per year, particularly in low- and middle-income countries. Numerous genetic epidemiology studies have been conducted of many ethnic groups worldwide and have highlighted the critical impact of the genetic environment on TB distribution. Many candidate genes associated with resistance or susceptibility to TB have been identified. In Morocco, where TB is still a major public health problem, various observations of clinical, microbiological and incidence distribution are heavily affected by genetic background and external environment. Morocco has almost the same clinical profile as do other North African countries, mainly the increase in more extrapulmonary than pulmonary forms of the diseases, when compared to European, Asian or American populations. In addition, a linkage analysis study that examined Moroccan TB patients identified a unique chromosome region that had a strong association with the risk of contracting TB. Other genes in the Moroccan population that were found to be associated seem to be involved predominantly in modulating the innate immunity. In this review, we appraise the major candidate genes that have been reported in Moroccan immunogenetic studies and discuss their updated role in TB, particularly during the first phase of the immune response to Mycobacterium tuberculosis (Mtb) infection.

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“…So far, a single-nucleotide polymorphism in the 50 regions of the MIF gene, MIF-173G/C, a G to C transversion within the MIF promoter region at position -173 creates an AP4 transcription factor binding site [5,6]. Previous studies have shown that MIF-173G/C polymorphism was related to the susceptibility of cancer [7], tuberculosis [8], and coronary atherosclerosis [9]. Recently, many studies have indicated that MIF-173G/C is associated with the pathogenesis and progression of autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

The Role of MIF-173G/C Gene Polymorphism in the Susceptibility of Autoimmune Diseases

Song

et al. 2020

Mediators of Inflammation

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Some certain genetic polymorphisms have been considered to implicate in the pathogenesis and progression of autoimmune diseases and may predispose to an early stage of general autoimmune susceptibility. Recent studies have been conducted to investigate the association between macrophage migration inhibitory factor- (MIF-) 173G/C gene polymorphism and autoimmune diseases; however, the results were not exactly identical. In the present study, a systematic review and meta-analysis of case-control studies was performed to estimate the relationship. A comprehensive search of PubMed, Ebsco, EMbase, WanFang databases and CNKI was done. Odds ratio (ORs) and corresponding 95% confidence intervals (CIs) were combined to pool the effect size. The publication bias was examined by Begg’s funnel plots and Egger’s test. RevMan 5.3 and STATA 12.0 software were used for statistical processing. 23 papers were included, and the results revealed that MIF-173G/C was significantly associated with an increased risk of autoimmune diseases in five genetic models (recessive genetic model: OR=1.95, 95% CI: 1.52-2.50; dominant genetic model: OR=1.35, 95% CI: 1.24-1.46; allele model: OR=1.32, 95% CI: 1.23-1.41; homozygote model: OR=1.92, 95% CI: 1.57-2.35; heterozygote model: OR=4.92, 95% CI: 4.03-6.02), whether in Asia, Europe, or North America. Furthermore, subgroup analysis showed an increasing risk in rheumatoid arthritis (RA), ulcerative colitis (UC), Crohn’s disease (CD), atopic dermatitis (AD), Henoch-Schonlein purpura (HSP), and Henoch-Schonlein purpura nephritis (HSPN), but it was not related to the susceptibility of autoimmune hepatitis (AIH). Therefore, it could be considered that MIF-173G/C polymorphism could increase the susceptibility of autoimmune diseases, while there may be the discrepancy of disease entity.

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Association between the MIF-173G/C Polymorphism and Serum MIF levels with Pulmonary Tuberculosis: A Meta-analysis

Cited by 11 publications

References 35 publications

Migration inhibitory factor in spinal tuberculosis: -173G/C polymorphisms, and transcript and protein levels in a northern province of China

Migration inhibitory factor in spinal tuberculosis: -173G/C polymorphisms, and transcript and protein levels in a northern province of China

Current immunogenetic predisposition to tuberculosis in the Moroccan population

The Role of MIF-173G/C Gene Polymorphism in the Susceptibility of Autoimmune Diseases

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