Macrophage migration inhibitory factor − 794 CATT5−8 microsatellite polymorphism and susceptibility of tuberculosis

Machado, Felipe Dominguez; Gehlen, Mirela; Caron, Vitória Schmidt; Mousquer, Gabriel Tassi; Bello, Graziele Lima; Anton, Camila; Bernardi, R; Freitas, Alana Ambos; Unis, Gisela; Costa, Elis Regina Dalla; Rossetti, Maria Lúcia Rosa; Silva, Denise Rossato

doi:10.1007/s15010-020-01562-w

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…In the human genome, the MIF gene is located on human chromosome 22q11.2. Two polymorphisms of this gene have been found to have associations with different diseases in humans [17,[30][31][32][33]. From an evolutionary perspective, the MIF protein represents an ancient molecule with homologs in different prokaryotes, such as bacterial cells, as well as in eukaryotes, such as amphibians, helminths, and nematodes [34].…”

Section: Sepsis Is a Life-threatening Complication Of An Infection Th...mentioning

confidence: 99%

The Role of Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (D-DT/MIF-2) in Infections: A Clinical Perspective

Breidung,

Megas,

Freytag

et al. 2023

Biomedicines

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Macrophage migration inhibitory factor (MIF) and its homolog, D-dopachrome tautomerase (D-DT), are cytokines that play critical roles in the immune response to various infectious diseases. This review provides an overview of the complex involvement of MIF and D-DT in bacterial, viral, fungal, and parasitic infections. The role of MIF in different types of infections is controversial, as it has either a protective function or a host damage-enhancing function depending on the pathogen. Depending on the specific role of MIF, different therapeutic options for MIF-targeting drugs arise. Human MIF-neutralizing antibodies, anti-parasite MIF antibodies, small molecule MIF inhibitors or MIF-blocking peptides, as well as the administration of exogenous MIF or MIF activity-augmenting small molecules have potential therapeutic applications and need to be further explored in the future. In addition, MIF has been shown to be a potential biomarker and therapeutic target in sepsis. Further research is needed to unravel the complexity of MIF and D-DT in infectious diseases and to develop personalized therapeutic approaches targeting these cytokines. Overall, a comprehensive understanding of the role of MIF and D-DT in infections could lead to new strategies for the diagnosis, treatment, and management of infectious diseases.

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Section: Sepsis Is a Life-threatening Complication Of An Infection Th...mentioning

confidence: 99%

The Role of Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (D-DT/MIF-2) in Infections: A Clinical Perspective

Breidung,

Megas,

Freytag

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

Impact of Macrophage Migration Inhibitory Factor Gene Polymorphisms and Serum Macrophage Migration Inhibitory Factor Levels on Pulmonary and Spinal Tuberculosis Susceptibility: A Pooled Analysis

Shuying

Zeng

et al. 2022

Genetic Testing and Molecular Biomarkers

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Macrophage migration inhibitory factor − 794 CATT5−8 microsatellite polymorphism and susceptibility of tuberculosis

Cited by 2 publications

References 34 publications

The Role of Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (D-DT/MIF-2) in Infections: A Clinical Perspective

The Role of Macrophage Migration Inhibitory Factor (MIF) and D-Dopachrome Tautomerase (D-DT/MIF-2) in Infections: A Clinical Perspective

Impact of Macrophage Migration Inhibitory Factor Gene Polymorphisms and Serum Macrophage Migration Inhibitory Factor Levels on Pulmonary and Spinal Tuberculosis Susceptibility: A Pooled Analysis

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