Endemic transmission of HTLV-2 in blood donors from São Luís do Maranhão, northeastern Brazil: report of two asymptomatic individuals

Viana, Graça Maria de Castro; Silva, Marcos Antônio Custódio Neto da; Souza, Victor Lima; Lopes, Natália Barbosa da Silva; Nascimento, Maria do Desterro Soares Brandão

doi:10.1016/j.bjhh.2014.11.003

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Only the presence of HTLV-1 was detected in the present study. Previous research performed in pregnant women [26] and blood donors in Maranhão [40] also detected the presence of HTLV-1 and HTLV-2, indicating that HTLV-2 is disseminated in the Maranhão population. It is of fundamental importance to know which type of HTLV is involved in the infection because HTLV-1 is the most pathogenic and is related to severe diseases, such as ATLL and HAM/TSP [2].…”

Section: Discussionmentioning

confidence: 73%

Molecular detection of human T cell lymphotropic virus type 1 in pregnant women from Maranhão state, Brazil

et al. 2020

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The human T cell lymphotropic virus (HTLV) has a worldwide distribution. HTLV is endemic in some states in the northeastern region of Brazil. This study investigated the prevalence of HTLV-1/2 in 713 pregnant women attended at the Central Laboratory of Public Health of Maranhão (LACEN-MA) between February 2015 and May 2017. Serological screening was performed by chemiluminescent microparticle immunoassay (CMIA), and reactive sera were subsequently confirmed by Western blot (WB) analysis. Five samples were determined to be HTLV-1/2-reactive by CMIA analysis, while in the WB analysis, three sera were positive for HTLV-1, and two were indeterminate. The polymerase chain reaction (PCR) analysis used to detect HTLV-1 proviral DNA showed a specific 336 base pair fragment for HTLV-1 in all CMIA-reactive serum samples. PCR products were purified and sequenced. We observed a 0.7% molecular prevalence of HTLV-1 infection. The average age of the HTLV-1-positive pregnant women was 25.6 ± 8.2 years, and the average age of the HTLV-1-negative pregnant women was 24.3 ± 6.2 (p = 0.60). We observed that there was no association of HTLV-1 infection with age, ethnicity, marital status, educational level, family income, age of first sexual intercourse, previous pregnancy, breastfeeding, intravenous drug use by partner, history of blood transfusions, or use of condoms. The prevalence of HTLV-1 observed in pregnant women demonstrated the need to implement public health policies for the screening of HTLV-1/2 in prenatal care and counseling to avoid breastfeeding by infected women; this approach could control vertical transmission and reduce the spread of this virus in the population.

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Section: Discussionmentioning

confidence: 73%

Molecular detection of human T cell lymphotropic virus type 1 in pregnant women from Maranhão state, Brazil

et al. 2020

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“…The infection is associated with several pathologies which course with a series of symptoms, although most infected individuals remain asymptomatic. The best-known diseases, as previously mentioned, are ATL and HAM/TSP because of its severe and devastating features; however, other manifestations may be present, such as ophthalmologic, dermatological, rheumatic and musculoskeletal, which usually are accompanied by sensory-motor dysfunctions, such as neuropathic pain and or nociceptive, paresis, paralysis and paresthesia (Waldman, 2004;Kanaggi, 2004;castro-Viana, 2014). All these disorders, depending on its scope, may compromise strongly the functional capacity and quality of live of individuals living with HTLV.…”

Section: Comentários Finaismentioning

confidence: 99%