1,3-Dipolar cycloaddition of azomethine ylide from Phtaloylimidophenylalanyl-2-hydroxymethylaziridine

Abstract

Phtaloylimidophenylalanyl-2-hydroxymethylaziridine has been used as a starting material to yield azomethine ylide through thermal opening and was then involved into 1,3-dipolar cycloaddition reactions.Different five-membered adducts were obtained and were fully identified. The latter might be considered useful starting materials for further functionalization to provide novel compounds of biological interest.

NMR Investigation of the complexation of (S)-2-isopropyl- 1-(o-nitrophenyl)sulfonyl)aziridine with -cyclodextrin

“…Among three-membered heterocycles, aziridines form a group of natural and/or synthetic organic compounds that constitute a particularly versatile class of molecules as related both to their chemical reactivity and biological properties 3,4 . We focused on synthetic sulfonyl aziridines, and we found that these compounds constituted a class of high interest because of their reactivity and biological activity 5 .…”