Background: Antibiotics, as miraculous drugs, have been used extensively to confront fatal infection, even without prescriptions. However, the inappropriate and disproportionate use of antibiotics have led to the emergence of new drug-resistant bacteria1, which causes a high risk of serious diseases and dramatically aggravates the clinical complications in hospitals.
Methods: By using the peptide coupling protocol, a simple straightforward synthesis of functionalized aziridines has been developed. By means of this synthetic strategy from readily available N-phtaloyl acide and 2-methylbenzosulfonate aziridine using DCC as coupling agent, new tosylates aziridines could be obtained. The coupling reactions occurred without a ring opening of the three membered ring.
Results: This work describes new results of our ongoing research targeting new derivatives of biological interests. All the compounds were screened for their antibacterial activity; they all showed comparable moderate to good growth inhibitory activity with reference to tetracyclin and gentamicin.
Conclusion: In conclusion, we reported the synthesis and a preliminary antibacterial evaluation of novel functionalized tosylaziridines. The synthetic strategy relies on the coupling reactions between tosylaziridines and amino acids. Moreover, and besides showing interesting antibacterial activities, the series of novel compounds can be further improved to serve as potential drug against nosocomial diseases.
Background: Hospital wastewater (WWs) represents a particular type of effluent, compared with urban wastewater. Hospitals generate on average 750 L of wastewater by the bed and by day so they are 2-5 times higher than urban flow rates, which refer to one inhabitant equivalent (typically included in the interval 120-250 L). This significant quantity of water per day for different purposes and services depending on the activities which take place within the structure. Methods: In our work, we proposed two methods; the first one is the complexation with CD for the treatment of drugs from Hospital WWs, which makes solid precipitate that can be filtered later. Our second method is the photodegradation of most drugs found in Hospital WWs with a UV lamp and time for each type of drug elimination. Results: Our result for the first method is the formation of a CD-drug complex as a solid precipitate which will be filtered later and eliminate the solution to be purified. For the second method, the use of the UV lamp at 300 nm gave a degradation of 70% of the drug of the solution after 30 minutes of irradiation. The follow-up of the photodegradation was carried out by UV spectroscopy.
Conclusion:The elimination of drugs from hospital waters is essential, the method we have developed on a small scale can be standardized in Algerian hospitals that do not contain hospital water treatment policies, before reaching urban waters. This congress will be the occasion to discuss this national problem and a call of installation of ministry at the level of each hospital.
Aziridines constitute an interesting class of organic compounds because of their reactivity and the facility they can be converted into various derivatives. Our group has developed a new class of aziridines that show interesting biological activities such as antitumor and anti bacterial. This work describes new results of our ongoing research targeting new derivatives of biological interest.
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