Synthesis and simulation of new cyclodextrin derivatives breaker for Aß42

Abstract

The amyloid Ab-42, a peptide involved, following a conformational change in b sheets in the pathology of the main neurodegenerative disorder of Alzheimer's disease, is targeted in our study, the latter of which reports the synthesis of two Inhibitors linked to a specific recognition sequence synthesized during this work (Tryp-Val-Val-COOH), one linked to an aziridine and the other to a methylated β-CD in order to be able to stop the aggregation of the peptide involved.