The surge in dopamine in ventral striatal regions in response to drugs of abuse and drug-associated stimuli is a final common pathway of addiction processes. GABA B agonists exert their effects indirectly, by quieting dopaminergic afferents. The ability of the GABA B agonist, baclofen ® to ameliorate nicotine and drug motivated behaviour, particularly with respect to its possible utility as a smoking cessation agent. This article provides a review of the use of baclofen ® in the treatment for different addiction. First, we present a brief overview of treatments of addictions for various substances of abuse, including alcohol, nicotine, and cocaine. Second part, summarizes the state of knowledge about the chemistry and toxicology of cigarette smoke. The section on "Chemistry" describes the chemical components of cigarette smoke and addresses aspects of product design. Finally, we come back to discuss some problems related to properties of baclofen ® that needs to be resolved, and our current investigation, to improve the therapeutic activity of baclofen ®. We conclude by an open question to doctors (addictologists and psychiatrists) hoping an answer as soon as possible.