Untitled

Abstract

The formulation of antisense oligonucleotides within alginate and poly-L-lysine microparticles is a promising strategy for the oral application.

Effect of polysaccharide nanocrystals on structure, properties, and drug release kinetics of alginate-based microspheres

“…Because of the limited mechanical stability, durability, and high-diffusion rates resulting from the high porosity [8] (which results in low encapsulation efficiency and limited control over the kinetics of drug release) the practical applications of alginate as a drug delivery system are hindered. To improve the properties of alginate-based microspheres and to cover shortages of drug transporters, many different materials have been proposed to mix with alginate, including both synthetic [9][10][11][12] and natural polymers [13][14][15][16][17][18][19]. The attempts utilized in these studies however, could either not combine effective reinforcement of the structural strength of microspheres with biocompatibility [20], or they involved the use of organic solvent or organic crosslinking agents [21][22][23].…”

Hydrophobic modification of sodium alginate and its application in drug controlled release

“…In general, biomolecules which do not interact ionically with the alginate are rapidly released (within a few hours), and the release profiles are often characterized by a more or less pronounced burst effect. To reduce the high protein diffusion, it has been proposed to coat the alginate beads, for example, with polycationic water-soluble polymers such as poly-L-lysine [2][3][4], chitosan [5][6][7], dextrin [8], aminopoly(oxyethylene) [9] or proteins [10,11]. Covalent modification of alginates by hydrophobic materials is an effective way for the increase of drug loading and the controlled release.…”

Physical alginate hydrogels based on hydrophobic or dual hydrophobic/ionic interactions: Bead formation, structure, and stability

“…Various kinds of cross-linking reagents have been used [16][17][18]. Addition of a polycation such as poly-L-lysine [19][20][21], chitosan [22][23][24], DEAE-dextran [25], amino-polyoxyethylene [26], or proteins [27,28] to the gelation medium induces formation of complexes which stabilize the gel network and reduce its permeability.…”