Physical alginate hydrogels based on hydrophobic or dual hydrophobic/ionic interactions: Bead formation, structure, and stability

Boisseson, M. Rastello de; Léonard, Michèle; Hubert, P.; Marchal, Philippe; Stequert, A.; Castel, Christophe; Favre, Éric; Dellacherie, Édith

doi:10.1016/j.jcis.2003.12.064

Cited by 84 publications

(42 citation statements)

References 45 publications

(45 reference statements)

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“…Alginate hydrogels and microcapsules are prepared via G-blocks (e.g. calcium, strontium and barium cations) and used for drug delivery applications [229][230][231]. SPIONsalginate microcapsules were successfully employed for enhancing MRI image resolution [232,233].…”

Section: Alginatementioning

confidence: 99%

Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

Mahmoudi

Simchi

Imani

2010

JICS

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Superparamagnetic iron oxide nanoparticles (SPIONs) are promising materials for various biomedical applications including targeted drug delivery and imaging, hyperthermia, magneto-transfections, gene therapy, stem cell tracking, molecular/cellular tracking, magnetic separation technologies (e.g. rapid DNA sequencing), and detection of liver and lymph node metastases. The most recent applications for SPIONs for early detection of inflammatory, cancer, diabetes and atherosclerosis have also increased their popularity in academia. In order to increase the efficacy of SPIONs in the desired applications, especial surface coating/characteristics are required. The aim of this article is to review the surface properties of magnetic nanoparticles upon synthesis and the surface engineering by different coatings. The biological aspects, cytotoxicity, and health risks are addressed. Special emphasis is given to organic and inorganic-based coatings due to their determinant role in biocompatibility or toxicity of the final particles.

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Section: Alginatementioning

confidence: 99%

Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

Mahmoudi

Simchi

Imani

2010

JICS

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“…Knowledge on bead stability is needed since stability is directly related to its performance and limitations in many applications. The properties of calcium alginate gel have been widely studied and numerous efforts have been made to increase the bead stability [8]. However, as far as we are aware, studies on bead stability in seawater are relatively scarce.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Marine Microalgae Immobilization in Alginate Bead for Marine Water Treatment: Bead Stability, Cell Growth, and Ammonia Removal

Soo

Chen

Bojo

et al. 2017

International Journal of Polymer Science

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Sodium alginate is the most commonly used polymer matrix in microalgae immobilization for water treatment. However, the susceptibility of alginate matrixes to cation chelating agents and antigelling cation limits the use of alginates in estuarine and marine systems. Hence, the present study aims to investigate the stability of alginate bead in marine water and the feasibility of microalgae to grow when immobilized in alginate bead for marine water treatment. Different concentrations of alginate and hardening cation calcium were used to formulate beads. The beads were incubated in Guillard's f/2 medium and shaken vigorously by using orbital shaker for 15 days. The results indicated that bead stability was enhanced by increasing alginate and CaCl 2 concentrations. Subsequently, the marine microalga, Nannochloropsis sp., was immobilized in calcium alginate bead. The growth and ammoniacal-nitrogen (NH 4 + -N) uptake by immobilized cell were compared with free cell culture in f/2 medium. Specific growth rate of immobilized cell (0.063 hr −1 ) was significantly higher than free cell (0.027 hr −1 ). There was no significant difference on specific uptake rate of free cell and immobilized cell; but immobilized cell removed significantly more NH 4 + -N (82.2%) than free cell (47.3%) culture at the end of the experiment. The present study demonstrated the potential use of alginate immobilization technique in marine microalgae culture and water treatment simultaneously.

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“…[1] . [1,9,10] The gel is formed via the exchange of Na + from guluronate with divalent cations, and stacking of guluronate moieties to form an egg-box structure. [1,4] Ba 2+ forms a stronger crosslinked alginate gel than Ca 2+ .…”

Section: Physicochemical and Biological Propertiesmentioning

confidence: 99%

“…The use of modified alginate in sustained-release drug delivery system design requires additional formulation or processing efforts to circumvent fast drug release in gastric region. Hydrophobically modified alginate-C12, alginate-C18 [10,[122][123][124] The alginate-Cn conjugate is amphiphilic in nature. The alkyl chains are preferentially bound to mannuronate residues than polyguluronate sequences.…”

Section: Graft Copolymer Physicochemical and Drug Release Propertiesmentioning

confidence: 99%

Alginate graft copolymers and alginate–co-excipient physical mixture in oral drug delivery

Wong

2011

Journal of Pharmacy and Pharmacology

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Objectives Use of alginate graft copolymers in oral drug delivery reduces dosage form manufacture complexity with reference to mixing or coating processes. It is deemed to give constant or approximately steady weight ratio of alginate to covalently attached co-excipient in copolymers, thereby leading to controllable matrix processing and drug release. This review describes various grafting approaches and their outcome on oral drug release behaviour of alginate graft copolymeric matrices. It examines drug release modulation mechanism of alginate graft copolymers against that of co-excipients in non-grafted formulations. Key findings Drug release from alginate matrices can be modulated through using either co-excipients or graft copolymers via changing their swelling, erosion, hydrophobicity/ hydrophilicity, porosity and/or drug adsorption capacity. However, it is not known if the drug delivery performance of formulations prepared using alginate graft copolymers is superior to those incorporating graft-equivalent co-excipient physically in a dosage form without grafting but at the corresponding graft weight, owing to limited studies being available. Conclusions The value of alginate graft copolymers as the potential alternative to alginate-co-excipient physical mixture in oral drug delivery cannot be entirely defined by past and present research. Such an issue is complicated by the lack of green chemistry graft copolymer synthesis approach, high grafting process cost, complications and hazards, and the formed graft copolymers having unknown toxicity. Future research will need to address these matters to achieve a widespread commercialization and industrial application of alginate graft copolymers in oral drug delivery

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Physical alginate hydrogels based on hydrophobic or dual hydrophobic/ionic interactions: Bead formation, structure, and stability

Cited by 84 publications

References 45 publications

Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

Feasibility of Marine Microalgae Immobilization in Alginate Bead for Marine Water Treatment: Bead Stability, Cell Growth, and Ammonia Removal

Alginate graft copolymers and alginate–co-excipient physical mixture in oral drug delivery

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