Immunopathogenesis of chronic viral hepatitides was studied by modern immunological, molecular, genetic methods. We revealed an imbalance in the production of immunoregulatory cytokines by mononuclear leukocytes (primarily of the Th2 type). The risk of progression and chronic course of viral hepatitides in Caucasian population was associated with alleles of promoter regions -330G and -592A in the IL-2 and IL-10 genes, respectively, as well as with the T/T genotype of the polymorphic region C590T in the IL-4 gene. The C/C genotype of the IL-10 gene promoter region C592A was shown to be a factor determining resistance to long-term persistence of hepatitis B and C viruses.
The aim of the study was to ventilation function of lungs and echocardiography activities right and left ventricular, blood flow disorders in pulmonary artery in confront with clinical pictures and activities portal haemodynamics in patients with a liver cirrhosis. Established, that change structural-functional activities right and left parts of heart in a liver cirrhosis depend on to a great extent, to a weight of disease and to be accompanied raorganisation of a central haemodynamics and forming pulmonary arterial hypertension. Pulmonary arterial hypertension in close association with portal circulation of the blood and represented not rare complication of a liver cirrhosis.
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