Role of genetically determined production of immunoregulatory cytokines in immunopathogenesis of chronic viral hepatitides

Наследникова, И. О.; Коненков, В. И.; Ryazantseva, N. V.; Новицкий, В. В.; Ткаченко, С. Б.; Зима, А. П.; Avdoshina, V. V.; Белобородова, Э. И.; Белобородова, Е. В.; Dortman, V. V.

doi:10.1007/s10517-007-0220-x

Cited by 14 publications

(14 citation statements)

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“…It has also been reported that the heterozygous C/A variant in the IL-10 gene promoter region C592A is associated with a major risk of progression and chronic course of viral hepatitis in a white population 30. It is therefore likely that an alteration of the host immune system due to genetic predisposition or induced by some proteins of the virus determines the switch in the predominant activation from Th1 to Th2 cells, with a consequent imbalance in the production of immunoregulatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Relationship between circulating interleukin-10 and histological features in patients with chronic C hepatitis

Bruno

Valenti

Bertino

et al. 2011

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVES:An imbalance in cytokine production may be involved in the pathogenesis of chronic C hepatitis. The aim of the study was to investigate circulating levels of interleukin-10 (IL-10) in a selected cohort of patients affected by chronic C hepatitis.DESIGN AND SETTING:Retrospective study based on consecutive hepatitis C virus patients, affected by chronic active hepatitis, attending the general hospital of hepatology unit from June to September 2009PATIENTS AND METHODS:A total of 49 patients with chronic C hepatitis and 20 healthy control subjects similar in gender and age were examined. Circulating IL-10 was assessed by ELISA commercial kit (R and D Systems) in all investigated subjects.RESULTS:There was no significant difference in IL-10 values between controls and overall patients (P>.05). Nevertheless, among patients, subjects with more severe necroinflammation had higher values than others (P<.001). Moreover, a close relationship was found between IL-10 values and serum aspartate aminotransferase (r=0.61; P<.001).CONCLUSIONS:These findings suggest that IL-10 may be a useful additional marker to assess necroinflammation and to monitor the evolution of liver damage. They also argue for a potential pathophysiological role for IL-10 in the persistence and progression of hepatitis.

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Section: Discussionmentioning

confidence: 99%

Relationship between circulating interleukin-10 and histological features in patients with chronic C hepatitis

Bruno

Valenti

Bertino

et al. 2011

Annals of Saudi Medicine

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“…The human IL-4 gene is located on chromosome 5q31 and consists of 25 kbps [16] . So far, more than 50 allelic variant polymorphisms have been found ( http://www.ncbi.nlm.nih.gov/SNP/ ), including −590C/T (rs2243250), −33C/T (rs2070874), +3437C/G (rs2227282), and 2979G/T (rs2227284) [17] . The impact of IL-4 gene polymorphisms in the pathogenesis of HBV infection has been investigated, and numerous studies have suggested that IL-4 variants play pivotal roles in hepatitis B vaccine response and HBV infection risk [18] – [21] .…”

Section: Introductionmentioning

confidence: 99%

Role of IL-4 Gene Polymorphisms in HBV-Related Hepatocellular Carcinoma in a Chinese Population

Peng

et al. 2014

PLoS ONE

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BackgroundInterleukin-4 (IL-4) is best known as an important mediator and modulator of immune and inflammatory responses. Hepatocellular carcinoma (HCC) is a typical inflammation-related cancer, and genetic variations in the IL-4 gene may be associated with the risk of hepatitis B virus (HBV)-related HCC. However, few studies have been conducted on their association.ObjectivesTo clarify the effects of IL-4 gene polymorphisms on the risk of HBV-related HCC, two common variants, −590C/T (rs2243250) and −33C/T (rs2070874), and their relationship with HBV-related disease risk were investigated in a Chinese population.Methods IL-4 −590C/T and −33C/T polymorphisms were examined in 154 patients with HBV-related HCC, 62 patients with HBV-induced liver cirrhosis (LC), 129 patients with chronic hepatitis B (CHB), and 94 healthy controls, using the polymerase chain reaction-restriction fragment length polymorphism method and DNA sequencing.ResultsOverall, no significant differences were observed regarding the IL-4 −590C/T and −33C/T polymorphism genotypes, alleles, or haplotypes between the patient groups and the healthy controls. However, the CC genotypes of IL-4 −590C/T and −33C/T polymorphisms were observed to be significantly associated with CHB in subgroup analysis in males [CC versus TT (OR: 4.193, 95% CI: 1.094–16.071, P = 0.037; and OR: 3.438, 95% CI: 1.032–11.458, P = 0.044) and CC versus TT+CT (OR: 4.09, 95% CI: 1.08–15.49, P = 0.038; and OR: 3.43, 95% CI: 1.04–11.28, P = 0.042)].ConclusionsThese findings suggest that genetic variants in IL-4 −590C/T and −33C/T polymorphisms may be a risk factor for CHB in Chinese males but not for HBV-related LC or HCC.

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“…Each study presented the distribution of genotypes in both the cases and controls on independent sampling. Two studies were not consistent with the HWE and were excluded from the meta‐analysis. The included studies had been conducted on a broad range of ethnicities that included participants from Argentina, Brazil, Britain, China, Egypt, India, Italy, Japan, Pakistan, Russia, Tunisia and United States.…”

Section: Resultsmentioning

confidence: 99%

Relationship between IL‐10 gene −1082A/G and −592C/A polymorphisms and the risk of hepatitis C infection: a meta‐analysis

Sun

Shi

et al. 2013

Journal of Viral Hepatitis

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Increasing evidence suggests that interleukin-10 (IL-10) gene promoter polymorphisms may be associated with chronic hepatitis C virus (HCV) infection and HCV clearance. To more precisely estimate the association between these variants and the risk of HCV infection, we performed a meta-analysis of 26 studies describing the IL-10-1082A/G, -819C/T, -592C/A genotypes, including 4039 chronic HCV infection cases and 2902 controls. When compared with a healthy population, the -1082GG allele had a 43% increased risk of chronic HCV infection in combined populations (GG vs GA + AA: odds ratio (OR) = 1.433, 95% confidence interval (CI) = 1.052-1.952, P = 0.023). In subgroup analysis by ethnicity, a significant increased risk was associated with the -1082GG genotype in the Caucasian population (GG vs AA: OR = 1.390, 95% CI: 1.108-1.744, P = 0.004; GG vs GA + AA: OR = 1.621, 95% CI: 1.267-2.075, P = 0.000). However, no significant association was found in Asian, African or Chinese populations. Moreover, a higher distribution of -592A was found in the spontaneously recovered population (AA vs CC: OR = 0.585, 95% CI = 0.387-0.884, P = 0.011; AA + AC vs CC: OR = 0.738, 95% CI = 0.551-0.988, P = 0.041; AA vs AC + CC: OR = 0.788, 95% CI = 0.664-0.935, P = 0.006) than that in the chronic HCV infection population. In conclusion, the IL-10-1082GG allele may increase the risk of chronic HCV infection in Caucasian population, and people carrying the IL-10-592A allele are more likely to clear HCV spontaneously.

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Role of genetically determined production of immunoregulatory cytokines in immunopathogenesis of chronic viral hepatitides

Cited by 14 publications

References 5 publications

Relationship between circulating interleukin-10 and histological features in patients with chronic C hepatitis

Relationship between circulating interleukin-10 and histological features in patients with chronic C hepatitis

Role of IL-4 Gene Polymorphisms in HBV-Related Hepatocellular Carcinoma in a Chinese Population

Relationship between IL‐10 gene −1082A/G and −592C/A polymorphisms and the risk of hepatitis C infection: a meta‐analysis

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