Mechanisms of fatigue during exercise of circular orientation of various volume and intensity are analyzed from the position of functional systems theory. Peculiarities of fatigue anaerobic metabolism in high-speed sports, aerobic-anaerobic metabolism in sports disciplines connected with high speed endurance and aerobic metabolism in running the long and very long distances are considered. Sprint is dominated by anaerobic processes in working skeletal muscles and central mechanisms of fatigue. Central fatigue is ahead of peripheral fatigue of neuromuscular system. Anaerobic and aerobic oxidation processes occur when running athlete on medium distances. The effects of hypoxia, hypocapnia and accumulation of oxidation products from the working muscles begin to emerge. Disorders in respiratory and cardiovascular system appear. At long distances deep metabolic aerobic changes come, toxic products of metabolism accumulate, water-salt balance impairs, the cellular and molecular processes of excitation in the central and peripheral nervous system change. A combination of different disabilities leads to decrease the athlete neuromuscular system efficiency. System approach enables to reveal the fine line between achieving the body of a new quality level of adaptation to physical loads and breakdowns of compensatory mechanisms associated with the stress of functional systems for ensuring the work.
The authors give an explanation of individually dosed heat-cold treatments in combination with electro laser myostimulation and external contre-pulsation carried out at 70 athletes aged 28-32 years involved in cyclic sports. The results of clinical and biochemical laboratory tests, determination of adrenaline and noradrenaline by liquid chromatography, the content of vitamins and betacarotene - demonstrated normalization of auto-nomic functions, such as reducing the signs of emotional stress.
This review focuses on spinal and central mechanisms of fatigue associated with the implementation of adaptation programs. The morpho-functional correlations of the moto-neurons activity of the spinal cord, the activities of the functional systems of the human body, neurotransmitter systems, serotonergic, dopaminergic and noradrenergic systems in the mechanisms of fatigue were considered. The phases of the process of adaptation to physical loads as well as cumulative training effect were identified. The authors have identified and described the participation of the autonomic nervous system, glucocorticoids and other hormones and mediators in long-term adaptation to physical loads, in the transition from carbohydrate to fat type of energy metabolism. The stages of disadaptation and re-adaptation to physical activities (a manifestation of stress, rate adaptation, cybernetic principles of homeostasis) have been identified and described. The two-circuit system homeostasis: the autonomic (controlling) and myocardial-hemodynamic (controlled) was demonstrated and an hierarchy of control has been defined.
This brief report presents a description of the basic properties of mitochondria, providing a formation of energy in the human body, the ability to control a formation of energy under the influence of the Mexidol. The authors showed the main physiological effects of Mexidol in athletes and in various pathologies. A comparative study of growth performance of the pressing the barbell in the posture of lying and deadlifts in the main group of 15 people and control of 23 athletes was carried out. The athletes of the main group received the Mexidol in the dose of 200 mg/kg of body weight for 2,5 weeks. The authors found no significant increase of results in this group compared with the control and defined the importance of further studies of the properties of mitochondria and opportunities of the Mexidol in their modulation.
The article is devoted to studying the condition of central and autonomic nervous systems in the recovery period after the refusal of intensive physical load. The study involved 25 young men aged 18, 4 ± 0, 3 year. Each of them, it was offered a test with increasing in intensity step-dosed physical load on the cycle ergometer. "Sports Art 5005" ergometer was used for load testing and the testing itself was conducted under ECG and EEG control. A spectral analysis of ECG and analysis of heart rate variability were conducted. The heart rate, Kerdo index, stroke volume, cardiac output blood flow were calculated. The full EEG spectral power and spectral powers of separate rhythms were evaluated. Blood pressure was measured in the «background» status, at the moment of failure to take the load and after the recovery. The authors evaluated the level of self-feeling and fixed subjective complaints. It is shown, that at the time of failure of intense load subjects reach of the limit of their physical capacity level, which is reflected in the increasing of sympathetic effects. It´s marked in increase in heart rate and hemodynamic parameters. At time when the motoric program was stopped, the subjects were begun to the recovery. It was accompanied by a significant increase in spectral power of delta waves in the prefrontal and occipital cortex of the left and right hemispheres in the 1st minute of recovery. The appearance of delta waves was due to the increasing of inhibitory processes in the cerebral cortex as a result of fatigue and they have of defensive nature. The recovery process is characterized by significant reorganizations of vegetative regulation mechanisms. It was marked a sharp increase in spectral power of VLF -waves on the third minute of recovery and a reducing of heart rate variability to the 6-th minute of recovery. Thus, the recovery process after intense physical load is characterized by significant reorganizations in condition of central nervous system and autonomic nervous system.
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