In Russia, there is still high prevalence of arterial hypertension (AH) comorbid with dyslipidaemia (DL), which increase aggregation properties of the blood cells. It seems rational to implement statins for rapid correction of aggregation properties of blood cells in AH with DL patients. Aim. To reveal the possibilities for complex influence of rosuvastatin and non-drug treatment on aggregation properties of blood cells in AH with DL patients. Material and methods. Totally, 61 patient with AH 1-2 grade studied, with risk 3 and DL IIb type, middle age. Controls were 26 clinically healthy volunteers of the same age. All patients were prescribed rosuvastatin and non-medication treatment. Antihypertension therapy-enalapril 10 mg b. i.d. Clinical and laboratory parameters registration was performed at baseline, in 6, 12, 52, 104 weeks after treatment start. For statistics, we used t-criteria by Student. Results. At the background of therapy, there signs of DL vanished, with more rapid increase of antioxidant plasma activity and with faster normalization of lipid peroxidation level. Rosuvastatin with non-drug treatment normalized aggregation properties of red blood cells, platelets, neutrophils in as low as 6 weeks of treatment by achievement of the optimum of their aggregation realization. The treatment established the effect for whole follow-up. Conclusion. To minimize the risk of hyperaggregation of blood cells and to relieve the lipid disbalance in plasma of AH with DL patients, it is recommended for them to take rosuvastatin for long time and with strict following the recommendations on non-drug interventions.
A very important mechanism for maintaining homeostasis in the animal body is platelet hemostasis. The level of his activity very strongly determines the rheology of blood in the capillaries and due to this the state of metabolism in the tissues. There is reason to believe that the growth and development of piglets depends on the level of functional activity of platelets. For this reason, studies of the age-related dynamics of platelet activity in piglets at the end of early ontogenesis are of great importance. In the study, it was found that the piglets of plant nutrition showed an increase in the aggregation capacity of platelets (aggregation of their platelets was accelerated by ADP from 34.10.12 s to 27.60.12 s, with collagen from 24.70.08 s to 17.50.10 s, with thrombin from 36.50.08 s to 28.40.12 s). The main reason for this may be an intensification of the work of receptor and postreceptor mechanisms of platelets. This was characteristic of piglets during the phase of plant nutrition of early ontogenesis to the same extent with respect to strong and weak inducers of platelet aggregation. The increase in thromboxane synthesis in platelets (from 48.50.05% to 59.80.09%) was largely due to an increase in the activity of cyclooxygenase in them (from 78,40.06% to 89.80.12%) and thromboxane synthetase (from 69.20.07% to 81.50.07%) and activation of ADP secretion from them (from 46.00.13% to 56.90.15%). The increase in hemostatic activity of platelets in piglets during the phase of plant nutrition of early ontogeny should be considered an important regulator of their microcirculation and metabolism in tissues under existing conditions of existence.
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