Diagnostics  of  erythrocytes'  early  microrheological  abnormalities  in  rats  with  experimentally  developed  obesity

Завалишина, С. Ю.; Yu.A, Vatnikov; T.S, Kubatbekov; Kulikov, Evgeny Vladimirovich; A.A, Nikishov; S.G, Drukovsky; N.G, Khomenets; E.Yu, Zaykova; M.V, Aleshin; O.I, Dinchenko; T.I, Glagoleva

doi:10.15562/bmj.v7i2.740

Cited by 2 publications

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“…The ongoing scientific research is increasingly aimed at studying in detail the main stages of the implementation of aging and the processes of formation of age-related pathology with a deep consideration of the mechanisms of gerontogenesis on various models (Klebanov et al, 2019). Modern researchers attach particular importance to monitoring various parameters of blood cells (Kulikov et al, 2020) and especially the most numerous group -erythrocytes (Zavalishina et al, 2018) in different conditions of the body (Zavalishina et al, 2019) and of course in the course of aging (Vakhtin, 2009). The significance of these studies is that aging affects the state of all cells in the body, as a rule, leading to a weakening of their work, with the occurrence of dysfunctions, and sometimes pathological processes.…”

Section: Introductionmentioning

confidence: 99%

Physiological Features of Erythrocytes in the Aging Organism

Tkacheva¹,

Медведев²,

Vorobyeva³

et al. 2023

J Biochem Technol

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The progression of aging affects various blood parameters, which can weaken the viability of the body. Clarification of various aspects of this process requires additional observations, especially with the use of animals. The study was conducted on 43 healthy outbred male rats aged 24 months. Also, 32 healthy outbred male rats 3 months old, which formed the control group, were taken under observation. The examined 24-month-old rats showed standard aging phenomena. In their erythrocytes, there was an increase in lipid peroxidation caused by a weakening of the activity of their antioxidant defense. In the blood of two-year-old rats, there was a decrease in the level of erythrocyte-discocytes. This was accompanied in them by an excess content of erythrocytes in the blood, which had a changed shape to varying degrees. In rats of the older group, erythrocyte aggregation was increased, as indicated by an increase in the numberof erythrocytes that entered the aggregates in the blood and an increase in the number of most erythrocyte aggregates with a decrease in the level of free erythrocytes. For two-year-old rats, low content of erythrocytesdisconcytes in the blood and an excess number of erythrocytes with a modified shape, as well as an increase in their aggregation, are characteristics. An important reason for these changes is the weakening of the antioxidant protection of erythrocytes, leading to a pronounced activation of lipid peroxidation in them.

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Section: Introductionmentioning

confidence: 99%