This article is devoted to the most common bone tissue tumor among children -Ewing's sarcoma. The epidemiological data, most frequent afflicted zones of bones, clinical signs, diagnostics and treatment methods are analysed. The main focus is on the molecular genetic mechanisms of carcinogenesis initiation.
This lecture reviews types, causes and key points of pathogenesis of protein, amino acids and nucleic acids metabolism disorders, as well as their clinical implications.
The lecture analyzes modern data on the types, etiology, key stages of pathogenesis, manifestations and consequences of typical forms of regional blood flow and microcirculation disorders. The lecturer dwells on typical forms of regional blood flow (in medium vessels): pathological arterial hyperemia, venous hyperemia, ischemia, and stasis. The variants of ischemia associated with increased arterial inflow to tissue or organ are considered as compared to medium-normal inflow. The lecture provides data on typical hemolymph microcirculation disorders, including intravascular, transmural, extravascular disorders, as well as capillary-trophic insufficiency as a final result of one or more microcirculatory disorders. The blood sludge phenomenon is characterized as a pathology of the blood aggregate state, which is either a cause or a consequence of a microhemocirculation disorder. The lecture is recommended for students, medical residents, post-graduate students, and trainees of the system of post-graduate professional education at medical universities.
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