Dynamics of some parameters of hemostasis in transient coronary insufficiency depending on the duration of myocardial ischemia

Литвицкий, Петр Францевич; Yakunin, G. A.; Lavrova, L. A.; Pleshanov, A. V.; Smolyanitskii, A. Ya.

doi:10.1007/bf00831216

Cited by 4 publications

(4 citation statements)

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“…Leakage of only 1% potassium from cells 2-fold elevates its extracellular level [5]. Local rise in potassium concentration can provoke various CA (depending on the degree of membrane hypopolarization).…”

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confidence: 99%

Dysfunction of ionic channels in cardiomyocyte sarcolemma and cardiac arrhythmias

Мороз¹,

Липницкий²

2006

Bull Exp Biol Med

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The arrhythmic effects of Na+ and Ca2+ intracellular imbalance were examined on rats with aconitine-induced cardiac arrhythmias. Under conditions of Na(+)-dependent arrhythmogenesis, blockade of Ca(2+)-channels with verapamil aggravated cardiac rhythm disturbances. Correction of ionic imbalance by intravenous injection of calcium preparations in aconitine-induced arrhythmia promoted recovery of stable sinus rhythm and decreased animal mortality. Intracellular imbalance of Na+ and Ca2+ ions can underlie the arrhythmogenic effects of antiarrhythmic drugs.

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confidence: 99%

Dysfunction of ionic channels in cardiomyocyte sarcolemma and cardiac arrhythmias

Мороз¹,

Липницкий²

2006

Bull Exp Biol Med

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“…Blood supply to ischemized regions is maintained by two major sources: the collateral blood flow and retrograde venous perfusion with the dominant role of the former [3]. n-Tyrosol-induced drop in blood viscosity and decrease in aggregation capacity of erythrocytes can moderate the deleterious effects of rheological occlusion characteristic of ischemic damage to the myocardium.…”

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confidence: 99%

“…The preparation reduces the incidence of ventricular tachycardia and fibrillation, increases the percent of animals without ventricular arrhythmia, and moderates the severity of developing ventricular arrhythmias.One of the most important aspects of coronary reperfusion syndrome is cardiac arrhythmia, which in many cases leads to sudden death due to fatal hemodynamic disturbance [3]. There are published reports that n-tyrosol moderates arrhythmias caused by the toxic doses of epinephrine, but not by aconitine [2,4].…”

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confidence: 99%