Antiarrhythmic activity of n-tyrosol during acute myocardial ischemia and reperfusion

Chernyshova, G. A.; Mb, Plotnikov; Smol’yakova, V. I.; Golubeva, I V; Алиев, О. И.; Толстикова, Т. Г.; Krysin, A. P.; Sorokina, I. V.

doi:10.1007/s10517-007-0215-7

Cited by 14 publications

(5 citation statements)

References 3 publications

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“…Plotnikov et al reported that intra-gastric p -tyrosol treatment in male Wistar rats led to a pronounced reduction in platelet aggregation and blood viscosity in these rats [14]. Additionally, it has been shown that the intravenous administration of p -tyrosol 10 min prior to coronary occlusion in an in vivo acute myocardial ischemia model of Wistar rats significantly reduced the arrhythmic activity occurring during myocardial ischemia and reperfusion [15]. Moreover, p -tyrosol induced myocardial protection against ischemia-induced stress, thereby prompting the development of a new drug to combat ischemic heart diseases (IHD) while revealing potential therapeutic molecular targets such as FOXO3a and SIRT1 that can be modulated to precondition the heart to overcome ischemic stress and to inhibit the activity of leukocyte 5-lipoxygenase [16].…”

Section: Introductionmentioning

confidence: 99%

The Metabolism of Salidroside to Its Aglycone p-Tyrosol in Rats following the Administration of Salidroside

et al. 2014

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Salidroside is one of the major phenolic glycosides in Rhodiola, which has been reported to possess various biological activities. In the present study the in vivo deglycosylation metabolism of salidroside was investigated and its aglycone p-tyrosol but not the original salidroside was identified as the main form in rat tissues following the administration of salidroside. After the i.v. administration of salidroside at a dose of 50 mg/kg in rats, salidroside was quantified only in the liver, kidney and heart tissues. The highest level of p-tyrosol was detected in the heart, followed by the spleen, kidney, liver and lungs, in order. Salidroside was detected only in the liver, in contrast, p-tyrosol was detectable in most tissues except the brain, and the kidney tissues contained a significant amount of p-tyrosol compared to the other tissues after the i.g. administration of 100 mg/kg salidroside. The excretion behaviour revealed that the administrated salidroside mainly eliminated in the form of salidroside but not its aglycone metabolite p-tyrosol through urine. After i.v. and i.g. administration in rats, 64.00% and 23.80% of the total dose was excreted through urine in the form of salidroside, respectively. In addition, 0.19% and 2.25% of the dose was excreted in the form of p-tyrosol through urine after i.v. and i.g. administration, respectively. The faecal salidroside and p-tyrosol concentrations were 0.3% and 1.48% of the total dose after i.v. administration, respectively. After the i.g. administration of salidroside, trace salidroside and p-tyrosol were quantified in faeces within 72 h. In addition, the biliary excretion levels of salidroside after i.v. and i.g. administration were 2.86% and 0.02% of the dose, respectively. The obtained results show that salidroside was extensively metabolised to its aglycone p-tyrosol and distributed to various organs and the orginal salidroside was cleared rapidly through urine following the administration of salidroside.

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Section: Introductionmentioning

confidence: 99%

The Metabolism of Salidroside to Its Aglycone p-Tyrosol in Rats following the Administration of Salidroside

et al. 2014

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“…Tyrosol has been also effective in inhibiting leukocyte 5-lipooxygenase [6] and protecting the Caco-2 intestinal mucosa cells against the cytostatic and cytotoxic effects produced by oxidized LDL [7]. Many other activities of tyrosol were described such as its ability to inhibit ADP-induced platelet aggregation [8], to significantly reduce the arrhythmic activity that occurs during myocardial ischemia and reperfusion [9], and to possess significant neuroprotective activities against glutamate-induced neurotoxicity in primary cultures of rat cortical cells and injury induced by 5-S-cysteinyl-dopamine in vitro [10]. Hence, lipophilic derivatives of tyrosol and, in particular, esters bearing acyl chains, exhibit a better affinity with lipophilic membrane constituents.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of lipophilic tyrosyl esters derivatives and assessment of their antimicrobial and antileishmania activities

et al. 2012

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BackgroundPreparation of tyrosyl lipophilic derivatives was carried out as a response to the food, cosmetic and pharmaceutical industries' increasing demand for new lipophilic antioxidants.ResultsA large series of tyrosyl esters (TyC2 to TyC18:1) with increasing lipophilicity was synthesized in a good yield using lipase from Candida antarctica (Novozyme 435). Spectroscopic analyses of purified esters showed that the tyrosol was esterified on the primary hydroxyl group. Synthetized compounds were evaluated for either their antimicrobial activity, by both diffusion well and minimal inhibition concentration (MIC) methods, or their antileishmanial activity against Leishmania major and Leishmania infantum parasite species.Among all the tested compounds, our results showed that only TyC8, TyC10 and TyC12 exhibited antibacterial and antileishmanial activities. When MIC and IC50 values were plotted against the acyl chain length of each tyrosyl derivative, TyC10 showed a parabolic shape with a minimum value. This nonlinear dependency with the increase of the chain length indicates that biological activities are probably associated to the surfactant effectiveness of lipophilic derivatives.ConclusionThese results open up potential applications to use medium tyrosyl derivatives surfactants, antioxidants, antimicrobial and antileishmanial compounds in cosmetic, food and pharmaceutical industries.

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“…Plotnikov et al, have shown that intra-gastric n-tyrosol treatment in male Wistar rats exhibited pronounced reduction in platelet aggregation and blood viscosity in these rats (21). It was also shown that intravenous administration of n-tyrosol 10 min prior to coronary occlusion in in vivo acute myocardial ischemia model of Wistar rats, significantly reduced the arrhythmic activity that occurs during myocardial ischemia and reperfusion (22). Hydroxy-tyrosol treatment of HepG2 cells, improved the antioxidant defense system of these cells while increasing cellular integrity and stress resistance capabilities (23).…”

Section: Introductionmentioning

confidence: 99%

Akt/FOXO3a/SIRT1-Mediated Cardioprotection by n-Tyrosol against Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival and Longevity

Samuel

Thirunavukkarasu

Penumathsa

et al. 2008

J. Agric. Food Chem.

117

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Moderate consumption of wine has been associated with decreased risk of cardiovascular events. Recently we have shown that white wine is equally cardioprotective like red wine. However, unlike resveratrol (polyphenol in red wine), the white wine component, n-Tyrosol/2-(4-hydroxyphenyl) ethanol has not been explored for its cardioprotective effect and mechanism of action. Therefore, the present study was designed to evaluate the effect of tyrosol treatment (5mg/kg/day for 30 days) on myocardial ischemic stress in rat in vivo model of Myocardial Infarction (MI) and to identify key molecular targets involved in this mechanism. MI was induced by Left Anterior Descending (LAD) coronary artery ligation. We have observed reduced infarct size (% area at risk, 32.42 vs 48.03) and cardiomyocyte apoptosis (171vs 256 counts /100HPF) along with improvement in the myocardial functional parameters such as LVIDs (5.89 vs 6.58 mm), % Ejection Fraction (51.91 vs 45.09 %) and % Fractional Shortening (28.46 vs 23.52 %) as assessed by echocardiography in the tyrosol treated animals when compared to the non-treated controls. We have also observed significant, increase in the phosphorylation and activation of Akt (1.4 fold) and eNOS (3 fold), phosphorylation and inhibition of FOXO3a (2.6 fold) pro-apoptotic activity and increase in the expression of nuclear longevity protein SIRT1 (3.2 fold) in the tyrosol treated MI group as compared to the non-treated MI control. We have demonstrated for the first time that tyrosol induces myocardial protection against ischemia induced stress thereby prompting the development of a new drug to combat IHD, while also revealing potential therapeutic molecular targets such as FOXO3a and SIRT1 that can be modulated to precondition the heart to overcome an ischemic stress.

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Antiarrhythmic activity of n-tyrosol during acute myocardial ischemia and reperfusion

Cited by 14 publications

References 3 publications

The Metabolism of Salidroside to Its Aglycone p-Tyrosol in Rats following the Administration of Salidroside

The Metabolism of Salidroside to Its Aglycone p-Tyrosol in Rats following the Administration of Salidroside

Synthesis of lipophilic tyrosyl esters derivatives and assessment of their antimicrobial and antileishmania activities

Akt/FOXO3a/SIRT1-Mediated Cardioprotection by n-Tyrosol against Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival and Longevity

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