Regional blood flow and microcirculation disorders

Литвицкий, Петр Францевич

doi:10.24884/1682-6655-2020-19-1-82-92

Cited by 16 publications

(2 citation statements)

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“…An increase in the severity and duration of aggregation creates a risk of pathological development. The consequences of pathological aggregation are intravascular disorders of microcirculation (slowing down to stasis, turbulent blood flow and inclusion of arteriovenular shunts), hypoxia and acidosis in tissues and organs, and metabolic disorders in tissues with the development of various dystrophies [65].…”

Section: Discussionmentioning

confidence: 99%

Intercellular Interactions in Peripheral Venous Blood in Practically Healthy Residents of High Latitudes

Добродеева

Самодова

Balashova

et al. 2021

BioMed Research International

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The paper presents the results of studying the immunological parameters of 369 people who were practically healthy at the time of the survey, 298 women and 71 men, of which 216 people are living in the European North of the Russian Federation (173 women and 43 men) and 153 are residents of the Arctic (125 women and 28 men). The study was carried out in the morning (08:00–10:00 am). The study included the determination of the aggregation of erythrocytes, platelets, neutrophilic granulocytes, lymphocytes, hemogram study, hematological analysis, enzyme immunoassay, and flow cytometry. Statistical processing of the obtained data was carried out using the Statistica 7.0 software package (StatSoft, USA). It was found that the activity of aggregation of cells of peripheral venous blood in Arctic residents is 1.5–1.7 times higher than that in people living in more favourable climatic conditions. The frequency of registration of aggregation of erythrocytes and platelets is actually 2 times higher than the aggregation of leukocytes. Aggregation of erythrocytes is associated with an increase in the concentrations of transferrin and receptors for this transport protein. The frequency of detection of platelet aggregation is accompanied by an increase in transferrin concentrations; in cases of aggregation of nonnuclear blood cells, the content of NO2 in the blood serum is increased. Aggregation of neutrophilic granulocytes and lymphocytes is associated with an increase in the content of free adhesion molecules. Aggregation of erythrocytes and platelets is in evidence when it is necessary to trigger reactions of changes in the hemodynamics of microcirculation to increase the efficiency of oxygen and trophic supply of tissues. The adhesion of leukocytes to the endothelium determines the secretion of biologically active substances that contribute to a change in microcirculation and an increase in the migration of leukocytes into tissues for the implementation of phagocytic and cytolytic functions.

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Section: Discussionmentioning

confidence: 99%

Intercellular Interactions in Peripheral Venous Blood in Practically Healthy Residents of High Latitudes

Добродеева

Самодова

Balashova

et al. 2021

BioMed Research International

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“…Так, при повышении агрегации эритроцитов в кровеносной системе агрегаты могут закупоривать прекапиллярные сосуды, вызывая снижение притока крови в МЦ русло, и как следствие нарушение кровотока в соответствующих капиллярах. Кроме этого, усиленная агрегация эритроцитов в венулярном сегменте МЦ может приводить к замедлению тока крови, вплоть до его полной остановки, что приводят к снижению резерва микроциркуляторной продуктивности и, как следствие, к ухудшению тканевой перфузии [36,37].…”

Section: таблица 4 структура гемодинамических типов микроциркуляции у...unclassified

The state of microcirculation in pregnant women with hypertensive disorders in the third trimester of pregnancy

2023

RR. in B.

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Background: Hypertensive disorders during pregnancy remain the most significant problem of modern obstetrics, taking the main place in the structure of maternal and prenatal mortality and morbidity. The development of hypertensive disorders during gestation is associated with disturbances in the microcirculation system, the state of which is determined by the morphological and functional properties of its components. A comprehensive study of the state of microcirculation in pregnant women with arterial hypertension will expand the understanding of its role in the pathogenesis of hypertensive disorders. The aim of the study: To evaluate the state of the microcirculatory system and its regulation in pregnant women with various genesis hypertensive disorders in the third trimester of pregnancy. Materials and methods: A total of 151 women in the third trimester of pregnancy were examined at Gorodkov Research Institute of Mother and Child, Ivanovo. The study involved 101 patients with hypertensive disorders of various origins, including 21 women with moderate preeclampsia, 24 women with severe preeclampsia, 35 women with chronic hypertension and 21 women with chronic hypertension plus preeclampsia. The control group consisted of 50 women without signs of hypertensive disorders. Clinical and anamnestic characteristics of the study groups are given. We evaluate aggregation activity of erythrocytes. We studied the state of the microcirculation system and its regulation by laser Doppler flowmetry. Results: All types of hypertensive disorders in pregnant women are accompanied by an increase in the aggregation activity of erythrocytes, which is confirmed by an increase in the average aggregate size, aggregation index and a decrease in the percentage of non-aggregated erythrocytes. According to laser Doppler flowmetry, in pregnant women with hypertensive disorders, morphological and functional disorders of microvessels were revealed against the background of inhibition of active and activation of passive mechanisms of microcirculation regulation with a predominance of pathological types of microcirculation. Conclusion: Microcirculation disorders in pregnant women with hypertensive disorders are diverse and are associated with rheological changes in the blood and pathology of microvessels.

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Structural And Functional State Of Various Zones Of Skin Microcirculation In Men With Isolated Diastolic Hypertension

Korolev,

Fedorovich,

Gorshkov

et al. 2024

Russ Open Med J

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The objective of our study was to assess the structural and functional characteristics of various skin microcirculation zones in men with newly diagnosed isolated diastolic hypertension (IDH). Material and Methods — Our study sample included 275 men (aged 30 to 60 years) subjected to the comprehensive medical examination, which included blood tests, videocapillaroscopy (VCS) on the left ring finger, laser Doppler flowmetry (LDF) in the skin of the middle finger tip and forearm at rest, functional tests and photoplethysmography (PPG) on the left forefinger, determination of flow-mediated vasodilation of the brachial artery, echocardiography, ultrasound imaging of extracranial and femoral arteries, and also 24-hour ambulatory blood pressure monitoring (ABPM). According to the ABPM data, an isolated increase in diastolic blood pressure (BP) was noted in 83 subjects who formed the IDH group. The control group (CG) consisted of 90 men with normal BP. Results — VCS and LDF revealed no significant differences between the groups at the scale of capillaries and precapillary arterioles. According to PPG, IDH subjects had significantly higher values of reflection index vs. the CG (35.6% vs. 30.4%, p=0.0013) and lower values of ejection duration (310.5 ms and 319.5 ms, p=0.0159), respectively. Conclusion — The greatest contribution to peripheral vascular resistance in men with IDH most likely comes from large muscle arterioles, in which neurogenic regulation of vascular tone prevails.

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Regional blood flow and microcirculation disorders

Cited by 16 publications

References 0 publications

Intercellular Interactions in Peripheral Venous Blood in Practically Healthy Residents of High Latitudes

Intercellular Interactions in Peripheral Venous Blood in Practically Healthy Residents of High Latitudes

The state of microcirculation in pregnant women with hypertensive disorders in the third trimester of pregnancy

Structural And Functional State Of Various Zones Of Skin Microcirculation In Men With Isolated Diastolic Hypertension

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