The aim of the study was to establish the bacterial and viral associations of saliva and the immune resistance in 127 healthy people of different ages. The analysis sorted out three variants of oral fluid microbiota differing by certain combination of indigenous and facultative microflora. It was found that with age there is a significant increase in the number of adolescents with the third variant of the microbiota, characterized by a decrease in the number of indigenous microflora and increase in opportunistic microorganisms and viruses. With an increase in microecological shifts a tendency to decrease the level of lysozyme, an increase in the number of secretory IgA, accompanied by a decrease in antibody was revealed. It has been shown that bacterial and viral component of the microbiota of the oral fluid are in a dynamic relationship with each other, as well as immune resistance and can serve as an indicator of the health level and the selection criteria at the stages of clinical examination of children and adolescents, with the risk of dental disease.
Modern technification of medical practice reduces the humanistic potential of medicine and reduces the effectiveness of treatment.Aim of the project. To create the concept of training medical personnel based on the synergy of the best spiritual and moral traditions of the past and breakthrough scientific, creative, innovative and educational technologies to graduate a new generation of specialists who meet the modern requirements, able to meet the healthcare challenges and ready to become leaders in the medicine of the future.Results. The experience of implementing such an interdisciplinary scientific direction as medical anthropology was used, which explains the influence of various factors on the health and well-being of both one individual and a group of people and is based on the idea of humanization of medicine. A project of a new teaching concept “Tver Spiral” is proposed, where the main idea is the development of a multifaceted personality of a future doctor from the standpoint of medical knowledge, philosophy of medicine, bioethics, and biopolitics. This combines not only the contribution of fundamental knowledge and digitalization in selected areas of medicine, but also the study of a holistic approach in understanding the psychological causes, consequences and ways of improving the health and well-being of the patient as a whole.
Relevance. There are a lot of publications on the assessment of dental caries and fluorosis in children in the fluoride endemic areas. The studies on the analysis of the prevalence and severity of malocclusion in these children are few and contradictory. The aim of the study was to assess the prevalence and severity of malocclusion in schoolchildren in the endemic fluorosis areas.
Materials and methods.A cross-sectional dental examination was performed according to the WHO method with a calibration expert in 361 schoolchildren aged 12 and 15 years old living in the areas with highly fluoridated drinking water (1.5-4.5 ppm). The clinical forms of dental fluorosis were assessed by the WHO classification and the prevalence and severity of malocclusion were evaluated by the DAI index. The obtained information was processed using the SPSS ® Statistics 23.0 software.
Results. A high prevalence of dental fluorosis was revealed in the examined schoolchildren with the predominance of mild forms of pathology. Most of the children had malocclusion; mild malocclusion was most often diagnosed.Conclusions. The study did not reveal any differences between the occurrence and severity of fluoride induced dental lesions, malocclusion in the studied age and sex groups. The prevalence and severity of malocclusion were comparable in the samples of students without dental fluorosis and with various clinical forms of this pathology.
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