The article presents up-to-date information on the structure of C-reactive protein, its functions and role in risk stratification of cardiovascular diseases, cancer and mental disorders.
Objective. To conduct an analytical assessment of the dynamics of the state of patients with COVID-19 in the conditions of a clinical healthcare organization taking into account comorbid diseases.Materials and methods. 96 in-patients` medical records kept in the state healthcare institution “Gomel City Clinical Hospital No.3” have been retrospectively analyzed.Results. The median age for women having undergone hospital treatment for pneumonia associated with COVID-19 was 58 years [45; 66], for men — 58 years [39; 64]. All the patients underwent a clinical examination according to temporary protocols. The most frequent comorbid diseases in the patients with COVID-19 were: arterial hypertension, ischemic heart disease, non-alcoholic liver disease, diabetes mellitus, chronic pyelonephritis, obesity. Polymorbidity was revealed in 49 % of the patients. Most patients had moderately severe pneumonia associated with COVID-19 (75 % of all the surveyed patients). In the patients with a mild course of pneumonia associated with COVID-19, the neutrophil-to-lymphocyte ratioin the peripheral blood was 2.1, whereas in the patients with a severe course — 8.82, which correlated with traditional prognostic indicators — the levels of C-reactive protein, d-dimers, lactate dehydrogenase.Conclusion. The neutrophil-to-lymphocyte ratio in the peripheral blood is a simple and affordable method of COVID-19 course prediction in comorbid patients.
The COVID-19 infection pandemic is characterized by high morbidity, unclear prognosis of complications and a decrease in the quality of life of patients. The article presents the results of a prospective single-center cohort study of the quality of life of 134 patients who suffered from COVID-19 infection in mild and moderate forms. 99 patients reported the presence of any disorders at the time of the survey, 35 patients reported the absence of problems. 53,7% of respondents were concerned about moderate pain and/or discomfort, 41,8% of patients experienced a feeling of anxiety and/or depression and moderate mobility disorders. The median for EQ-VAS in patients with no symptoms was significantly higher compared to the median for EQ-VAS in patients with any problems (80 points versus 65 points, respectively). After a COVID-19 infection, mild to moderate forms of pain and/or discomfort, anxiety and/or depression, impaired mobility are present in half of the subjects, which leads to a decrease in the quality of life of patients.
The article presents a case of a successful application of mesenchymal stem cells in clinical practice and provides an analysis of literature sources on this topic, clinical data, and results of laboratory studies.
Objective. To perform an analytical assessment of the dynamics of COVID-19 patients` state in the conditions of a hospital healthcare organization taking into account their comorbid diseases in May 2020 and May 2021, and to determine the prognostic indicators for a severe course of COVID-19.Materials and methods. 96 medical records of COVID-19 patients who had undergone treatment at Gomel City Clinical Hospital No. 3 in May 2020 and 130 medical records of COVID-19 patients who had undergone treatment in May 2021 were retrospectively analyzed.Results. The average age of women treated for pneumonia associated with COVID-19 at the hospital healthcare organization in 2020 was 58 years, in 2021 – 64.5 years, of men in 2020 – 58 years, in 2021 – 60.5 years. All patients underwent clinical examination according to temporary protocols. The most common COVID-19 comorbid background diseases in both 2020 and 2021 were coronary artery disease (CAD), arterial hypertension (AH), non-alcoholic fatty liver disease, diabetes mellitus (DM), kidney disease, and obesity. Polymorbidity in 2021 was observed 1.5 times more often than in 2020 (pFisher<0.001). C-reactive protein (CRP) and lactate dehydrogenase (LDH) levels are statistically associated with the severity of pneumonia (rS=0.33; p<0.001 and rS=0.2; p=0.03, respectively). The neutrophillymphocyte ratio (NLR) level in patients with a mild course of pneumonia associated with COVID-19 in 2020 was 1.58, in 2021 – 1.05, while in patients with a severe course in 2020 – 7.7, in 2021 – 10.63.Conclusion. CRP, LDH and NLR serve as available methods for predicting the course of COVID-19 in comorbid patients in clinical practice.
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