Assessment of the quality of life of patients who have had COVID-19 infection, in mild and moderate forms

Никифорова, О. Л.; Galinovskaya, N. V.; Воропаев, Е. В.

doi:10.58708/2074-2088.2023-1(29)-75-81

jour

2023

DOI: 10.58708/2074-2088.2023-1(29)-75-81

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Assessment of the quality of life of patients who have had COVID-19 infection, in mild and moderate forms

О. Л. Никифорова¹,

N. V. Galinovskaya²,

Е. В. Воропаев³

Abstract: The COVID-19 infection pandemic is characterized by high morbidity, unclear prognosis of complications and a decrease in the quality of life of patients. The article presents the results of a prospective single-center cohort study of the quality of life of 134 patients who suffered from COVID-19 infection in mild and moderate forms. 99 patients reported the presence of any disorders at the time of the survey, 35 patients reported the absence of problems. 53,7% of respondents were concerned about moderate pain … Show more

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2024

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Cited by 2 publications

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Broncho-obstructive syndrome and the enzymes of cellular energy metabolism after coronavirus infection

Kosyakova,

Akulenko

2024

Russian Journal of Infection and Immunity

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Broncho-obstructive syndrome (BOS) after coronavirus infection is characterized by long-term, dry and painful cough which is hard for treatment, significantly reducing the quality of life of the patients. The goal of the study: to investigate the specific features of clinical manifestations of BOS diagnosed for the first time in patients belonging to different age groups in post-COVID-19 period and to estimate the degree of mitochondrial dysfunction by the imbalance of the enzymes of cellular energy metabolism. Materials and methods. 298 patients with BOS (age 18–78) were observed continuously for 2 years. Standard clinical, biochemical and functional examination was carried out, Saint George`s Respiratory Questionnaire (SGRQ) was used. Mitochondrial dysfunction was determined by the ratio of levels of two enzymes, lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH), in peripheral blood lymphocytes. Statistical data processing was performed in STATISTICA 10.1 program package. Results. The duration and severity of BOS manifestations increased with age, they were the most prominent in the age group older than 60 y/o. Bronchial asthma was diagnosed for the first time in 85 patients, most of them belonging to the group 18–25 y/o. In all the patients with BOS, the SGRQ coeffitient was above 50, and comorbidity was established in 82.4% of the patients. The longest duration of BOS (49.4±3.5 days) was established in the group older than 60 y/o (n = 86). LDH/SDH ratio decreased from 6 to 4.8–5.2 a.u. in all the age groups. Such changes should be taken into account in the patients from young age groups. Conclusion. The revealed low values of LDH/SDH ratio have not been shown in the available literature earlier. These values demonstrate the development of secondary mitochondrial dysfunction in post-COVID-19 period in both younger and older age groups, particularly, in patients with more severe progression of BOS. Estimation of this parameter would allow to revealthe personified characteristics for each patients, which is important for quantifying the efficacy and duration of the required antioxidant therapy.

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Broncho-obstructive syndrome and the enzymes of cellular energy metabolism after coronavirus infection

Kosyakova,

Akulenko

2024

Russian Journal of Infection and Immunity

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Interactions of humoral immune response indicators and parameters of systemic inflammatory response in patients with post-COVID-19 syndrome

Nikiforova,

Osipkina,

Galinovskaya

et al. 2024

jour

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Objective. To assess the state of the systemic inflammatory response and humoral immune response in middle-aged patients came through COVID-19 infection in mild and moderate severity. Materials and methods. A cohort single-center study involving 83 patients came through COVID-19 infection in mild and moderate severity (women - 69.9% (58 patients), men - 30.1% (25 patients); median age 53 years [49; 56] was conducted over the period 2022-2023. All patients underwent clinical examination, evaluation of humoral response with determination of IgG and IgM antibodies to SARS-CoV-2 virus, as well as concentration of interleukins: interleukin-1β, interleukin-4, interleukin-6, interleukin-8, interleukin-10, high-sensitivity C-reactive protein, tumour necrosis factor α, transforming growth factor β1 and procalcitonin concentrations. Patients were divided into three groups: 1-3 months; 3-6 months; and 6 months to 1 year after COVID-19 infection. Results. Within a year the percentage of IgM-positive patients in all patient groups was about a quarter (25 %, 21 % and 25 % respectively). While remaining within the reference values for the whole group, procalcitonin and interleukin-10 levels in the selected cohort exceeded those of the test-negative cohort (p = 0.0053 and p = 0.0044, respectively), which we considered as persistent chronic compensated inflammation. Conclusion. A quarter of patients who came through COVID-19 infection in mild and moderate severity have persistently positive IgM levels for a year, combined with proinflammatory status according to systemic inflammatory response parameters.

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Assessment of the quality of life of patients who have had COVID-19 infection, in mild and moderate forms

Cited by 2 publications

References 16 publications

Broncho-obstructive syndrome and the enzymes of cellular energy metabolism after coronavirus infection

Broncho-obstructive syndrome and the enzymes of cellular energy metabolism after coronavirus infection

Interactions of humoral immune response indicators and parameters of systemic inflammatory response in patients with post-COVID-19 syndrome

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