Background. The International Society of Hypertension and World Hypertensive League therefore joined forces to organize a concerted global effort by expanding World Hypertension Day to May Measurement Month 2017 (MMM17). The campaign was aimed to improve hypertension awareness and blood pressure control in participants with hypertension. Russian Society of Cardiology supported initiative — blood pressure measurement was performed in 11 Russian cities.Objective. The aim of our study was to estimate Russian population awareness about blood pressure in terms of campaign MMM17.Design and methods. During May 2017 we screened 1532 participants in 11 Russian cities: St Petersburg (119 participants), Moscow (102), Belgorod (28), Bryansk (405), Kemerovo (142), Krasnoyarsk (154), Samara (67), Saratov (59), Stavropol (269), Ulyanovsk (50), Surgut (137). All subjects participated voluntarily. Inclusion criteria was age age older than 18 years old. Blood pressure (BP) was measured three times with automated and manual sphygmomanometers. Questionnaire regarding diabetes mellitus, cardiovascular diseases, smoking and alcohol intake was filled in. Respondents provided information about weight and height.Results. We examined 1532 participants aged 39,3 ± 18,7 years (from 18 to 90 years old), among them 509 (33,2 %) males and 1023 (66,8 %) females. All participants were divided into 3 groups according to the date of the last BP measurement: group 1 — BP has never been checked before (n = 188, 12,3 %), group 2 — less than one year ago (n = 630, 41,1 %), group 3 — more than one year ago (n = 714, 46,6 %).Conclusions. About half of Russian participants checked blood pressure last time more than one year ago. Insufficient awareness, low compliance to antihypertensive medication and poor blood pressure control were found in Russian population independently of gender and age in both primary and secondary prevention.

Цель. Оценить уровень супероксиддисмутазы (СОД) у больных ишемической болезнью сердца (ИБС), подвергающихся коронарному шунтированию (КШ), и определить ее значимость в развитии послеоперационной фибрилляции предсердий (ПОФП). Материал и методы. Обследовано 96 пациентов с ИБС, поступивших для проведения КШ. Больные были распределены на 2 группы: 1 группа -без ПОФП (67 пациентов, 80,6% мужчин, средний возраст 57,9±7,3 лет), 2 группа -с впервые возникшей ФП в раннем периоде КШ (29 пациентов, 86% мужчин, средний возраст 64,0±8,4 лет). Результаты. За период наблюдения ПОФП возникла в 30,2% случаев, в сред-нем на 4,9±3,8 сутки после операции. При сравнении с 1 группой уровень СОД оказался выше среди пациентов 2 группы (2589,8±1999,3 ед./г против 1572,8±1275,2 ед./г, р=0,034). При этом пациенты 2 группы были старше в среднем на 4 года (64,0±8,4 против 57,9±7,3 лет, р=0,048), имели большую длительность кардиоваскулярной патологии (86,9±76,1 мес. против 44,3±38,4 мес., р=0,002). У больных с ПОФП чаще встречался III функциональный класс (ФК) стенокардии (72,4% против 47,8%, р=0,028) и III ФК хронической сердеч-ной недостаточности (38,0% против 7,5%, р=0,006), отмечался больший раз-мер левого предсердия (ЛП) при сравнении с 1 группой (43,5±4,1 против 37,9±3,4 мм, р<0,001). После выполнения многофакторного анализа предсказательная ценность сохранилась для следующих параметров: размера ЛП более 41 мм -5,1 (95% ДИ, 2,1-9,8, р=0,0005), СОД более 2948 ед./г -4,4 (95% ДИ, 1,1-8,9, р=0,04). Заключение. Проведенное исследование продемонстрировало, что опера-ция КШ сопровождается активацией окислительного стресса, что приводит к снижению концентрации супероксиддисмутазы, вероятно, за счет ее потре-бления. Однако среди больных с ПОФП отмечается более выраженная актив-ность фермента. (72,4% vs 47,8%, р=0,028) and III functional class of congestive heart failure (38,0% vs 7,5%, р=0,006), they had larger left atrium (43,5±4,1 mm vs 37,9±3,4 mm, р<0,001).After multifactorial analysis, predictive value remained for the following: left atrium larger than 41 mm -5,1 (95% CI, 2,1-9,8, р=0,0005), SOD more than 2948 U/g -4,4 (95% CI, 1,1-8,9, р=0,04). Conclusion.The study showed that CBG operation is followed by activation of oxidation stress which is followed by the decrease of SOD concentration, probably due to its consumption. However, among patients with PSAF there is higher activity of this enzyme.

Funding Acknowledgements Type of funding sources: None. Purpose. To estimate the effect of omega-3 polyunsaturated fatty acids (PUFAs) in prevention of postoperative atrial fibrillation (POAF) in patients with coronary artery disease undergoing coronary artery bypass graft (CABG) surgery. Methods. Studied were 306 patients who underwent CABG. All the patients were divided into two groups depending on the prescription of omega-3 PUFAs in the pre- and postoperative period by randomization method: 1 group comprised 158 patients without PUFAs (82.7% men, median age 63.0 (57.0;67.0) years, 2 group - 148 patients with PUFAs (89.3% men, median age 60.0 (57.0;64.0) years). PUFAs were prescribed 2000 mg daily starting with 5 days before CABG and 1000 mg daily after CABG for 21 days. In all the patients, we studied interleukin (IL)-6, IL-8, IL-10, NT-proBNP, troponin, superoxide dismutase (SOD), malondialdehyde (MDA), glutathione and omega-3 index. Results. During the observation period POAF occurred in 29.7% patients of group 1, and in 16.9% patients of group 2 (p = 0.009). In postoperative period patients of group 1 had median IL-6 level 39.3% higher (p = 0.001) and median IL-10 level - 20.2% higher (p = 0.01) comparing with group 2. In patients of group 2 we found SOD median level 78.9% lower (р&lt;0.0001) and MDA median level 33.8% lower compared to the patients of group 1 (р=0.03). In postoperative period in group 2 the median level of docosahexaenoic acid was 55% higher (p = 0.03), and omega-3 index - 43.4% higher (h = 0.04) compared with group 1. Conclusion. We found that patients with PUFAs had less activation of inflammation and oxidative stress after CABG than patients without PUFAs. The patients with PUFAs also had increased levels of docosahexaenoic acids and omega-3 index compared to the patients without PUFAs. We also found a significant decrease of the prevalence of POAF after CABG in patients with PUFAs.

Aim. To estimate the influence of short-term omega-3 polyunsaturated fatty acids (PUFA) treatment on the development of new cases of atrial fibrillation (AF) in patients with coronary artery disease after coronary artery bypass grafting (CABG) with the detection of indicators of inflammation, oxidative stress, myocardial injury or dysfunction. Material and methods. The patients did not receive statins at the stage of out-patient treatment. Interleukin (IL)-6, IL-8, IL-10, C-reactive protein (CRP), fibrinogen, troponin, NT-proBNP, superoxide dismutase (SOD), myeloperoxidase (MPO) levels were measured on admission and 3.6±1.3 days after CABG. All the patients were divided into two groups: group 1 comprised patients who did not receive omega-3 PUFA (51 patients, 86.3% males, mean age 62.8+4.0), 2 group included patients who received PUFA (51 patients, 90.2% males, mean age 62.1±4.0 years) 5 days (mean) before CABG at an average dose 2 g per day and for 3 weeks after CABG at an average dose 1 g per day. Results. Postoperative AF more often occurred in group 1 (41.2% vs 23.5%; p=0.04 ( mean 4.8±3.0 days). The patients of group 1 more often had FC-III angina pectoris (60.8% vs 51.0%, p=0.04), whereas patients of group 2 more often had the history of myocardial infarction (78.4% vs 58.8%, p=0.03) and respiratory pathology (23.5% vs 2.0%, p=0.0009). According to univariate regression analysis, omega-3 PUFA intake was associated with a decrease of new episodes of AF at the early postoperative period (odds ratio (OR) 0.66; 95% confidence interval (CI) 0.43-0.9; p=0.04). IL-6 levels were significantly higher in pre- and postoperative periods in patients of group 1 (34.8±25.5 pg/ml vs 2.9±2.5 pg/ml, p<0.0001; 54.6±44.9 pg/ml vs 39.5±29.7 pg/ml, p=0.04, respectively). Before CABG, SOD levels in both groups were higher than normal (group 1 - 3478.6±2365.7 units/g vs group 2 - 2893.4±2365.7 units/g, p>0.05). After CABG, SOD levels became lower in both groups but remained significantly higher in group 1 (2311.8±1371.6 units/g vs 662.5±572.4 units/g, р<0.0001). MPO after CABG was insignificantly raised in group 1 (before CABG - 176.8±83.8 mg/l, after CABG - 212.5±131.8 mg/l) and lowered in patients with omega-3 PUFA intake (280.4±202.1 before and 235.3±147.6 after CABG). Conclusions. The study showed that omega-3 PUFA intake in perioperative period of CABG leads to a significant decrease in occurrence of new AF cases. The patients who received omega-3 had lower IL-6 levels as a proinflammatory factor and SOD level as a marker of oxidative stress.

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Objectives to evaluate the occurrence of the main cardiovascular risk factors in medical students. Material and methods. The MMM-18 registry included 177 students of Samara State Medical University with mean age of 21.0 years. All the students filled in a survey form anonymously, where they stated their age, gender, height and weight, smoking status (yes or no), alcohol consumption (never, once a week, regularly) and also known cardiovascular diseases (coronary heart disease, stroke) and diabetes mellitus. Results and Discussion. The study confirmed the important role of conventional cardiovascular risk factors such as smoking, high body mass index, elevated blood pressure. These findings support the necessity of periodical screening of medical students in order to timely detect and correct the above-mentioned risk factors.

Цель. Выявить взаимосвязь полиморфизмов генов интерлейкина-6 (IL6, C174G), интерлейкина-10 (IL10, C592A), супероксиддисмутазы (SOD1, G8958A) и ангиотензинпревращающего фермента (ACE, Alu Ins/Del) с послео-перационной фибрилляцией предсердий (ПОФП) при коронарном шунтирова-нии (КШ) у пациентов с ишемической болезнью сердца (ИБС). Материал и методы. Обследовано 80 пациентов с ИБС, поступивших для проведения операции КШ. Проводилось генотипирование IL6 C174G, IL10 C592A, SOD1 G8958A и ACE Alu Ins/Del. В зависимости от возникновения ПОФП больные были распределены на 2 группы: 1 группа -без ПОФП (56 пациентов, 78,6% мужчин, средний возраст 61,0±7,5 лет), 2 группа -с ПОФП (24 пациента, 83,3% мужчин, средний возраст 64,7±7,9 лет). Результаты. Анализ генетических полиморфизмов показал преобладание генотипа СG IL6 C174G (57,2%), генотипа СС IL10 C592A (62,5%), генотипа GG SOD1 G8958A (87,5%), генотипа I/d ACE Alu Ins/Del (60,8%) среди больных без аритмии. У пациентов с ПОФП наибольшая распространенность выявлена для генотипа СG IL6 C174G (54,2%), генотипа СА IL10 C592A (54,2%), генотипа GG SOD1 G8958A (79,2%), генотипа I/d ACE Alu (58,4%). При проведении много-факторного регрессионного анализа отношение шансов развития ПОФП для аллеля G IL6 C174G составило 1,5 (95% ДИ, 0,69-3,44, р=0,29), для аллеля A IL10 C592A -2,7 (95% ДИ, 1,2-6,9, р=0,04), для аллеля A SOD1 G8958A -2,1 (95% ДИ, 0,7-6,2, р=0,19), для аллеля d гена ACE Alu Ins/Del -0,9 (95% ДИ, 0,27-3,1, р=0,89). Заключение. Таким образом, наличие аллеля А гена-кандидата IL10 C592A может способствовать возникновению фибрилляции предсердий в раннем послеоперационном периоде коронарного шунтирования. CI, 0,44, р=0,29), for allele A IL10 C592A -2,7 (95% CI, 1,2-6,9, р=0,04), for allele A SOD1 G8958A -2,1 (95% CI, 0,7-6,2, р=0,19), for allele d gene ACE Alu Ins/Del -0,9 (95% CI, 0,27-3,1, р=0,89). Conclusion. therefore, presence of allele A of candidate gene IL10 C592A might force the onset of atrial fibrillation during early postsurgery period in coronary bypass.Russ J Cardiol 2016, 10 (138): 37-42 http://dx

Aim - to study the peculiarities of lipid and coagulation abnormalities in high risk patients, and also the possibilities of their correction with statin therapy. Methods. 102 patients were studied, 1 group included patients with LDL 3.0-3.9 mmol/l (n=59), who received atorvastatin 40 mg daily with titration to 80 mg daily, 2 group - patients with LDL >4.0 mmol/l (n=48), who received rosuvastatin 10 mg daily with titration to 20 mg daily. Results. In the 1 group of patients, after 24 weeks mean LDL level decreased by 43.3% (p