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This is the first study in which multiple candidate genes for cerebral LR asymmetry and schizophrenia have been analyzed by sequencing. The approach to study the genetics of schizophrenia from the perspective of an LR cerebral asymmetry disturbance deserves more attention.

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The aim of the present study was to examine the characteristics of early career psychiatrists’ (ECP) work in Russia and to assess the prevalence and severity of burnout in them. Material and methods. The Early Career Psychiatrists Council of the Russian Society of Psychiatrists conducted an anonymous online survey of ECP in Russia in July-August 2019, consisted of a structured survey and screening for professional burnout using the Maslach Burnout Inventory (MBI). The final sample consisted of 165 people. Results. A high level of burnout according to at least one of the MBI scales was revealed in 79 (78.2%) women and 39 (60.9%) men (p=0.017). Mean values of the MBI Emotional Exhaustion scale corresponded to 23.33±8.97 and 17.97±8.49 (p=0.003), the MBI Depersonalization scale — 10.46±4.81 and 9.16±4.22 (p=0.083), and the MBI Personal Accomplishment scale — 33.02±5.98 and 35.32±5.75 (p=0.026) for women and men, respectively. The following risk factors for professional burnout were identified: female sex, overlapping of several working positions, difficulties in work due to changes in documentation requirements introduced since the start of professional career. Protective factors of burnout development were: work in private clinic, satisfaction with work atmosphere, subjective estimation of quality of life as above average or as good as possible. Conclusion. Burnout was established in 71.5% of ECP in Russia, which corresponds to one of the highest burnout rates in psychiatrists according to international and national studies. Further research is needed to assess the prevalence and severity and ways to prevent burnout in psychiatrists in Russia.

HIV and syphilis have similar epidemiological characteristics which causes a high level of combined infection. Both STDs affect the central nervous system early after infection. Mental disorders occur with a high incidence in HIV-infected patients and patients with syphilis, but data on the effect of combined HIV and syphilis infection on mental disorders are found only in single articles. Objectives. The goal is to study mental disorders and their effect on the commitment to observation in the infectionist in HIV-infected patients with early syphilis. Materials and methods. A comparative study of 148 patients (65 HIV-infected patients with syphilis, 50 patients with syphilis monoinfection, 33 HIV-infected patients, seronegative for syphilis) was carried out. We used clinical, psychopathological, follow-up, psychometric, laboratory and statistical methods of investigation. Results. It was found that mental disorders occur in the majority (83%) of HIV-infected patients with syphilis with the predominance of affective (54%) and addictive (48%) disorders. In HIV-infected patients with early neurosyphilis, psychogenic reactions developed statistically significantly more often than in HIV-infected patients with early syphilis. In contrast, there were no statistically significant differences in the incidence of addictive, affective, personality disorders and mental disorders due to organic brain damage in patients with early neurosyphilis and early syphilis in the case of co-infection with HIV infection. Mental disorders due to organic brain damage had a mixed genesis (including infectious) in all cases and were associated and caused by the already existing HIV infection. HIV-infected patients with syphilis, in general, were characterized by the low commitment to observation in the infectionist which were influenced by the following factors: social maladjustment, drug abuse and criminal activity. Discussion. The frequency of detected mental disorders in the examined HIV-infected patients with syphilis (83,1%) corresponded to the literature on the incidence of mental illness in HIVinfected patients inSt. Petersburg(85,6%), but was higher than the prevalence of mental disorders in patients with syphilis (68%). Given the established influence of neurosyphilis mono-infection on the development of mental disorders due to organic brain damage, it can be concluded that the disease with early neurosyphilis is important in the development of mental disorders of organic genesis. But the weight of this factor is insufficient in case of co-infection with HIV and early neurosyphilis and can only have additional significance in the development of mental disorders and the key factor is HIV-infection action. Mental disorders (addictive disorders and cognitive impairment) adversely affect the commitment to observation in the infectionist of HIV-infected patients with syphilis, therefore timely correction of mental disorders may be one of the factors improving compliance of patients. Conclusions. The study found a minor role of early neurosyphilis (as opposed to HIV infection) on the formation of mental disorders in the case of a combination of these infections. At the same time, it was found that addictive and cognitive symptomatic complexes have a negative impact on the probability of reference to an infectious disease specialist for initiating therapy in HIV-infected patients with syphilis.

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Цель. Изучение психического, когнитивного статуса и качества жизни боль-ных, перенесших аортокоронарное шунтирование (АКШ). Материал и методы. Обследован 81 больной ИБС (80% мужчин, 20% жен-щин) в возрасте 56,3±1год, перенесший плановое АКШ. На 7-8 день после АКШ выполнялся тест с 6-минутной ходьбой (ТШХ), применялись Госпиталь-ная шкала тревоги и депрессии, шкалы тревоги и депрессии Гамильтона, тре-вожности -Спилбергера, методики оценки астении и когнитивного статуса (MMSE и МоСА). Качество жизни (КЖ) оценивалось по 10-балльной визуально-аналоговой шкале, изучались поведенческие копинг-стратегии. Результаты. Показатели ТШХ составили 415±130м, КЖ -6±0,3 балла. У 35% пациентов регистрировалось снижение уровня когнитивного функционирова-ния. У 20% больных отмечались аффективные расстройства, выявлена отри-цательная корреляция ТШХ и тревоги (r=-0,3; р<0,01), аффективных рас-стройств и КЖ (r= -0,53; p<0,05). Тревога оказалась коморбидна депрессии (r=0,91; p<0,05). Умеренная и выраженная астения регистрировались у 36% и 18% пациентов, астения ассоциировалась с аффективными (r=0,96; р<0,02) и когнитивными (r=0,97; р<0,001) расстройствами. 46% больных использо-вали неконструктивные и относительно конструктивные копинг-стратегии. Заключение. На 7-8-е сутки после операции АКШ у 35% пациентов регистри-руется снижение уровня когнитивного функционирования, не менее 20% больных демонстрируют признаки аффективных расстройств, что неблаго-приятно сказывается на качестве жизни пациентов и переносимости ими физических нагрузок. Выявленные тревога и депрессия оказались ассоцииро-ванными не только между собой, но и с астенизацией пациентов. Когнитивные нарушения и эмоциональный дискомфорт, переживаемый больными, могут оказывать дезадаптирующее воздействие, приводя пациентов к использова-нию неконструктивных моделей поведения. Выявленные особенности психи-ческого и когнитивного статуса необходимо учитывать при разработке инди-видуализированных пациент-центрированных программ реабилитации боль-ных, перенесших операцию АКШ. Российский QUALITY OF LIFE AND PSYCHO-COGNITIVE CONDITION IN PATIENTS AFTER CORONARY ARTERY BYPASS GRAFT SURGERYGoruleva M. V., Ganenko O. S., Коvaltcova R. S., Kutuzova A., Petrova N. N., Demchemnko E. A., Nedoshivin A. O.Aim. To study psychic, cognitive status and life quality of petients underwent coronary bypass grafting (CABG). Material and methods. Totally 81 patient with CHD studied (80% men, 20% women) with the age 56,3±1 y. o., underwent planned CABG. On 7-8th day after CABG the 6-minute walk test (WT) was done and the Hospital anxiety-depression score used, Hamilton anxiety-depression score, Spielberger anxiety score and other methods to assess asthenia and cognitive status (MMSE, MoCA). Life Quality (LQ) assessed with 10-points visual-analogue scale; coping behavioural strategies studied.Results. Values by WT were 415±130 m, LQ -6±0,3 points. In 35% patients there was lowering of cognitive functioning. In 20% there were affective disorders and the negative correlation of WT with anxiety (r= -0,3; p<0,0...

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