The results of the long-term observations confirmed the enhanced effectiveness of the spa and health resort-based treatment of metabolic syndrome including the therapeutic courses with the intake of cooled narzan mineral water in the combination with phytococktails. This therapeutic modality increased the duration of the favorable changes of various parameters that characterize metabolic syndrome. Specifically, they persisted during 5-6 months after the application of the standard methods, were still apparent within 6-7 months after the two-week course of the treatment with cold narzan and phytococktails, and during 8-9 months when the duration of the treatment course was extended up to 3 weeks.
BACKGROUND. Cardiovascular complications caused by vascular calcification in chronic kidney disease (CKD) are closely related to disorders of bone and mineral metabolism, the mechanisms of which require further study.THE AIM: to clarify the role of the regulatory proteins of bone metabolism of sclerostin and osteoprotegerin in the processes of vascular calcification and the development of cardiovascular complications in CKD.PATIENTS AND METHODS. 110 patients with stage 3-5D CKD (67 men) were examined. Median age is 47.0 (23.0-68.0) years. Osteoprotegerin (OPG), sclerostin, intact parathyroid hormone (IPTG), troponin I in blood serum were determined using commercial kits "Enzyme-linked Immunosorbent Assay Kit for Sclerostin" ("Cloud-Clone Corp.", USA) and commercial kits "ELISA kit" ("Biomedica" (Austria) by enzyme immunoassay (ELISA). Echocardiography with Dopplerography was performed on the device "ALOKA 4000" ("Toshiba", Japan). The left ventricular myocardial mass index (LVMI) and peak systolic blood flow velocity in the aortic arch (Vps, peak systolic velocity) were determined to quantify hemodynamic changes indirectly indicating the state of the aortic vascular wall.RESULTS. Analysis of the ratios of the calculated glomerular filtration rate (EGFR), IMLJ, Vps, OPG, and sclerostin showed that a decrease in excretory kidney function is accompanied by an increase in the concentrations of OPG and sclerostin in the blood serum. At the same time, there is an increase in IMLJ and Vps. During the correlation analysis, it was shown that the level of OPG was positively correlated with the level of sclerostin and negatively with the level of iPTG.CONCLUSION. In our study, we obtained data confirming the interactive interaction between the vascular and bone systems. Morphogenetic proteins-inhibitors of bone metabolism (sclerostin and OPG) play a significant role in the defeat of the cardiovascular system in patients with CKD, as they promotes the development of vascular calcification.
original research obstetriсs and gynecology Оригинальные исследОвания Акушерство и гинекология 32 фильтративный рост. Недостатки в метаболизме эстрогена обусловлены измененной экспрессией транскрипционных генетических факторов роста и, как следствие, резистентностью к эффекту прогестерона на ткань эндометрия [12]. Функциональный полиморфизм в гене трансформирую
The work is based examination and treatment of 65 women of the premenopausal period. Assessment of daily blood pressure was carried out by the daily monitoring of blood pressure (DMBP); the state of central hemodynamics was studied by tetrapolar transthoracic rheography, the cerebral hemodynamics was studied by transcranial dopplerography (TCDH), a comprehensive assessment of the hemostasis system -by standard laboratory methods. "Dry" carbon dioxide baths are an effective method of treatment and rehabilitation of patients with a menopausal syndrome. They improve hemostasis, central and cerebral hemodynamics.
It has been established that, under the conditions of technogenic risk, the risk of the pathology of the gestation period increases, leading to the suffering of the fetus as a result of the development of placental insufficiency, an increase in perinatal losses and infant morbidity. The article presents facts about the features of the course of the gestation period, the status of fetuses and newborns under the influence of adverse environmental factors. The condition of the fetuses was determined on the basis of cardiotocography and ultrasound. In order to assess newborns, the cytokine profile and non-specific factors of body defense were studied. The positive dynamics of indicators of the state of the prenatal fetus was achieved on the inclusion in the complex of therapy of means that promote the elimination of heavy metal salts from the mother's body.
Summary. Purpose of research. Development of a method for prevention of placental insuffi ciency (PN) in high-risk pregnancy in women of the Republic of North Ossetia-Alania (RSO-A) with the complex use of antihypoxant limontar and ozone therapy (OT).
Material and methods. Observations were made of 75 pregnant residents of RSO-A with diagnosed PN, whose average age was 32,6 ± 8,14 years. Using a simple randomization method, 3 groups were formed: in the main group (OG), patients received
prevention of PN by using OT and antihypoxant limontar; in the comparison group (GS), only limontar; in the control group (KG), pregnant women did not receive prevention of PN. All patients observed before and after PN prevention were examined for placental lactogen and estriol, ultrasound of the fetoplacental complex (FPC), Doppler examination of the uterine blood fl ow and ultrasound examination of the placenta structure, and
morphological examination of the placenta.
Results. Based on identifi ed pathogenetic mechanisms of the disorders in the system “mother — placenta — fetus” are defined by a high clinical effi cacy of combined pharmaco-ozone therapy (CT) in the prevention of PN in pregnant women at risk, which was manifested by the lack of progression of PN, whereas in GS, where patients received only pharmacotherapy with limontar, progression was noted in 31,8 % of cases, in KG, where there was no prevention, is 56 %.
Conclusion. In the present study, the positive effect of OT and antihypoxant limontar on the processes of microcirculation, metabolism, and adaptation of the body, which provides a signifi cant reduction in the frequency of pregnancy complications,
increasing the adaptive capabilities of the fetus and improving perinatal outcomes.
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